MR Diffusion Tensor Imaging and Fiber Tracking in Spinal Cord Arteriovenous Malformations: A Preliminary Study

Ozanne, A.; Krings, Timo; Facon, D.; Fillard, Pierre; Dumas, Jean-Luc; Álvarez, H.; Ducreux, D.; Lasjaunias, P.

doi:10.3174/ajnr.a0541

Cited by 49 publications

(27 citation statements)

References 30 publications

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“…In previous studies, FA also correlated with clinical measures in spondylotic myelopathy (Budzik, Balbi et al 2011) and FA but not ADC metrics were correlated with motor function in SCI subjects (Chang, Jung et al 2010). In patients with poor clinical scores, FA metrics are decreased in cases of spinal cord arteriovenous but the ADC values are variable (Ozanne, Krings et al 2007). FA also correlates with disability scales in neuromyelitis optica (Qian, Chan et al 2011).…”

Section: Journal Of Neurotraumamentioning

confidence: 94%

Chronic Cervical Spinal Cord Injury: DTI Correlates with Clinical and Electrophysiological Measures

Petersen

Wilm

Meyenburg

et al. 2012

Journal of Neurotrauma

118

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Diffusion tensor imaging (DTI) is rarely applied in spinal cord injury (SCI). The aim of this study was to correlate diffusion properties after SCI with electrophysiological and neurological measures. Nineteen traumatic cervical SCI subjects and 28 age-matched healthy subjects participated in this study. DTI data of the spinal cord were acquired with a Philips Achieva 3 T MR scanner using an outer volume suppressed, reduced field of view (FOV) acquisition with oblique slice excitation and a single-shot EPI readout. Neurological and electrophysiological measures, American Spinal Injury Association (ASIA) impairment scale scores, and motor (MEP) and somatosensory evoked potentials (SSEP) were assessed in SCI subjects. Fractional anisotropy (FA) values were decreased in the SCI subjects compared to the healthy subjects. In upper cervical segments, the decrease in FA was significant for the evaluation of the entire cross-sectional area of the spinal cord, and for corticospinal and sensory tracts. A decreasing trend was also found at the thoracic level for the corticospinal tracts. The decrease of DTI values correlated with the clinical completeness of SCI, and with SSEP amplitudes. The reduced DTI values seen in the SCI subjects are likely due to demyelination and axonal degeneration of spinal tracts, which are related to clinical and electrophysiological measures. A reduction in DTI values in regions remote from the injury site suggests their involvement with wallerian axonal degeneration. DTI can be used for the quantitative evaluation of the extent of spinal cord damage, and eventually to monitor the effects of future regeneration-inducing treatments. This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof. This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof. Abstract

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Section: Journal Of Neurotraumamentioning

confidence: 94%

Chronic Cervical Spinal Cord Injury: DTI Correlates with Clinical and Electrophysiological Measures

Petersen

Wilm

Meyenburg

et al. 2012

Journal of Neurotrauma

118

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“…Space-occupying effects and a "steal phenomenon" have also been attributed to the pathogenesis and in some cases it is difficult to evaluate the exact pathomechanism [35]. If the AVM does not present initially with an acute hemorrhage, symptomatology is unspecific.…”

Section: Spinal Cord Arteriovenous Malformationsmentioning

confidence: 99%

Vascular Malformations of the Spine and Spinal Cord*

Krings

2010

Clin Neuroradiol

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Spinal vascular malformations are rare diseases with a wide variety of neurologic presentations. Their classification depends on the differentiation of shunting versus nonshunting lesions, the latter being the spinal cord cavernomas. In the shunting lesions, the next step in the proposed classification scheme is related to the feeding artery which can subdivide the dural vascular shunts from the pial vascular malformations: while those shunts that are fed by radiculomeningeal arteries (i.e., the counterparts of meningeal arteries in the brain) constitute the dural arteriovenous fistulas, the shunts that are fed by arteries that would normally supply the spinal cord (i.e., the radiculomedullary and radiculopial arteries) are the pial cord arteriovenous malformations (AVMs; whose cranial counterparts are the brain AVMs). Depending on the type of transition between artery and vein, the latter pial AVMs can be further subdivided into glomerular (plexiform or nidus-type) AVMs with a network of intervening vessels in between the artery and vein and the fistulous pial AVMs. The last step in the classification then describes whether the type of fistula has a high or a low shunting volume which will differentiate the "macro-" from the "micro"fistulas. The proposed classification is therefore based on a stepwise analysis of the shunt including its arterial anatomy, its nidus architecture and its flow-volume evaluation. The major advantage of this approach is that it leads to a subclassification with direct implications on the choice of treatment, thereby constituting a simple and practical approach to evaluate these rare diseases.

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“…Space occupying effects and a "Steal-Phenomena" have also been attributed to the pathogenesis and in some cases it is difficult to evaluate the exact pathomechanism 23 . If the AVM does not present initially with an acute haemorrhage, symptomatology is unspecific.…”

Section: Spinal Cord Avmsmentioning

confidence: 99%

Classification of Spinal Vascular Malformations

et al. 2009

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SUMMARY -Spinal vascular malformations are rare diseases with a wide variety of neurological presentations. Their classification depends on the differentiation of shunting versus non-shunting lesions, the latter being the spinal cord cavernomas. In the shunting lesions, the next step in the proposed classification scheme is related to the feeding artery which can subdivide the dural vascular shunts from the pial vascular malformations: while those shunts that are fed by radiculomeningeal arteries (i.e. the counterparts of meningeal arteries in the brain) constitute the dural arteriovenous fistulas, the shunts that are fed by arteries that would normally supply the spinal cord (i.e. the radiculomedullary and radiculopial arteries) are the pial cord arteriovenous malformations (whose cranial counterparts are the brain AVMs). Depending on the type of transition between artery and vein the latter pial AVMs can be further subdivided into glomerular (plexiforme or nidus-type) AVMs with a network of intervening vessels inbetween the artery and vein and the fistulous pial AVMs. The last step in the classification then describes whether the type of fistula has a high or a low shunting volume which will differentiate the "Macro-" from the "Micro-"fistulae. The proposed classification is therefore based on a stepwise analysis of the shunt including its arterial anatomy, its nidus-architecture and its flow-volume evaluation. The major advantage of this approach is that it leads to a subclassification with direct implications on the choice of treatment, thereby constituting a simple and practical approach to evaluate these rare diseases.

show abstract

MR Diffusion Tensor Imaging and Fiber Tracking in Spinal Cord Arteriovenous Malformations: A Preliminary Study

Cited by 49 publications

References 30 publications

Chronic Cervical Spinal Cord Injury: DTI Correlates with Clinical and Electrophysiological Measures

Chronic Cervical Spinal Cord Injury: DTI Correlates with Clinical and Electrophysiological Measures

Vascular Malformations of the Spine and Spinal Cord*

Classification of Spinal Vascular Malformations

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