MR elastography for evaluating regeneration of tissue‐engineered cartilage in an ectopic mouse model

Khalilzad-Sharghi, Vahid; Han, Zhongji; Xu, Huihui; Othman, Shadi F.

doi:10.1002/mrm.25745

Cited by 7 publications

(2 citation statements)

References 53 publications

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“…These methods include compressive mechanical testing, atomic force microscopy, magnetic resonance elastography (MRE), and ultrasound-based methods. [3][4][5][6][7][8][9][10][11][12][13][14] Ultrasound-based methods are attractive because they can typically be applied to the tissue without destroying the culture. Strain-based ultrasound elasticity imaging has been used to investigate the stiffness of tissue engineering constructs by applying compression with the ultrasound transducer and measuring the resulting strain in the sample under investigation.…”

Section: Introductionmentioning

confidence: 99%

“…8 Additional MRE work has been done on measurement of engineered samples implanted in mice. 9,10 While the elasticity measurement methods are effective, the ultrasound-based methods discussed above need a model and knowledge of the stress distribution provided by the ARF or by a transducer compressing the sample. The MRE methods use wave propagation so the stress magnitude does not need to be known.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of material properties of soft solid thin layers with acoustic radiation force and wave propagation

Urban

Nenadic

Qiang

et al. 2015

The Journal of the Acoustical Society of America

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Evaluation of tissue engineering constructs is performed by a series of different tests. In many cases it is important to match the mechanical properties of these constructs to those of native tissues. However, many mechanical testing methods are destructive in nature which increases cost for evaluation because of the need for additional samples reserved for these assessments. A wave propagation method is proposed for characterizing the shear elasticity of thin layers bounded by a rigid substrate and fluid-loading, similar to the configuration for many tissue engineering applications. An analytic wave propagation model was derived for this configuration and compared against finite element model simulations and numerical solutions from the software package Disperse. The results from the different models found very good agreement. Experiments were performed in tissue-mimicking gelatin phantoms with thicknesses of 1 and 4 mm and found that the wave propagation method could resolve the shear modulus with very good accuracy, no more than 4.10% error. This method could be used in tissue engineering applications to monitor tissue engineering construct maturation with a nondestructive wave propagation method to evaluate the shear modulus of a material.

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