MR Finding of Extraventricular Neurocytoma

Huang, Shuran; Liu, Xiaolong; Zhu, Jun; Sun, Zhanguo; Chen, Yue‐Qin; Yu, Hao

doi:10.29271/jcpsp.2022.11.1478

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…In contrast, EVN is a tumor that can arise from any location within the parenchyma and is exclusively located outside the ventricle system [ 19 ]. EVN demonstrates a variable appearance compared to that of CN, although they are largely similar [ 7 ]. The lesion in our case was mainly located intraventricularly, with only a subtle extra-ventricular portion, which could be interpreted as the origin site of the CN.…”

Section: Discussionmentioning

confidence: 99%

Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications

Sato,

Takami,

Takayanagi

et al. 2023

Brain Tumor Pathol

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Central neurocytoma (CN) is classically defined by its intraventricular location, neuronal/neurocytic differentiation, and histological resemblance to oligodendroglioma. Extraventricular neurocytoma (EVN) shares similar histological features with CN, while it distributes any site without contact with the ventricular system. CN and EVN have distinct methylation landscapes, and EVN has a signature fusion gene, FGFR1-TACC1. These characteristics distinguish between CN and EVN. A 30-year-old female underwent craniotomy and resection of a left intraventricular tumor at our institution. The histopathology demonstrated the classical findings of CN. Adjuvant irradiation with 60 Gy followed. No recurrence has been recorded for 25 years postoperatively. RNA sequencing revealed FGFR1-TACC1 fusion and methylation profile was discrepant with CN but compatible with EVN. We experienced a case of anatomically and histologically proven CN in the lateral ventricle. However, the FGFR1-TACC1 fusion gene and methylation profiling suggested the molecular diagnosis of EVN. The representative case was an “intraventricular” neurocytoma displaying molecular features of an “extraventricular” neurocytoma. Clinicopathological and molecular definitions have collided in our case and raised questions about the current definition of CN and EVN.

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Section: Discussionmentioning

confidence: 99%

Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications

Sato,

Takami,

Takayanagi

et al. 2023

Brain Tumor Pathol

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“…When the imaging findings are atypical, more aggressive treatment should be considered in patients (20). Treatment options and prognosis vary widely between CN and other ventricular tumors (21).…”

Section: Primary Site (Tumor Location)mentioning

confidence: 99%

Clinical prognostic factors for central neurocytoma and subgroup analysis of different treatment measures: A SEER database-based retrospective analysis from 2003 to 2019

Zhang

Yu²,

Zhang³

et al. 2023

Front. Oncol.

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PurposeThe study aimed to identify clinical prognostic factors affecting overall survival (OS) in patients with central neurocytoma (CN) and to determine independent prognostic factors in the subgroups of different treatment modalities using a retrospective analysis based on the SEER database from 2003 to 2019.Materials and methodsData regarding patients with CN, including basic clinical characteristics, treatment measures, and prognosis follow-up, were extracted from the SEER database. The prognostic variables for all patients were assessed using log-rank test as well as univariate and multivariate analyses based on the Cox proportional hazards model. The same statistical methods were used for analysis in different subgroups of gross total resection (GTR), subtotal resection (STR), no surgery, radiotherapy (RT), and no RT.ResultsIn total, 413 patients were enrolled in this study. Tumor size, primary site surgery, and RT were independent prognostic factors in all patients with CN. In subgroup analyses, RT was not an independent prognostic factor in patients with GTR. However, sex and race were independent prognostic factors in patients with STR. Additionally, tumor size was an independent prognostic factor in patients who did not undergo surgery. Furthermore, sex and primary site were independent prognostic factors in patients who received RT. Size and primary site surgery were independent prognostic factors in patients without RT.ConclusionIn our study, patients with small tumors or GTR or those who did not receive RT showed a better prognosis. GTR was the preferred treatment for CN. RT was not recommended for patients after GTR. Men and African American showed certain advantages after STR surgery. Tumors with a size of >4 cm were recommended for active treatment. In the RT subgroup, patients with tumors outside the ventricle or women had a poorer prognosis than those with tumors within the ventricle or men, respectively. These findings will help clinicians and patients understand the treatment and prognosis of CN visually and intuitively.

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MR Finding of Extraventricular Neurocytoma

Abstract: Objective: To determine the MR (magnetic resonance), pathologic, and clinical findings of extraventricular neurocytoma (EVN).

Cited by 2 publications

References 3 publications

Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications

Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications

Clinical prognostic factors for central neurocytoma and subgroup analysis of different treatment measures: A SEER database-based retrospective analysis from 2003 to 2019

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