MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases

Abstract

MRgFUS is a safe, noninvasive method to deliver spatially targeted monoclonal antibody across the BBB in patients with brain tumors.

Delivering Therapeutics to Glioblastoma: Overcoming Biological Constraints

“…Controlled release systems Gliadel [11,[31][32][33] Biodegradable wafers for the combined delivery of temozolomide and carmustine [34] Biodegradable polymer implants releasing rapamycin [35] Carboxymethylcellulose biopolymer system delivering rhodamine B [36] Hydrogel based co-delivery of paclitaxel and temozolomide [37] Convection enhanced delivery Temozolomide [40] Carboplatin [41] Iron oxide nanoparticles conjugated to epidermal growth factor receptor deletion mutant III antibody (EG-FRVIIIAb)/MRI-guided [43] Nanomaterial Systems Poly(ε-caprolactone) (PCL) based nanoparticle system to deliver the natural growth modulating tripeptide GHK (glycyl-L-histidyl-L-lysine) [58] Nanobubble-based theranostic system consisting of intravenously administered iron-platinum nanoparticles loaded with doxorubicin and surface-functionalized with transferrin [60] Peptide based therapeutics Tumor targeting peptides delivering deliver the oncolytic virus VSV∆M51, in combination with gadolinium [68] Self-assembled spherical nanoparticles containing a peptide probe (Cy5.5-SAPD-99mTc) with mitochondria targeting [69] Peptide derivatives of rabies virus glycoproteins, RVG29 and RVG15-liposome, delivering anticancer chemotherapeutic docetaxel nanoparticles and paclitaxel-cholesterol [70,71] WSW (also called PhrCACET1) peptide fused to paclitaxel nanosuspensions [72] Use of polydopamine (PDA)-coated zein-curcumin nanoparticles functionalized with the peptide G23 [73] Dual peptide nanocomplex created by combining SynB3 (a cell penetration peptide) with PVGLIG (an MMP-2 sensitive peptide) and paclitaxel [77] Focused ultrasound Temozolomide [84] BCNU [85] Liposomal O6-(4-bromothenyl)guanine (O6BTG) [86] Liposome-encapsulated doxorubicin [88] Cisplatin conjugated gold nanoparticles [89] Trastzumab [90] Author…”

“…MRI guided FUS (MRgFUS) was used to achieve a higher tissue delivery of liposome-encapsulated doxorubicin in rats, temozolomide in mice, and cisplatin-conjugated gold nanoparticles in mice [84,88,89]. In an additional study, MRgFUS was used to deliver the intravenously administered monoclonal antibody, trastzumab, to Her2-positive intracranial metastases in breast cancer patients without any adverse events [90].…”

A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery

“…In particular, MRgFUS may be utilized to stimulate specific brain regions and pathways in order to investigate its potential application in targeted rehabilitation. Moreover, MRgFUS is also being used as a tool to open the blood–brain barrier transiently, and this may hold promise in improving adjunct therapy such as drug delivery to glioma patients [ 54 , 55 ].…”

Triple-combination therapy assisted with ultrasound-active gold nanoparticles and ultrasound therapy against 3D cisplatin-resistant ovarian cancer model

“…It also has advantages over other clinical treatments used in cancer therapy such as photothermal therapy [9] and radiation therapy [10] since it is non-invasive, has high tissue penetration, and the acoustic wave does not cause systemic toxicity [11] . In addition to these advantages of US therapy, it offers a definite innovative and important new perspectives in cancer treatment such as an increased therapeutic concentration in the tumor [12] , immunomodulating effects [13] , and different focused ultrasound therapy modalities [14] , [15] . The combination therapy of US and chemotherapy increases the drug accumulation in the tumor cells.…”