Triple-combination therapy assisted with ultrasound-active gold nanoparticles and ultrasound therapy against 3D cisplatin-resistant ovarian cancer model

Kip, Bilgi; Tunc, Cansu Umran; Aydın, Ömer

doi:10.1016/j.ultsonch.2021.105903

Cited by 19 publications

(13 citation statements)

References 48 publications

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“…More anecdotally, spheroids have also been exploited to develop other acoustically mediated drug delivery strategies using US-induced inertial cavitation, low-intensity US (LIUS), laser-generated focused US (LGFU), and US-induced mild hyperthermia ( Table 4 ) [ 93 , 94 , 95 , 96 ]. US-induced inertial cavitation …”

Section: Resultsmentioning

confidence: 99%

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

et al. 2023

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Tumor spheroids as well as multicellular tumor spheroids (MCTSs) are promising 3D in vitro tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of drug delivery methods. These models partly reflect the tridimensional architecture of tumors, their heterogeneity and their microenvironment, which can alter the intratumoral biodistribution, pharmacokinetics, and pharmacodynamics of drugs. The present review first focuses on current spheroid formation methods and then on in vitro investigations exploiting spheroids and MCTS for designing and validating acoustically mediated drug therapies. We discuss the limitations of the current studies and future perspectives. Various spheroid formation methods enable the easy and reproducible generation of spheroids and MCTSs. The development and assessment of acoustically mediated drug therapies have been mainly demonstrated in spheroids made up of tumor cells only. Despite the promising results obtained with these spheroids, the successful evaluation of these therapies will need to be addressed in more relevant 3D vascular MCTS models using MCTS-on-chip platforms. These MTCSs will be generated from patient-derived cancer cells and nontumor cells, such as fibroblasts, adipocytes, and immune cells.

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Section: Resultsmentioning

confidence: 99%

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

et al. 2023

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“…Nanocarrier technology is often used to reduce drug doses and minimize the systemic side effects of chemotherapeutic drugs. In recent years, nanocarrier technology for delivering cisplatin has been found to enhance chemotherapy sensitivity and considerably reduce the side effects of cisplatin [7,10,[35][36][37]. Therefore, future studies are required to investigate whether TA can be used as a nanocarrier for cisplatin to determine whether this delivery method can enhance the DNA destruction ability of cisplatin more than the combination of TA and cisplatin by standard intraperitoneal injections.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical research has gradually shifted from monotherapy to combination therapy to achieve synergetic effects [9,10]. CDDP combination therapy has gained increasing attention, aiming to reduce the side effects of CDDP monotherapy [11,12].…”

Section: Introductionmentioning

confidence: 99%

Synergistic anticancer activity of cisplatin combined with tannic acid enhances apoptosis in lung cancer through the PERK-ATF4 pathway

Zheng

Yang²,

Zhai

et al. 2022

Preprint

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Background: Cisplatin (CDDP) is a common anticancer drug whose side effects limit its clinical applications. Tannins (TA) are plant-derived polyphenols that inhibit tumor growth in different types of cancer. Here, we evaluated the anticancer effect of TA combined with CDDP on lung cancer cell lines (GLC-82 and H1299) and investigated the underlying molecular mechanism of endoplasmic reticulum (ER) stress-induced apoptosis. Methods: Cell lines were treated with CDDP, TA, and CDDP+TA, and the effect of the combination was assessed using MTT assay and observed under light and fluorescence microscopes. Cell apoptosis was detected by flow cytometry, and the expression of key factors in the ER stress apoptotic pathway was detected using qRT-PCR and western blotting. The effects of the drug combination on the tumors of nude mice injected with H1299 cells were investigated, and the expression of key factors in the ER stress apoptotic pathway was investigated. Results: The combination of CDDP and TA significantly inhibited lung cancer cell viability indicating a synergistic antitumoral effect. The mRNA and protein expression levels of key ER stress factors in the CDDP+TA group were considerably higher than those in the CDDP and TA groups, the tumor volume in tumor-bearing mice was the smallest and the number of apoptotic cells and the protein expression levels of the key ER stress in the combination group were considerably higher. Conclusions: The combination of TA and CDDP may produce synergistic antitumoral effects, mediated by the PERK-ATF4-CHOP apoptotic axis, suggesting a novel adjuvant treatment for lung cancer.

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“…Au : Au nanoparticles consist of small Au particles forming nanoparticles in the shape of nanospheres, nanorods (NRs), nanocones, and nanomushrooms. 168 , 169 , 170 , 171 Au nanoparticles have a large specific surface area and optical properties that allow drugs or bioactive agents to aggregate on the surface, and are widely used in cancer therapy. 172 , 173 Due to the large specific surface area for drug delivery, multifunctional modification strategies based on Au nanoparticles can be chemically or physically conjugated.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Triple-combination therapy assisted with ultrasound-active gold nanoparticles and ultrasound therapy against 3D cisplatin-resistant ovarian cancer model

Abstract: Graphical abstract

Cited by 19 publications

References 48 publications

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

Synergistic anticancer activity of cisplatin combined with tannic acid enhances apoptosis in lung cancer through the PERK-ATF4 pathway

Multifunctional nanoparticle for cancer therapy

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