MR Hydrometry to Assess Exocrine Function of the Pancreas: Initial Results of Noninvasive Quantification of Secretion

Heverhagen, Johannes T.; Müller, Daniela; Battmann, Anke; Ishaque, Natascha; Boehm, Dominik; Katschinski, Martin; Wagner, Hans‐Joachim; Klose, K. J.

doi:10.1148/radiology.218.1.r01ja2061

Cited by 59 publications

(31 citation statements)

References 13 publications

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“…On their turn, gastric juices are utilized in the formation of the images at the MRI. There are studies demonstrating a linear relationship between the signal intensity measured by MRI and local concentration of hydrogen (18,19) . Probably, there was a difference in the concentration of such ions in the gastric juice as the patients underwent the scans after fasting and after ranitidine intake.…”

Section: Discussionmentioning

confidence: 99%

Papel da ranitidina como meio de aprimorar a qualidade do exame de colangiopancreatografia por ressonância magnética

et al. 2013

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Objective: To assess the impact of oral ranitidine on the imaging quality in magnetic resonance cholangiopancreatography (MRCP). Materials and Methods: Thirty-two patients underwent MRCP with 3D and 2D acquisitions, and three strategies for suppression of the gastrointestinal fluid signal: a) only at fasting; b) 12 hours after ingestion of 300 mg ranitidine; c) after oral administration of gadolinium solution. Three observers reviewed the images with a focus on the degree of visualization of the biliopancreatic tree. The interobserver agreement was evaluated with the kappa test. The difference between techniques and acquisition modalities were evaluated by means of average grading scores. Results: The three strategies for suppression of the gastrointestinal fluid signal presented high reproducibility. The results with suppression of the gastrointestinal fluid signal with ranitidine where similar to those obtained with fasting, and both were worse than those obtained with gadolinium solution. The 3D acquisitions surpassed 2D only in terms of visibility of the cystic duct and gallbladder, and were inferior or equivalent in the other biliopancreatic ductal segments. Conclusion: The use of ranitidine does not seem justified in the evaluation of the biliopancreatic tree at MRCP, since 2D MRCP with fasting allows the visualization of ductal structures with high quality and reproducibility in the majority of cases. Keywords: Ranitidine; Diagnostic use; Magnetic resonance cholangiopancreatography; Contrast media; Bile ducts; Pancreatic ducts.Objetivo: Avaliar o impacto da ranitidina por via oral na qualidade do exame de colangiopancreatografia por ressonân-cia magnética (CPRM). Materiais e Métodos: Trinta e dois pacientes realizaram CPRM com aquisições 3D e 2D, com três estratégias de supressão do sinal líquido gastrintestinal: a) apenas em jejum; b) 12 horas após ingerir 300 mg de ranitidina; c) após a ingestão de solução de gadolínio. Três observadores avaliaram os estudos, atentos para o grau de visualização da árvore biliopancreática. Foi medida a concordância interobservador com o teste kappa. A diferença entre técnicas e formas de aquisição foi avaliada pela média da soma dos escores de graduação. Resultados: As três estratégias de supressão do sinal líquido gastrintestinal apresentaram elevada reprodutibilidade. A supressão do sinal líquido gastrintestinal com a ranitidina foi semelhante ao jejum e ambas foram piores do que a solução de gadolínio. As aquisições 3D superaram a 2D apenas na visualização do ducto cístico e da vesícula biliar, sendo inferior ou equivalente nos demais segmentos ductais biliopancreáticos. Conclusão: O uso da ranitidina não parece justificado para aprimorar a avaliação da árvore biliopancreática em exames de CPRM. A CPRM 2D apenas em jejum permite a visualização ductal com elevada qualidade e reprodutibilidade na maioria dos casos. Unitermos: Ranitidina; Uso diagnóstico; Colangiopancreatografia por ressonância magnética; Meios de contraste; Ductos biliares; Ductos pancreáticos. Abstract...

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Section: Discussionmentioning

confidence: 99%

Papel da ranitidina como meio de aprimorar a qualidade do exame de colangiopancreatografia por ressonância magnética

et al. 2013

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“…The increase in the MR SI was related to the volume of saline solution in the calibrator, so the SI per milliliter of saline solution in the calibrator was calculated using Eq. [1]:…”

Section: Methodsmentioning

confidence: 99%

“…[1], the SI was calculated. Second, SIs of different volumes (0 -850 mL) of saline solution (0 -50 mL in 5-mL increments, 50 -100 mL in 10-mL increments, 100 -300 mL in 20 mL increments, 300 -350 mL in 10-mL increments, and 350 -850 mL in 50-mL increments) in a plastic bowl were measured.…”

Section: In Vitro Studiesmentioning

confidence: 99%

“…Moreover, the secretin test is extremely time-consuming. Recently, some researchers proposed a new method for quantification of pancreatic juice: secretin MR hydrometry (1,2). It was reported that the volume of pancreatic juice secretion significantly correlates with the maximal consistency of bicarbonate in the pancreatic juice after secretin stimulation (3,4); a decrease in the maximal consistency of bicarbonate was proposed as one of the early signs of a deficiency in the pancreatic exocrine function.…”

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confidence: 99%

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Calibrated magnetic resonance hydrometry to quantify pancreatic juice: A preliminary study

Jin

Ichikawa

Ertürk

et al. 2008

Magnetic Resonance Imaging

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Purpose:To investigate the effectiveness of the calibrated MR hydrometry (CMRH) method for accurately measuring pancreatic secretion. Materials and Methods:All studies were performed on a 1.5-T MR system using a fat-suppressed, single-shot halfFourier fast spin-echo sequence with a standard body coil. A certain volume (20 mL) of saline solution was employed as an extrabody calibrator. The validity of the CMRH method was tested both in vitro and in vivo, and actual and calculated volumes were compared. Results:The in vitro study yielded a high correlation (r ϭ 0.99; P Ͻ 0.0001) between the actual volume of saline solution in the imaging field and the calculated volume. In the in vivo study, for all volunteers, there was a very strong and significant positive correlation between the measured signal intensities or calculated volumes and actual volumes (correlation coefficient range: 0.94 -0.99; P Ͻ 0.0001).Conclusion: This preliminary study shows that CMRH is an effective tool to measure the amount of pancreatic fluid secretion.

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“…Secretin-stimulated MRCP (S-MRCP) and MR hydrometry can be useful in evaluating function, especially in the pancreatic duct (PD) [5,6]. No imaging method gives information on the slow flow found within the ducts (0-1.5 cm/s) [7,8].…”

Section: Introductionmentioning

confidence: 99%

MRI of slow flow in artificial duct in swine

et al. 2004

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Our aim was to evaluate whether it is possible to visualize slow flow within a small catheter placed inside a living animal. We used a flow-sensitive, single-shot turbo spin-echo (SS-TSE) MRI sequence, developed in house, based on diffusion-weighted (DW) techniques. Four anesthetized pigs were used as models. A plastic catheter was surgically placed within the common bile duct (CBD). To mimic flow, the catheter was filled with Ringer's acetate and connected to a pump. b factors (s/m(2)) of 0, 6, and 12, with flow velocities raging from 0 to 1.32 cm/s, were used. A total of 375 images were obtained and examined. After correction for bowel movement artifacts, all images displayed the catheter on zero flow. With a flow of 0.66 cm/s or higher, no images displayed the catheter with a b factor of 6 or 12. On the slower flow velocities, it was variable whether the catheter was visible or not, but at b=6 and flow 0.17 cm/s all catheters were viewable. This method made it possible to perform a semiquantitative evaluation of flow velocities in vivo, dividing flow into three groups.

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MR Hydrometry to Assess Exocrine Function of the Pancreas: Initial Results of Noninvasive Quantification of Secretion

Abstract: MR hydrometry is a promising noninvasive method of assessing fluid output as a measure of exocrine pancreatic function.

Cited by 59 publications

References 13 publications

Papel da ranitidina como meio de aprimorar a qualidade do exame de colangiopancreatografia por ressonância magnética

Papel da ranitidina como meio de aprimorar a qualidade do exame de colangiopancreatografia por ressonância magnética

Calibrated magnetic resonance hydrometry to quantify pancreatic juice: A preliminary study

MRI of slow flow in artificial duct in swine

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