MR Imaging Enables Real-Time Monitoring of In Vitro Electrolytic Ablation of Hepatocellular Carcinoma

Stein, Erica; Perkons, Nicholas R.; Wildenberg, Joseph C.; Iyer, Srikant Kamesh; Hunt, Stephen; Nadolski, Gregory J.; Witschey, Walter R.; Gade, T.

doi:10.1016/j.jvir.2019.07.030

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Additionally, real-time imaging will allow for more precise targeting and will thus help to keep the integrity of the surrounding structures intact. A study conducted by Stein et al [19] attempts to demonstrate the ability of magnetic resonance imaging (MRI) in visualizing the cytotoxic changes in pH that occurs in EChT between live and dead tissue in realtime. Hepatocellular carcinoma (HCC) was cultured and 6 MRI nitinol cathodes were placed in a "cage" surrounding a single central anode on the petri dish.…”

Section: The Application Of Echt To a Three-dimensional Modelmentioning

confidence: 99%

Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

O’Brien

Ignaszak

2020

ChemElectroChem

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Electrochemical therapy (EChT) is an evolving technique that allows for the minimally invasive ablation of tumors and cancers through the application of direct current (DC). The therapy boasts a low cost in comparison to many standardized procedures and could be made one of the most accessible forms of minimally invasive procedures for the targeting of tumors, owing to not only cost but also surgical simplicity. Furthermore, the treatment removes the need for oncospecific drugs and major surgical procedures, can be used when typical therapies are ill-advised, and has shown clinical success in China, Brazil, Cuba, and Germany. Here, we will explore the new technologies, mathematical models, proposed mechanisms, and applications of EChT; as these develop, EChT may soon find itself at the forefront of the oncological world.

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Section: The Application Of Echt To a Three-dimensional Modelmentioning

confidence: 99%

Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

O’Brien

Ignaszak

2020

ChemElectroChem

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“…A decreased signal is obtained in the portal phase and a relatively low signal in delayed phase, and annular pseudoenvelope enhancement can be observed. 5 HCC may present with complex signals when accompanied by bleeding or calcification, central scars, or steatosis. 6 However, the atypical features of HCC images are generally associated with pathological type, level of differentiation, and tissue composition.…”

Section: Introductionmentioning

confidence: 99%

Atypical magnetic resonance imaging features and differential diagnosis of hepatocellular carcinoma

Wang

et al. 2020

J Int Med Res

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Objective Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. We aimed to summarize and analyze the atypical magnetic resonance imaging (MRI) features of HCC to improve its diagnostic accuracy. Methods We retrospectively analyzed MRI data for 66 patients with HCC with atypical MRI features confirmed by operation and pathology. Results Twelve patients had high signals and 18 patients had significant decreases in opposed phase signals in T1WI plain scans. Nine patients had high signals and six patients had large cystic lesions in apparent diffusion coefficient images. Dynamic enhancement showed progressive enhancement in 15 patients, ring enhancement in three, irregular patchy enhancement in three, ‘nodule-in-nodule’ enhancement in six, delayed central patchy enhancement in six, delayed central ‘star-like aristate scars’ (T2WI revealed high signal intensity) in 21, and poor blood supply in three patients. Conclusions MRI can make a clear diagnosis of typical HCC, and atypical cases can also be distinguished from other tumors or tumor-like lesions by MRI. The analysis of atypical signs may improve the diagnostic accuracy of MRI for HCC.

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Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

Zhu

et al. 2022

Advanced Materials

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MR Imaging Enables Real-Time Monitoring of In Vitro Electrolytic Ablation of Hepatocellular Carcinoma

Cited by 3 publications

References 26 publications

Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

Atypical magnetic resonance imaging features and differential diagnosis of hepatocellular carcinoma

Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

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