MR Imaging Findings of a Primary Cardiac Osteosarcoma and Its Bone Metastasis with Histopathologic Correlation

Ahn, Sungyong; Choi, Jihye; Chung, Jin-Haeng; Choi, Ho-Cheol; Chun, Eun Ju; Choi, Sang Il; Kang, Heung Sik

doi:10.3348/kjr.2011.12.1.135

Cited by 12 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Primary cardiac malignancies are rare, and most cardiac tumors are metastases, which are 20 -40 fold more common than primary tumors (1,2). Benign tumors, such as myxomas, lipomas, and papillary fibroelastomas, comprise approximately 75% of all primary cardiac tumors, while primary malignant tumors comprise approximately 25%.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Primary cardiac tumors are found in 0.002% -0.3% of patients in autopsy studies (1). A primary cardiac osteosarcoma is a clinical and pathological surprise, accounting for less than 10% of primary cardiac malignancies and only 3% -9% of all cardiac sarcomas (1,2). Unlike metastatic osteosarcoma, which most often occurs in the right atrium, primary cardiac osteosarcomas arise in the left atrium (LA) in the overwhelming majority of cases (2).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Imaging Findings of a Primary Cardiac Osteosarcoma Arising From the Left Atrium and Mitral Posterior Leaflet with Multiple Metastases in A 58-Year-Old Woman

et al. 2016

View full text Add to dashboard Cite

Primary cardiac osteosarcoma is a very rare malignancy with nonspecific symptoms, making early diagnosis a challenge. We report the computed tomography and magnetic resonance imaging findings of a primary cardiac osteosarcoma arising from the left atrium and posterior mitral leaflet in a 58-year-old woman with multiple metastases to the brain, skull, clavicle, lung, ribs, liver, lymph nodes, and thyroid gland.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging Findings of a Primary Cardiac Osteosarcoma Arising From the Left Atrium and Mitral Posterior Leaflet with Multiple Metastases in A 58-Year-Old Woman

et al. 2016

View full text Add to dashboard Cite

show abstract

“…7,10) An intracardiac left atrial mass attached to the lower segment of the atrium and next PRIMARY LEFT ATRIAL OSTEOSARCOMA to the mitral valve orifice, can protrude into the left ventricle, just like in this case, rendering obstruction of blood flow and malfunction of the valve. Meanwhile, cardiac osteosarcomas are highly invasive, and frequently infiltrate into the adjacent myocardium, resulting in arrhythmia and impaired ventricular function, and to the pericardium, with pericardial effusion.…”

Section: Discussionmentioning

confidence: 99%

Primary Left Atrial Osteosarcoma

2017

View full text Add to dashboard Cite

SummaryPrimary cardiac osteosarcomas are rare entities, mostly arising from the left atrium. Because of their rarity, few reports have described this uncommon lesion. We herein report a case of primary cardiac osteosarcoma originating from the left atrium in a 34-year-old woman, who underwent tumor debulking surgery and died 3 months after being diagnosed.(Int Heart J 2017; 58: 1024-1027) Key words: Left atrium, Cardiac tumor P rimary cardiac tumors are extremely rare with a prevalence ranging from 0.001% to 0.030% in autopsy series.1) The majority of cardiac tumors are metastatic, accounting for 20-40 times more cases than primary tumors.2) Only approximately 25% of primary cardiac tumors are malignant, and less than 10% of primary cardiac malignant tumors are osteosarcoma.3,4) Primary cardiac osteosarcomas, as one subtype of sarcomas, are much rarer than other primary sarcomas, such as angiosarcoma, leiomyosarcoma, and undifferentiated sarcoma. 5)As far as it is known, there have been fewer than 40 cases reported over the last 40 years from the first case described by McConnel et al. in 1970. 6,7) Case ReportA 34-year-old woman was admitted to our department presenting with a 3-month history of progressive dyspnea and frequent expectoration. At the onset of dyspnea and expectoration episodes, she visited a regional hospital but simply received symptomatic treatment. Nevertheless, her symptoms were not alleviated. On admission, a transthoracic echocardiogram revealed a well-defined mass (57 × 32 × 28 mm) with a broad base attached to the lateral wall of the left atrium and very close to the left atrial appendage ( Figure 1A-C). Transesophageal echocardiogram detected the mass, the tip of which prolapsed into the left ventricle at the mitral valve level, causing a mild functional mitral valve stenosis ( Figure 1D). Threedimensional echocardiogram reconstructed the spatial geometric shape of the mass. It was uneven and nonlobulated, suspended from the free wall of the left atrium ( Figure 1E, F). Without further assessment of morphology, in combination with our prior experience, we diagnosed this mass as a cardiac myxoma, which in hindsight was a rushed conclusion, and therefore a surgical resection was scheduled.After induction of anesthesia, median sternotomy, cardiopulmonary bypass, and aortic and bicaval cannulation, as a set of routine procedures, were performed. Intraoperatively, the findings were beyond our expectations. The mass was not shaped like a cardiac myxoma but looked more like "fish-flesh" matter. The patient underwent a tumor debulking surgery other than complete resection due to the finding that the tumor had invaded into the ventricle, which made complete resection impossible.The tumor was detached into pieces with sharp and blunt dissection and removed from the atrium. These pieces had a smooth and irregular surface, an elastic and firm consistency, and a tannish-yellow color. Scattered hemorrhagic foci were seen in the cut sections (Supplemental Figure A).Histopathology with hematoxylin-e...

show abstract

“…(a) Gross specimen; and (b) tumour cut surfaces with solid tan-coloured appearance and focal haemorrhagic cystic change.et al7 described a patient with pericardial osteosarcoma originating in the left side of the heart posteriorly with positron emission tomography-CT correlation. The tumour was found to be heavily calcified.Most of the reported cases of primary cardiac osteosarcoma showed a predilection for the left atrium 8,9. A literature search by Takeuchi et al10 in 2007 revealed 36 cases of primary cardiac osteosarcoma worldwide.…”

mentioning

confidence: 99%