MR imaging of dedifferentiated chondrosarcoma

Eustace, S; Baker, Nancy; Lan, Howard Haw-Chang; Wadhwani, Anil R.; Dorfman, David

doi:10.1016/s0899-7071(96)00016-2

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…Radiologic features in the current case are comparable with previous studies [10,20,21]. Previous study have demonstrated that 77% of radiographs and 86% of CT scans for dedifferentiated chondrosarcomas showed intraossous calcification and that endosteal scalloping was detected in 67% of radiographs and 90% of CT scans.…”

Section: Discussionsupporting

confidence: 89%

“…In the previous studies, MR imaging have shown unique imaging features of dedifferentiated chondrosarcomas [10,20,21]. MacSweeney et al have proposed three MRI patterns in dedifferentiated chondrosarcomas: type1, two distinct signals with hyperintense chondral lesion and reduced signal intensity of dedifferentiated component; type 2, mainly reduced signal intensity with partial signal void corresponding to matrix mineralization; type 3, a heteroginous signal intensity without evidence of underlying chondral component [20]. It have been also reported that tumor bimorphism was detected 35%, 48%, and 33% of dedifferentiated chondrosarcomas in radiographs, CT scans, and MR images respectively [10].…”

Section: Discussionmentioning

confidence: 99%

“…In the current case, plain Radiographs and CT scans showed calcification in the medulla of femur and endosteal scalloping of cortex, suggesting cartilaginous tumor with invasive behavior. In the previous studies, MR imaging have shown unique imaging features of dedifferentiated chondrosarcomas [10,20,21]. MacSweeney et al have proposed three MRI patterns in dedifferentiated chondrosarcomas: type1, two distinct signals with hyperintense chondral lesion and reduced signal intensity of dedifferentiated component; type 2, mainly reduced signal intensity with partial signal void corresponding to matrix mineralization; type 3, a heteroginous signal intensity without evidence of underlying chondral component [20].…”

Section: Discussionmentioning

confidence: 99%

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Dedifferentiated Chondrosarcoma with a High-Grade Mesenchymal Component Mimicking a Gastrointestinal Stromal Tumor

Akisue¹,

Kishimoto²,

Kawamoto³

et al. 2012

OJPathology

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This report presents a dedifferentiated chondrosarcoma with a unique pathologic feature. A 63-year-old man was referred with pain and a soft tissue mass in the left groin. A plain radiograph showed a mineralization in the proximal femur with partially osteolytic foci and an abnormal shadow in the soft tissue. Magnetic resonance imaging scans showed an inhomogeneous lesion with intermediate to partially low signal intensity on T1-weighted image and intermediate to high signal intensity on T2-weighted image. Microscopically, the tumor in the femur is a low-grade chondrosarcoma and the component of soft tissue was a high-grade sarcomatous lesion with an epithelial arrangement of tumor cells. A diffuse immunoreactivity to both vimentin and c-kit (CD117) antibodies was detected in the high-grade component. A dedifferentiated component is similar to those of gastrointestinal stromal tumor (GIST). This is the first case of dedifferentiated chondrosarcoma with a high-grade component mimicking a GIST.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dedifferentiated Chondrosarcoma with a High-Grade Mesenchymal Component Mimicking a Gastrointestinal Stromal Tumor

Akisue¹,

Kishimoto²,

Kawamoto³

et al. 2012

OJPathology

View full text Add to dashboard Cite

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“…However, not commonly, radiographs may be no evidence of chondral matrix mineralization and dedifferentiation. Some authors had been reported the MRI feature of dedifferentiated chondrosarcoma, who noted that region of reduced signal intensity compared with hyper intensity chondral component was corresponded to dedifferentiation on T2 weighted spin echo or short T1 inversion recovery sequences based on small series [12–14]. Some arthors also reported that the biphasic nature (i.e., distinctly diverse tumor features juxtaposed with chondroid lesions) may be a special and typical feature for dedifferentiated chondrosarcoma [15–17].…”

Section: Introductionmentioning

confidence: 99%

Dedifferentiated chondrosarcoma: Radiological features, prognostic factors and survival statistics in 23 patients

Liu

et al. 2017

PLoS ONE

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BackgroundDedifferentiated chondrosarcoma is a rare, highly malignant tumor with a poor survival. There are many confusing issues concerning the imaging feature that can facilitate early diagnosis and the factors that might be related to outcomes.MethodsTwenty-three patients with dedifferentiated chondrosarcoma confirmed by pathology were retrospectively reviewed from 2008 to 2015. The patients’ clinical information, images from radiographs (n = 17), CT (n = 19), and MRI (n = 17), histological features, treatment and prognosis were analyzed.ResultsThere were 12 males and 11 females, and the mean age was 50.39 years old. Fourteen cases affected the axial bone (pelvis, spine), and 9 cases involved the appendicular bone. Seven (41.17%), 9 (47.36), and 12 (66.66%) lesions showed a biphasic nature on radiograph, CT and MRI, respectively. Of the lesions, 17.39% (4/23) were accompanied by pathological fractures. Histologically, the cartilage component was considered histological Grade1 in 12 patients and Grade 2 in 11 patients. The dedifferentiated component showed features of osteosarcoma in 8 cases, malignant fibrous histiocytoma in3 cases, myofibroblastic sarcoma in 1 case and spindle cell sarcoma in 11cases. Twenty-two cases were treated with surgical resection, and 17 cases achieved adequate (wide or radical) surgical margin. In 8 cases, surgery was combined with adjuvant chemotherapy. The overall median survival time was nine months; 17.4% of patients survived to five years.ConclusionAxial bone location, lung metastasis at diagnosis, inadequate surgical margin, incorrect diagnosis before surgery and pathological fractures was related to poorer outcome. Pre- or postoperative chemotherapy had no definitively effect on improved survival.

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“…Radiographs may demonstrate some features of dedifferentiation like aggressive bone destruction, cortical infiltration, a soft tissue mass with no calcification, pathologic fracture and osteoid matrix [3]. Even though some radiologic and magnetic resonance imaging features of dedifferentiated chondrosarcoma have been described [10][11][12][13], individual radiologists are still not familiar with the features of this tumor particularly in regard to its multiple malignant mesenchymal components which may have different imaging features. This study investigated the clinical, pathological and imaging features of patients with dedifferentiated chondrosarcoma confirmed by pathology so as to improve the knowledge of this disease for better diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases

Cao

Wu²,

Han

et al. 2021

BMC Musculoskelet Disord

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Background To investigate the clinical, imaging and pathological features of dedifferentiated chondrosarcoma for better diagnosis. Methods Patients who had been confirmed to have dedifferentiated chondrosarcoma were enrolled in this study and analyzed in the clinical, imaging and pathological data. Results Twenty-five patients had pathologically confirmed dedifferentiated chondrosarcoma including 15 males and 10 females with an age range of 24–74 (median 58, interquartile range 49–65). Ten patients had the tumor at the femur, four at the ilium, two at the humerus, two at the tibia, two at cotyle, and one at each of the following locations: scapula, sacrum, rib, pubic branch, and calcaneus. Twenty-one patients had local pain and a soft tissue mass while the other four patients had only local pain without a soft tissue mass. Four patients had pathological fractures. Imaging showed extensive bone destruction with calcification inside the lesion and possible pathological fractures. On gross observation of the specimen, the chondrosarcoma components were usually located inside the bone, and the dedifferentiated sarcoma components were mainly located outside the bone. Microscopy showed the dedifferentiated tumor had two components: well-differentiated chondrosarcoma and poorly differentiated non-chondral sarcoma including malignant fibrous histiocytoma in eleven cases, osteosarcoma in ten cases, fibrosarcoma in two, liomyosarcoma in one, and lipoblastoma in the remaining one.. Followed up from 3 moths to 60 months (mean 15.6), eight patients died with a survival time of 10–23 months (mean 16), and the other 17 patients survived with the survival duration from three to 60 months (15). Conclusion Dedifferentiated chondrosarcoma is a fatal disease with multiple components, and most of the cases have dual morphological and imaging features of chondrosarcoma and non-chondrosarcoma. The imaging presentations are primarily of common central chondrosarcoma, combined with cortical destruction, soft tissue mass, and pathological fractures.

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MR imaging of dedifferentiated chondrosarcoma

Cited by 9 publications

References 15 publications

Dedifferentiated Chondrosarcoma with a High-Grade Mesenchymal Component Mimicking a Gastrointestinal Stromal Tumor

Dedifferentiated Chondrosarcoma with a High-Grade Mesenchymal Component Mimicking a Gastrointestinal Stromal Tumor

Dedifferentiated chondrosarcoma: Radiological features, prognostic factors and survival statistics in 23 patients

Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases

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