MR imaging of pulmonary emboli: an experimental study in dogs

Mg, Stein; Jv, Crues; Wg, Bradley; Ke, Kortman; Ta, Andrues; Ad, Waxman; Rw, Henderson; Pj, Julien

doi:10.2214/ajr.147.6.1133

Cited by 17 publications

(2 citation statements)

References 8 publications

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“…Shortcomings of this technique include spurious results due to flow artifacts [4][5][6], spatial resolution inferior to angiography, degradation of image quality by physiologic motion, poor differentiation between thrombus and airless lung [5], and confounding signal from endobronchial mucous plugs [7]. Spin-echo MR imaging also is unable to distinguish between chronic and acute pulmonary emboli [8]; such a distinction is desirable because it could affect therapeutic decisions.…”

Section: Of the Mr Images By Two Observers In Consensusmentioning

confidence: 99%

Cine-gradient-refocused MR imaging of central pulmonary emboli

Sostman²,

Spritzer

et al. 1989

American Journal of Roentgenology

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Section: Of the Mr Images By Two Observers In Consensusmentioning

confidence: 99%

Cine-gradient-refocused MR imaging of central pulmonary emboli

Sostman²,

Spritzer

et al. 1989

American Journal of Roentgenology

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“…Keeping in mind the aim of developing a new imaging technique for early detection of pulmonary arteriopathies and/or assessment of new drugs in this field, small animal models may contribute to a significant extent. For instance it is easy to reproduce pulmonary embolism (by venous injection of gaseous blister (9) or solid clots (10–13)) or arterial pulmonary hypertension (by inoculating monocrotaline (14) or by inducing hypoxia (15)) in rats or mice.…”

mentioning

confidence: 99%

In vivo MR imaging of pulmonary arteries of normal and experimental emboli in small animals

Léderlin

Thiaudière

Laurent

et al. 2006

Magnetic Resonance Imaging

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Purpose:To demonstrate the feasibility of pulmonary MRA in living rodents. Materials and Methods:A three-dimensional (3D) gradient echo sequence was adapted to perform a time-of-flight (TOF) angiography of rat lung. Angiogram with a spatial resolution of 195 ϫ 228 ϫ 228 m 3 was acquired in around 33 minutes. The method was then applied in animals before and after pulmonary embolism (PE) induction. Section of the proximal right pulmonary artery was measured and compared between the two populations.Results: Good quality images were obtained with a contrast-to-noise ratio (CNR) of 9 Ϯ 3 in the proximal part of the pulmonary artery. Cross-section areas of the right main artery are statistically different before (3.45 Ϯ 0.69 mm 2 ) and after induction of PE (4.3 Ϯ 0.86 mm 2 ). Conclusion:This noninvasive tool permits angiogram acquisition at around 200 m spatial resolution and objective distinction between healthy and embolized arteries.

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Vascular Morphology and Function in Magnetic Resonance Imaging

Schulthess¹

1989

Morphology and Function in MRI

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MR imaging of pulmonary emboli: an experimental study in dogs

Cited by 17 publications

References 8 publications

Cine-gradient-refocused MR imaging of central pulmonary emboli

Cine-gradient-refocused MR imaging of central pulmonary emboli

In vivo MR imaging of pulmonary arteries of normal and experimental emboli in small animals

Vascular Morphology and Function in Magnetic Resonance Imaging

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