MR imaging of systemic lupus erythematosus involving the brain

We used Western blot analysis to examine the Occurrence and titer of antibody to cytoskeletal neurofilament protein antigens in patients with neuropsychiatric manifestations of systemic lupus erythematosus (SLE) and in controls. Twenty-two patients with neuropsychiatric SLE (NPSLE) had an increased incidence of antineurofilament antibody (ANFA) compared with 34 patients with SLE without neuropsychiatric symptoms, 78 patients with other disease processes, and 22 healthy controls. ANFA were found to be directed against the 205,000-and 160,000-dalton proteins of the neurofilament triplet. Patients with a diffuse NPSLE clinical presentation had the greatest frequency of serum ANFA (7 of 12,58%) compared with all other groups examined.Magnetic resonance imaging and serum anticardiolipin antibody testing were also performed in selected patients

show abstract

“…Prior studies have suggested that patients with a diffuse clinical presentation were more likely to have normal MRI findings (23,24).…”

Section: Resultsmentioning

confidence: 99%

Antineurofilament antibody evaluation in neuropsychiatric systemic lupus erythematosus

Robbins

Kornguth

Bell

et al. 1988

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Involvement of the brain is a major cause of morbidity and mortality in patients with connective tissue disease, especially in SLE and Behçet disease. The treatment is hampered by the current lack of an accurate method of diagnosis and follow-up 5 . In addition to physical examination, cerebrospinal fluid (CSF) analysis, electroencephalogram and evoked-potential studies may all be useful, but not specific 5 .…”

mentioning

confidence: 99%

“…The treatment is hampered by the current lack of an accurate method of diagnosis and follow-up 5 . In addition to physical examination, cerebrospinal fluid (CSF) analysis, electroencephalogram and evoked-potential studies may all be useful, but not specific 5 . Computerised tomography (CT) in most of the time fails in demonstrating the disease and the degree of brain involvement 6 .…”

mentioning

confidence: 99%

“…In fact, most frequently CT scans are normal or show mild cerebral atrophy. With advances in magnetic resonance imaging (MRI) techniques, the investigation became more sensitive, showing many lesions not seen on CT scans, suggestive of small vessel vasculitis, oedema, inflammatory and demyelinating lesions 5,6 . We reviewed the clinical and MRI findings of five patients with chronic aseptic meningoencephalitis associated with SLE and Behçet disease in order to access the importance of MRI in evaluating these patients.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging in the evaluation of patients with aseptic meningoencephalitis and connective tissue disorders

Appenzeller¹,

Kobayashi

Costallat

et al. 2000

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Objective: To describe the role of magnetic resonance imaging (MRI) in the evaluation of patients with chronic and recurrent aseptic meningitis.Method: A retrospective study of five patients with aseptic meningoencefalitis diagnosed by clinical and CSF findings. CT scans showed without no relevant findings. Results: MRI showed small multifocal lesions hyperintense on T2 weighted images and FLAIR, with mild or no gadolinium enhancement, mainly in periventricular and subcortical regions. Meningoencephalitis preceded the diagnosis of the underlying disease in four patients (Behçet´s disease or systemic lupus erythematosus). After the introduction of adequate treatment for the rheumatic disease, they did not present further symptoms of aseptic meningoencephalitis. Conclusion: Aseptic meningoencephalitis can be an early presentation of an autoimmune disease. It is important to emphasize the role of MRI in the diagnosis and follow-up of these patients.KEY WORDS: magnetic resonance imaging, CNS vasculitis, aseptic meningitis, systemic lupus erythematosus, lupus, Behçet disease.Ressonância magnética na avaliação de pacientes com meningoencefalite asséptica e doenças do tecido conjuntivo RESUMO -Objetivo: Investigar a importância da ressonância magnética (RM) na avaliação de pacientes com meningite asséptica crônica ou recorrente. Método: Este é um estudo retrospectivo incluindo cinco pacientes com meningite asséptica crônica ou recorrente diagnosticada com base nos dados clínicos e exame do líquido cefalorraquidiano. Os exames de tomografia computadorizada de crânio não evidenciaram achados relevantes. Resultados: A RM mostrou pequenas lesões multifocais hiperintensas em T2 e FLAIR, com pouco ou nenhum realce após injeção de gadolínio, sobretudo nas regiões periventriculares e subcorticais. O quadro de meningoencefalite precedeu o diagnóstico da doença de base (Behçet ou lupus) em quatro pacientes. Após a introdução do tratamento adequado para a doença reumatológica estes pacientes não apresentaram mais sintomas de meningoencefalite. Conclusão: Meningite asséptica pode ser uma das manifestações precoces de doença autoimune. É importante salientar o papel da RM no diagnóstico e acompanhamento desses pacientes. PALAVRAS-CHAVE: ressonância magnética, vasculite SNC, meningite asséptica, lupus eritematoso sistêmico, doença de Behçet.

show abstract

“…However, most studies consider only specific CNS manifestations in the context of separate entities, such as systemic lupus erythematosus (SLE), Sjögren's syndrome, Behçet's disease or sarcoidosis. [3][4][5][6][7][8][9][10] To the best of our knowledge, no global …”

Section: Introductionmentioning

confidence: 99%