MR volumetry of the normal fetal kidney: reference values

Michielsen, Koen; Meersschaert, Joke; Keyzer, Frederik De; Cannie, Mieke; Deprest, Jan; Claus, Filip

doi:10.1002/pd.2607

Cited by 13 publications

(8 citation statements)

References 18 publications

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“…MRI is generally considered the most reliable way to measure renal length and volume. In line with our findings, the largest study based on nuclear MRI so far, including 150 patients, did not find a significant difference in length or volume between the right and left kidneys [31]; another MRI study performed in 240 human fetuses without urogenital anomalies also did not show any difference in size between the right and left kidney [32].…”

Section: Discussionsupporting

confidence: 90%

Heritability, determinants and reference values of renal length: a family-based population study

Pruijm¹,

Ponte

Ackermann

et al. 2013

Eur Radiol

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• Renal length and volume are heritable traits, independent of age and size. • Based on a European population, gender-specific reference values/percentiles are provided for renal length. • Renal length correlates positively with body length and weight. • There was no difference between right and left renal lengths in this study. • This negates general teaching that the left kidney is larger and longer.

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Section: Discussionsupporting

confidence: 90%

Heritability, determinants and reference values of renal length: a family-based population study

Pruijm¹,

Ponte

Ackermann

et al. 2013

Eur Radiol

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“…However, the study of Bakker et al [23] showed that for reliable calculation of renal size in vitro, MRI with use of the voxel-count method is preferred. Compared to the study of Michielsen et al [2], where the MR-volumetry was performed in 240 fetuses, the range of the kidney volumes in the current study was slightly larger (Table 2). That study [2] however, included only healthy fetal kidneys, while our study involved also fetuses with CAKUT and pregnancies with earlier GA.…”

Section: Renal Imagingcontrasting

confidence: 85%

“…Compared to the study of Michielsen et al [2], where the MR-volumetry was performed in 240 fetuses, the range of the kidney volumes in the current study was slightly larger (Table 2). That study [2] however, included only healthy fetal kidneys, while our study involved also fetuses with CAKUT and pregnancies with earlier GA. In fetuses with CAKUT renal size is not an accurate reflect of the renal function (Beall et al 2007).…”

Section: Renal Imagingcontrasting

confidence: 85%

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Comparison of amniotic fluid volumetry between fetal sonography and MRI - Correlation to MR diffusion parameters of the fetal kidney

Moschos¹,

Güllmar²,

Fiedler³

et al. 2017

Birth Defect

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Objective: Determine whether amniotic fluid volume (AFV) determination by magnetic resonance imaging (MRI) can be compared with ultrasound based amniotic fluid index (AFI) and whether diffusion weighted imaging (DWI) of the fetal kidneys can be used as surrogate marker for the assessment of AFV and fetal kidney function. Methods:In the period from August 2013 to September 2014 prospective evaluation of AFV based on TRUFI MRI in 2 spatial planes (AFVMRI) and ultrasound based AFI. Inclusion criteria for the evaluation were: 1) Full image of the fetus (including AF and placenta) in an MR-study in at least two planes (sagittal and coronal), 2) Layer thickness 8 mm, 3) DWI-images of the fetal kidney in two planes (sagittal and transverse to the fetus). ROI analysis of the ADC values in normal kidneys and in pathological fetal kidneys (CAKUT) as well as the correlation of AFVMRI vs. AFI, renal volume and ADC were performed. Results:The correlation between AFI (13.60 ± 2.46 cm) and AFVMRI (579 ± 353 mL) was 0.69 (p=0.03). There was no significant correlation between AFVMRI and kidney volume, between AFVMRI and ADC700 and ADC800. The B700-ADC values of fetuses with CAKUT (n=14) were considerably higher than the values in fetuses with healthy kidneys. Conclusion:Compared to AFI, AFVMRI showed higher accuracy, but was associated with higher time consumption. Thus it cannot be routinely recommended for the purpose of AFV-determination alone. MRI can be used to establish a relationship between kidney diffusion parameters, renal volume, GA and AFV in fetuses with CAKUT.

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“…Four measurements determined from the mutant cohorts (Glis3‐null with vehicle and Glis3‐null with rapamycin) included: cyst volume; cyst volume percent of the entire kidney; TTP mean in tissue area; and TTP variance in tissue area. Structural changes (kidney volume, cyst volume and cyst percent) and a functional change (TTP mean) were fitted to a polynomial function of second order . TTP variance was fitted to a linear function.…”

Section: Methodsmentioning

confidence: 99%

4D MRI of polycystic kidneys from rapamycin‐treated Glis3‐deficient mice

Xie

Subashi

et al. 2015

NMR in Biomedicine

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Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant lose of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine disease severity and progression. In the present study, we found that while kidney volume and cyst volume decreased with drug treatment, renal function did not improve with treatment. Here, we applied dynamic contrast-enhanced MRI to study PKD in a Glis3-deficient mouse model. Cysts from this model have a wide range of sizes and develop at an early age. To capture this crucial stage and assess cysts in detail, we imaged during early development (3 to 17 weeks) and applied high spatiotemporal resolution MRI (125×125×125 cubic microns every 7.7 seconds). A drug treatment with rapamycin (also known as sirolimus) was applied to determine whether disease progression could be halted. The effect and synergy (interaction) of aging and treatment were evaluated using an analysis of variance (ANOVA). Structural measurements including kidney volume, cyst volume, and cyst-kidney volume ratio changed significantly with age. Drug treatment significantly decreased these metrics. Functional measurements of time-to-peak (TTP) mean and TTP variance were determined. TTP mean did not change with age, while TTP variance increased with age. The treatment of rapamycin generally did not affect these functional metrics. Synergistic effects of treatment and age were not found for any measurements. Together, the size and volume ratio of cysts decreased with drug treatment, while renal function remained the same. Quantifying renal structure and function with MRI can comprehensively assess the pathophysiology of PKD and response to treatment.

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MR volumetry of the normal fetal kidney: reference values

Abstract: The present study provides reference data for normal fetal renal volumes, which may enable to identify fetuses at risk to develop congenital oligonephropathy.

Cited by 13 publications

References 18 publications

Heritability, determinants and reference values of renal length: a family-based population study

Heritability, determinants and reference values of renal length: a family-based population study

Comparison of amniotic fluid volumetry between fetal sonography and MRI - Correlation to MR diffusion parameters of the fetal kidney

4D MRI of polycystic kidneys from rapamycin‐treated Glis3‐deficient mice

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