Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors

Rau, Kristofer K.; McIlwrath, Sabrina L.; Wang, Hong; Lawson, Jeffrey J.; Jankowski, Michael P.; Zylka, Mark J.; Anderson, David J.; Koerber, H. Richard

doi:10.1523/jneurosci.1057-09.2009

Cited by 134 publications

(144 citation statements)

References 38 publications

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“…These data are remarkably consistent with gene-deletion studies (103). The sensitivity of C-MH fibers innervating hairy skin to cold, heat, and mechanical stimuli is reduced in mice constitutively lacking MrgprD-expressing cells reported to be TRPV1 and peptide negative (121). However, when genetic ablation of this population of cells is done in adulthood, behavioral deficits were observed to mechanical but not thermal stimuli (122).…”

Section: Do Labeled Lines Transmit Noxious Stimulus Information?supporting

confidence: 80%

Nociceptors: the sensors of the pain pathway

Dubin

Patapoutian²

2010

J. Clin. Invest.

1,070

856

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Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers. The activation of functionally distinct cutaneous nociceptor populations and the processing of information they convey provide a rich diversity of pain qualities. Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.

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Section: Do Labeled Lines Transmit Noxious Stimulus Information?supporting

confidence: 80%

Nociceptors: the sensors of the pain pathway

Dubin

Patapoutian²

2010

J. Clin. Invest.

1,070

856

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“…The Mrgprb4 gene network in C4-2 could be responsible for detecting gentle touch and massage-like stroking [46,47]. TRPV2, TRPC3, TRPC6 and Piezo2 in C5 may correlate to C4-2's moderate sensitivity to heat and mechanical stimuli and its contribution to nociceptive behavior [47,48].…”

Section: Functional Annotations Of Neuron Types and Related Gene-netwmentioning

confidence: 99%

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

et al. 2015

Cell Res

404

432

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“…The situation is, however, quite different in mice, in which a large subset of CMH neurons does not respond to capsaicin due to a lack of TRPV1 expression (53). Most CMH neurons in mice can be marked by the expression of the G protein-coupled receptor Mrgprd, and these neurons coexpressed P2X3 (53,(64)(65)(66). It was proposed that heat responsiveness of some CMH neurons in mice might be indirectly mediated by chemicals released from keratinocytes (60).…”

Section: Figurementioning

confidence: 99%

Labeled lines meet and talk: population coding of somatic sensations

Ma¹

2010

J. Clin. Invest.

145

121

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The somatic sensory system responds to stimuli of distinct modalities, including touch, pain, itch, and temperature sensitivity. In the past century, great progress has been made in understanding the coding of these sensory modalities. From this work, two major features have emerged. First, there are specific neuronal circuits or labeled lines transmitting specific sensory information from the skin to the brain. Second, the generation of specific sensations often involves crosstalk among distinct labeled lines. These features suggest that population coding is the mechanism underlying somatic sensation.

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Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors

Cited by 134 publications

References 38 publications

Nociceptors: the sensors of the pain pathway

Nociceptors: the sensors of the pain pathway

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

Labeled lines meet and talk: population coding of somatic sensations

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