MRI-based pictorial review of the FIGO classification system for uterine fibroids

Gomez, Erin; Nguyen, My-Linh Thi; Fursevich, Dzmitry; Macura, Katarzyna J.; Gupta, Ayushi P.

doi:10.1007/s00261-020-02882-z

Cited by 33 publications

(18 citation statements)

References 25 publications

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“…Fibroids can be submucosal, intramural, subserosal, hybrid, or nonmyometrial. The FIGO classification system has an essential role in describing and classifying leiomyomas uniformly [ 20 ]. FIGO 2 to 5 classification was observed in 46% of the U500 group, while in the U150 group, prevalence was 12%.…”

Section: Resultsmentioning

confidence: 99%

Metabolomic Profiling of Peripheral Plasma by GC-MS and Correlation With Size of Uterine Leiomyomas

Barison

Izidoro²,

D’Amora

et al. 2022

Journal of the Endocrine Society

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BACKGROUND Uterine leiomyomas are benign monoclonal tumors originating from the myometrium. Little information exists concerning metabolomics and the presence of leiomyomas. OBJECTIVE The present study evaluated circulating metabolites in the plasma, aiming to correlate with presence and size of leiomyomas. STUDY DESIGN Cross-sectional observational study, including women divided into three groups: 37 with leiomyomas and uterus over 500 cm 3, 17 with leiomyomas and uterus up to 150 cm 3, and 21 leiomyoma-free. Patients underwent peripheral blood collection using untargeted metabolic assessment by gas chromatography coupled to mass spectrometer. RESULTS There was no statistical difference between patients’ anthropometric and demographic features and laboratory tests. Statistical differences in uterus volume (p<0.0001) were found. Forty-six metabolites were identified (35% were amino acids and derivatives, 22% fatty acids and 18% carbohydrates). Statistically significant metabolic distinction (p<0.05 and FDR<0.05) was observed for 14 metabolites. Most amino acids (L-isoleucine, L-valine and pyroglutamic acid) were significantly reduced in plasma levels of patients with large leiomyomas. The only exception was L-glutamine, with a significant increase. Fatty acids (arachidonic acid, alfa-tocopherol, palmitic acid and stearic acid) were similarly reduced in large leiomyomas patients, except for alpha-linolenic acid, which increased. For carbohydrates (myo-inositol, D-threitol and D-ribose) there was a decrease in the plasma of patients with leiomyomas. CONCLUSION There are different plasma metabolites levels of amino acids, fatty acids, and carbohydrates among patients with leiomyomas, most of them reduced and significantly more in large leiomyomas compared to leiomyoma-free patients.

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Section: Resultsmentioning

confidence: 99%

Metabolomic Profiling of Peripheral Plasma by GC-MS and Correlation With Size of Uterine Leiomyomas

Barison

Izidoro²,

D’Amora

et al. 2022

Journal of the Endocrine Society

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“…Frontiers in Pharmacology frontiersin.org et al, 2009). Subserosal fibroids tend to be asymptomatic unless they are large, which can cause substantial pressure or pain (Bulun, 2013;Gomez et al, 2021).…”

Section: Figurementioning

confidence: 99%

“…According to the International Federation of Gynecology and Obstetrics (FIGO), uterine fibroids are categorized into eight different subtypes ( Table 1 ). The FIGO categorization also has a type 8, which includes lesions on extrauterine locations such as the cervix or broad ligament ( Gomez et al, 2021 ). Subtypes are determined by the position of the myoma in relation to the endometrial cavity.…”

Section: Locationmentioning

confidence: 99%

Uterine fibroids — Causes, impact, treatment, and lens to the African perspective

et al. 2023

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Leiomyomas, or uterine fibroids as they are commonly known, are mostly seen in women of reproductive age. However, they can go undetected in most women, and approximately 25% of women show clinical symptoms. Although fibroids are a global burden impacting 80% of premenopausal women, they are more prevalent among Black women than among women of other races. Based on clinical diagnosis, the estimated cumulative incidence of fibroids in women ≤50 years old is significantly higher for black (>80%) versus white women (∼70%). The cause of leiomyomas is not clearly known, but studies have shown evidence of factors that drive the development or exacerbation of the disease. Evidence has linked risk factors such as lifestyle, age, environment, family history of uterine fibroids, and vitamin D deficiencies to an increased risk of uterine fibroids, which impact women of African descent at higher rates. Treatments may be invasive, such as hysterectomy and myomectomy, or non-invasive, such as hormonal or non-hormonal therapies. These treatments are costly and tend to burden women who have the disease. Sub-Saharan Africa is known to have the largest population of black women, yet the majority of uterine fibroid studies do not include populations from the continent. Furthermore, the prevalence of the disease on the continent is not well determined. To effectively treat the disease, its drivers need to be understood, especially with regard to racial preferences. This paper aims to review the existing literature and build a case for conducting future research on African women.

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“…Diagnóstico: La ecografía endovaginal es la modalidad de imagen de primera elección para el estudio de los leiomiomas y se apoya en las imágenes obtenidas por resonancia magnética, ya que permiten una evaluación más precisa en casos de lesiones múltiples (7) .…”

Section: Introductionunclassified

“…Existen varios tipos de leiomiomas y es necesaria una correcta clasificación para la planificación del tratamiento y la prevención de complicaciones (7) . La clasificación se basa en la ubicación del tumor en: subserosos (se proyectan fuera del útero), intramurales (dentro del miometrio), de la submucosa (se proyectan hacia la cavidad uterina) y cervicales (8) .…”

Section: Introductionunclassified

Large submucosal leiomyoma. An unusual presentation. Case Report

Simbaña

Mancheno

Arboleda

2022

Rev. Nac. (Itauguá)

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Se ha postulado que más del 70 % de las mujeres antes de la menopausia son diagnosticadas de leiomiomas; de estas un 25 % presentan sintomatología grave. La ecografía es la modalidad de imagen de primera elección para su estudio. Se tiene registros de progresión de leiomiomas a leiomiosarcomas, que conllevan a un mal pronóstico y son responsables de una cuarta parte de las muertes por neoplasias uterinas, con una sobrevida a 5 años que van desde 46-53 %, lo cual incentiva el diagnóstico precoz y eficaz de masas uterinas. El caso reportado es una presentación inusual de um leiomioma de gran tamaño, que por los hallazgos de imagen se reportó como una

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MRI-based pictorial review of the FIGO classification system for uterine fibroids

Cited by 33 publications

References 25 publications

Metabolomic Profiling of Peripheral Plasma by GC-MS and Correlation With Size of Uterine Leiomyomas

Metabolomic Profiling of Peripheral Plasma by GC-MS and Correlation With Size of Uterine Leiomyomas

Uterine fibroids — Causes, impact, treatment, and lens to the African perspective

Large submucosal leiomyoma. An unusual presentation. Case Report

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