MRI characteristics and resectability in spinal cord glioma

Seaman, Scott C.; Bathla, Girish; Park, Brian; Woodroffe, Royce W.; Smith, Mark C.; Menezes, Arnold H.; Noeller, Jennifer; Yamaguchi, Satoshi; Hitchon, Patrick W.

doi:10.1016/j.clineuro.2020.106321

Cited by 6 publications

(12 citation statements)

References 35 publications

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“…After reading titles and abstracts, we retained 40 potentially eligible articles. Among these, 18 studies [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ] were included in the review ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The age range included the entire adulthood; when declared, the male sex ranged from 33% ( n = 1/3 [ 22 ]) to 84.6% ( n = 11/13 [ 23 ]) of the series. As shown in Supplementary Table S1 , the gliomas spinal site in cervical thoracic and lumbar regions ranged from 0% ( n = 0/3 [ 17 ]) to 70% ( n = 7/10 [ 25 ]), from 20% ( n = 2/10 [ 25 ]) to 77% ( n = 10/13 [ 10 ]) and from 0 ( n = 0/13 [ 10 ]; n = 0/24 [ 11 ]; n = 0/22 [ 15 ], n = 0/6 [ 18 ]; n = 0/5 [ 19 ]; n = 0/25 [ 21 ]; n = 0/6 [ 22 ]; n = 0/13 [ 23 ]; n = 0/21 [ 26 ]) to 41% ( n = 5/12 [ 14 ]), respectively. The lesion involved more than one region from 0% cases [ 10 , 15 , 19 , 22 , 24 , 25 , 26 ] to 43% ( n = 10/24 [ 11 ]).…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Supplementary Table S1 , the gliomas spinal site in cervical thoracic and lumbar regions ranged from 0% ( n = 0/3 [ 17 ]) to 70% ( n = 7/10 [ 25 ]), from 20% ( n = 2/10 [ 25 ]) to 77% ( n = 10/13 [ 10 ]) and from 0 ( n = 0/13 [ 10 ]; n = 0/24 [ 11 ]; n = 0/22 [ 15 ], n = 0/6 [ 18 ]; n = 0/5 [ 19 ]; n = 0/25 [ 21 ]; n = 0/6 [ 22 ]; n = 0/13 [ 23 ]; n = 0/21 [ 26 ]) to 41% ( n = 5/12 [ 14 ]), respectively. The lesion involved more than one region from 0% cases [ 10 , 15 , 19 , 22 , 24 , 25 , 26 ] to 43% ( n = 10/24 [ 11 ]). When described, the median segment extension ranged from 2.3 segments [ 10 ] to 4 [ 11 , 17 ].…”

Section: Resultsmentioning

confidence: 99%

“…Clinical data were reported only in few papers, often using no objective scale [ 11 , 13 , 14 , 18 , 20 , 21 , 22 , 25 , 26 ]. Median pre-surgical MMS was described in seven reports [ 10 , 11 , 15 , 16 , 19 , 25 ], and ranged from 1 ( n = 10 [ 25 ]) to 3 ( n = 5 [ 19 ]).…”

Section: Resultsmentioning

confidence: 99%

“…After reading titles and abstracts, we retained 40 potentially eligible articles. Among these, 18 studies [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] were included in the review (Figure 1). Supplementary Table S1 summarizes the characteristics of the included studies.…”

Section: Search Selectionmentioning

confidence: 99%

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Therapeutic Approaches in Adult Primary Spinal Cord Astrocytoma: A Systematic Review

Anghileri

Broggi

Mazzapicchi

et al. 2022

Cancers

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The issue: Gliomas are primary tumors arising from supporting cells of the central nervous system (CNS), usually in the brain. The 2021 World Health Organization (WHO) classifies gliomas as adult-type diffuse gliomas or circumscribed astrocytic gliomas depending on their histology and molecular features. Spinal astrocytic gliomas are very rare, and nowadays no standard of therapy is available. Treatment options are limited: surgery is often not radical, and adjuvant therapies include mostly radiotherapy (RT) or systemic chemotherapy (CHT). There is lack of knowledge about the efficacy and safety of therapies and their multidisciplinary approaches. The aim of the review: A systematic review of the literature from January 2000 to June 2021 was performed, including both clinical trials and observational studies on histological adult primary spinal cord astrocytomas (SCA), with a minimum follow-up of 6 months and reporting the overall survival, progression-free survival or clinical neurological outcome after any therapeutic approach (surgery, RT or CHT). What are the main findings? A total of 1197 citations were identified by the Medline search and additional records; based on our inclusion criteria, 18 studies were included with a total of 285 adult patients. We documented the lack of any clinical trial. What are the conclusions? The available literature data are limited to series/retrospective studies, including heterogeneous patients, i.e., astrocytoma as well as ependymoma or pediatric/adult age, with scanty data on the outcomes of interest. No clinical trials have been run. Due to the rarity of this disease, multicentric clinical trials with molecular investigations are mandatory to better manage such a rare disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Search Selectionmentioning

confidence: 99%

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Therapeutic Approaches in Adult Primary Spinal Cord Astrocytoma: A Systematic Review

Anghileri

Broggi

Mazzapicchi

et al. 2022

Cancers

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Application evaluation of mixed-reality holographic imaging technology in the surgical treatment of spinal cord glioma

Liu

Li²,

Lu³

2022

Pak J Med Sci

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Objectives: To investigate the application effect of mixed reality (MR) holographic imaging technology in the clinical surgical treatment of spinal cord glioma. Methods: The clinical data of 53 patients with spinal cord glioma who underwent surgical treatment in the Neurosurgery Department of our hospital from January 2017 to May 2020 were retrospectively studied. All the patients were divided into two groups according to different assistive technologies during the surgery: the observation group and the control group, with 30 cases and 23 cases respectively. Patients in the observation group received MR holographic imaging technology intraoperatively, while those in the control group received ultrasound. The surgical conditions of the two groups: the rate of complete resection of tumor lesions and the evaluation accuracy of complete resection were compared. Patients were followed up for 12 months in the outpatient department after surgery, and the recovery of postoperative spinal physiological function was evaluated based on imaging review and MMS scale grading, and the recurrence was obtained. Results: There was no statistical significance in the basic clinical conditions between the two groups (P>0.05), and the total tumor resection rate in the experimental group was 96.67%, and that in the control group was 82.61%, showing a statistically significant difference (P<0.05). Based on enhanced MRI examination as the standard, the evaluation accuracy of intraoperative complete tumor resection in the experimental group was 93.33%, significantly higher than that in the control group (73.54%), with a statistical significance (P<0.05). The incidence of postoperative complications was 3.33% in the experimental group and 21.74% in the control group, with a statistically significant difference (P<0.05). Postoperative follow-up showed that good recovery rate of spinal cord function in the experimental group was 56.70%, and that in the control group was 41.09%, with a statistically significant difference (P<0.05). The recurrence rate was 0 in the experimental group and 4.34% in the control group at follow-up, with no statistically significant difference (P>0.05). Conclusions: With the application of MR holographic imaging technology in the surgical treatment of spinal cord glioma, critical clinical value can be realized. Specifically, the resection degree of spinal cord glioma can be displayed in real time, accurately, and three-dimensionally, the effect of surgical resection can be improved, surgical complications can be diminished, and the recovery of spinal cord function can be accelerated. doi: https://doi.org/10.12669/pjms.38.7.4777 How to cite this:Liu Z, Li X, Lu J. Application evaluation of mixed-reality holographic imaging technology in the surgical treatment of spinal cord glioma. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.4777 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Long-term Neurologic Outcome After Spinal Ependymoma Resection With Multimodal Intraoperative Electrophysiological Recording: Cohort Study and Review of the Literature

et al. 2022

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Objective: To evaluate how multimodal intraoperative neuromonitoring (IONM) changes during spinal ependymoma (SE) resection correlate with long-term neuro-functional outcomes.Methods: A retrospective analysis of patients aged 18 years or older who underwent surgical resection for SE over a 10-year period was conducted. IONM changes were defined as sustained transcranial motor evoked potential (TcMEP) and/or somatosensory evoked potential (SSEP) signal decrease of 50% or greater from baseline. Primary endpoints were postoperative modified McCormick Neurologic Scale (MNS) scores at postoperative day (POD) < 2, 6 weeks, 1 year, and 2 years. Univariate and multivariate analyses were performed.Results: Twenty-nine patients were identified. Average age was 44.2 ± 15.4 years. Sixteen (55.2%) were male and 13 (44.8%) were female. Tumor location was 10 cervical-predominant (34.5%), 13 thoracic-predominant (44.8%), and 6 lumbar/conus-predominant (20.7%). A majority (69.0%) were World Health Organization grade 2 tumors. Twentyfour patients (82.8%) achieved gross total resection. Thirteen patients (44.8%) had a sustained documented IONM signal change and 10 (34.5%) had a TcMEP change with or without derangement in SSEP. At POD < 2, 6 weeks, 1 year, and 2 years, MNS was significantly higher for those when analyzing subgroups with either any sustained IONM or TcMEP ± SSEP signal attenuation > 50% below baseline (all p < 0.05).Conclusion: Sustained IONM derangements > 50% below baseline, particularly for TcMEP, are significantly associated with higher MNS postoperatively out to 2 years. Intraoperative and postoperative management of these patients warrant special consideration to limit neurologic morbidity.

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MRI characteristics and resectability in spinal cord glioma

Cited by 6 publications

References 35 publications

Therapeutic Approaches in Adult Primary Spinal Cord Astrocytoma: A Systematic Review

Therapeutic Approaches in Adult Primary Spinal Cord Astrocytoma: A Systematic Review

Application evaluation of mixed-reality holographic imaging technology in the surgical treatment of spinal cord glioma

Long-term Neurologic Outcome After Spinal Ependymoma Resection With Multimodal Intraoperative Electrophysiological Recording: Cohort Study and Review of the Literature

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