MRI contrast-dose relationship of manganese(III)tetra(4-sulfonatophenyl) porphyrin with human xenograft tumors in nude mice at 2.0 T

Metalloporphyrins and Functional Analogues as MRI Contrast Agents

“…However, it was not until the emergence of MRI later in the last century that paramagnetic metalloporphyrins were developed as tumor-seeking MR CAs, which were intended to utilize the tumoral "preferential uptake" property of porphyrins and to take the versatile advantages of MRI [26][27][28][29][30][31][32][33][34][35][36]. A great variety of such CAs, generally with molecular weights under 2k Da, were produced from many centers worldwide, and in vivo imaging studies on different animal species demonstrated that intravenous or intraperitoneal administration of metalloporphyrins enabled a persistent "tumor-specific" CE on MRI [26][27][28][29][30][31][32][33][34][35][36][37].…”

Water exchange rates of water-soluble manganese(iii) porphyrins of therapeutical potential

“…The effective dose for sufficient contrast (at 2 Tesla) is reported to be only five times lower than LD 50 . 25 Therefore, Mn III TSPP 3-is considered useful in radioactive ( 51 Mn) nuclear medicine rather than in MRI. 26 It was also recently shown that Mn III TE-2-PyP 5+ and Mn III TnHex-2-PyP 5+ exhibit powerful potentials as molecular MR imaging probes for the prostate cancer detection and may be particularly effective at selectively detecting multifocal disease in situ.…”

Porphyrin chemistry pertaining to the design of anti-cancer drugs; part 1, the synthesis of porphyrins containing meso-pyridyl and meso-substituted phenyl functional groups

“…Use of such a drug, which first accumulates in tumors, then kill cells via sensitization of the cells to ionizing radiation, may overcome the noted limitations of both radiotherapy and PDT because hypoxic cells might be selectively sensitized and X-rays are known to penetrate tissues well. If appropriate porphyrin compounds can be synthesized, they may also have potential for use in other aspects of cancer treatments and diagnosis, including PDT (7), chemotherapy (8), boron neutron capture therapy (9), and magnetic resonance imaging diagnosis (10). This paper reports the synthesis and characterization of porphyrins containing within meso substituents some functional groups that might possibly be beneficial for DNA binding (-NH2, pyridine), and for radiosensitization ).…”