MRI detects white matter reorganization after neural progenitor cell treatment of stroke

Jiang, Quan; Zhang, Zheng Gang; Ding, Guangliang; Silver, Brian; Zhang, Li; Meng, He; Lü, Mei; Pourabdillah-Nejed-D., Siamak; Wang, Lei; Savant-Bhonsale, Smita; Li, Lian; Bagher‐Ebadian, Hassan; Hu, Jiani; Arbab, Ali S.; Vanguri, Padmavathy; Ewing, James R.; Ledbetter, Karyn A.; Chopp, Michael

doi:10.1016/j.neuroimage.2006.05.025

Cited by 141 publications

(143 citation statements)

References 57 publications

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“…However, some groups have reported increases in FA values near the lesion boundary between 3 and 9 weeks after stroke (van der Zijden et al, 2008), which is enhanced with neural progenitor cell treatment (Jiang et al, 2006), as well as in the ipsilateral striatum around 21 days after stroke (Granziera et al, 2007). The latter two studies also used ex vivo DTI measurements to obtain tractography.…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

“…The latter two studies also used ex vivo DTI measurements to obtain tractography. Abnormal fiber trajectories were identified that originated in the ischemic and projected to the contralateral striatum in a small subset of animals with subcortical infarcts (Granziera et al, 2007), and increased numbers of tracts were observed projecting from the corpus callosum into the injured tissue (Jiang et al, 2006). However, conclusions regarding white matter reorganization must be interpreted cautiously on account of the sensitivity of the measurements and drawbacks with the analysis methods.…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

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Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Farr

Wegener

2010

J Cereb Blood Flow Metab

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Despite promising results in preclinical stroke research, translation of experimental data into clinical therapy has been difficult. One reason is the heterogeneity of the disease with outcomes ranging from complete recovery to continued decline. A successful treatment in one situation may be ineffective, or even harmful, in another. To overcome this, treatment must be tailored according to the individual based on identification of the risk of damage and estimation of potential recovery. Neuroimaging, particularly magnetic resonance imaging (MRI), could be the tool for a rapid comprehensive assessment in acute stroke with the potential to guide treatment decisions for a better clinical outcome. This review describes current MRI techniques used to characterize stroke in a preclinical research setting, as well as in the clinic. Furthermore, we will discuss current developments and the future potential of neuroimaging for stroke outcome prediction.

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Section: Diffusion Tensor Imagingmentioning

confidence: 99%

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Farr

Wegener

2010

J Cereb Blood Flow Metab

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“…Peri-infarct changes include thinning, volume loss, and density loss in histological tissue (Karl et al, 2010), as well as time-dependent normalization of T2 and fractional diffusion anisotropy (van der Zijden et al, 2008b) as identified by magnetic resonance imaging (MRI). It has been proposed that these changes may be indicative of edema resolution (Lin et al, 2002a,b), glial proliferation (Ishii et al, 1998;Wegener et al, 1996), and possibly white matter reorganization or restoration of neuronal connectivity (Jiang et al, 2006;van der Zijden et al, 2008a). In addition, the formation of a cortical infarct has been shown to be necessary for the development of subsequent cortical thinning, as stroke localized to the basal ganglia does not lead to thinning of the overlying cortex (Karl et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis

et al. 2010

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“…Importantly, vascular density can be measured in vivo with imaging techniques that map regional blood volume. Numerous studies have established a tight relationship between angiogenesis and regional blood volume (13-17), including in the brain where regional angiogenesis is coupled to regional cerebral blood volume (CBV) (18)(19)(20)(21)(22)(23)(24)(25)(26).…”

mentioning

confidence: 99%

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

Pereira¹,

Huddleston²,

Brickman³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

1,189

941

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With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time in the hippocampal formation of exercising mice. Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis. Moreover, exercise-induced increases in dentate gyrus CBV were found to correlate with postmortem measurements of neurogenesis. Second, using similar MRI technologies, we generated CBV maps over time in the hippocampal formation of exercising humans. As in mice, exercise was found to have a primary effect on dentate gyrus CBV, and the CBV changes were found to selectively correlate with cardiopulmonary and cognitive function. Taken together, these findings show that dentate gyrus CBV provides an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging.hippocampus ͉ in vivo imaging ͉ cerebral blood volume ͉ angiogenesis T he hippocampal formation, a brain circuit made up of separate but interconnected subregions (1), is vital for memory function (2) and is targeted by the aging process (3). The dentate gyrus is the only hippocampal subregion that supports neurogenesis in the adult brain (4-6). Nevertheless, because neurogenesis can only be assessed in postmortem tissue, its functional significance remains undetermined. With this limitation in mind, we have explored different imaging approaches applicable to rodents and humans that might provide an in vivo correlate of neurogenesis.Although imaging radioligands designed to bind newly dividing cells is an attractive approach, positron emission tomography imaging suffers inherently poor resolution and cannot visualize the dentate gyrus. Additionally, radiolabeling newborn cells introduces potential safety concerns. For these reasons, we have focused on MRI technologies instead. Notably, a coupling has been established between neurogenesis and angiogenesis (7,8). The process of angiogenesis, in turn, gradually gives rise to the formation of new blood vessels, increasing regional microvascular density (9-12). Importantly, vascular density can be measured in vivo with imaging techniques that map regional blood volume. Numerous studies have established a tight relationship between angiogenesis and regional blood volume (13-17), including in the brain where regional angiogenesis is coupled to regional cerebral blood volume (CBV) (18)(19)(20)(21)(22)(23)(24)(25)(26).Because CBV can be measured with MRI, we hypothesized that a regionally selective increase in hippocampal CBV might provide an imaging correlate of neurogenesis. This hypothesis was tested in...

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MRI detects white matter reorganization after neural progenitor cell treatment of stroke

Cited by 141 publications

References 57 publications

Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

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