MRI evaluation of the adaptive response of the contralateral kidney following nephrectomy in patients with renal cell carcinoma

Abstract

In patients with RCC following RN, an early increase in RBF of the contralateral kidney is associated with late renal hypertrophy which might normalize glomerular hyperfiltration and restore renal function.

Quantification of Single-Kidney Function and Volume in Living Kidney Donors Using Dynamic Contrast-Enhanced MRI

“…In general, little is known about the longterm effects of kidney donation on donor renal function compared with the short-term effects, and MRI research on this issue is scarce. Our DCE-MRI results in living kidney donors are consistent with DCE-MRI results showing renal functional adaption in the contralateral kidney after nephrectomy for renal cancer: Su et al [37] reported a 43% and 66% correlational increase in renal blood flow and parenchymal volume, respectively. Adaptive renal response in living kid-ney donors has recently been studied using other MRI techniques, such as ASL [7], DWI [2], and unenhanced MRI [8].…”

Bias and Precision in Magnetic Resonance Imaging‐Based Estimates of Renal Blood Flow: Assessment by Triangulation

“…MRI enables quantification of renal perfusion (expressed in mL/min/100 mL) either by dynamic contrast enhanced (DCE) 3 or by arterial spin labeling (ASL) 4 based approaches. Both MRI methods have demonstrated promising results for detecting kidney dysfunction and evaluating disease progression 5,6 . However, resting perfusion measurements from healthy volunteers reported in the literature vary between the two methods by as much as a factor of 2 (range between 172 and 427 mL/min/100 mL for cortical perfusion using ASL and between 244 and 443 mL/min/100 mL for the whole parenchyma using DCE, see Supplementary File S1), undermining clinical confidence in MRI perfusion measures.…”

“…Both MRI methods have demonstrated promising results for detecting kidney dysfunction and evaluating disease progression. 5,6 However, resting perfusion measurements from healthy volunteers reported in the literature vary between the two methods by as much as a factor of 2 (range between 172 and 427 mL/min/100 mL for cortical perfusion using ASL and between 244 and 443 mL/min/100 mL for the whole parenchyma using DCE, see Supplementary File S1), undermining clinical confidence in MRI perfusion measures. While differences in demographics, subject preparation, and physiological variations play a role, 7 the effect of measurement error cannot be excluded.…”