MRI findings of radiation-induced myocardial damage in patients with oesophageal cancer

Umezawa, Rei; Ota, Hideki; Takanami, Kentaro; Ichinose, Azusa; Matsushita, Haruo; Saito, Hiroshi; Takase, Kei; Jingu, Keiichi

doi:10.1016/j.crad.2014.08.010

Cited by 48 publications

(45 citation statements)

References 26 publications

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“…The tolerance dose of myocardium is estimated to be 30-40 Gy. 2, 3 In contrast, in the present case there was no dermatitis during follow-up, although the risk of severe skin damage such as ulceration increases at >40-45 Gy. 5 Thus, the adverse effects of RTx might depend on the susceptibility of each organ.…”

Section: Kawamura G Et Alcontrasting

confidence: 44%

“…4 Late gadolinium enhancement has been detected in half of patients who received RTx for esophageal cancer. 3 The present patient did not develop myocardial fibrosis. The tolerance dose of myocardium is estimated to be 30-40 Gy.…”

Section: Kawamura G Et Almentioning

confidence: 68%

“…1,2 Diagnosis of radiationinduced cardiomyopathy is challenging and usually is a diagnosis of exclusion. Therefore, diagnosis of radiationinduced cardiomyopathy needs multimodality assessment using echocardiography, 2 cardiac MRI, 3 and myocardial perfusion imaging. 4 Late gadolinium enhancement has been detected in half of patients who received RTx for esophageal cancer.…”

Section: Kawamura G Et Almentioning

confidence: 99%

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Radiation-Induced Cardiomyopathy Incidentally Detected on Oncology <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography

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Section: Kawamura G Et Alcontrasting

confidence: 44%

Section: Kawamura G Et Almentioning

confidence: 68%

Section: Kawamura G Et Almentioning

confidence: 99%

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Radiation-Induced Cardiomyopathy Incidentally Detected on Oncology <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography

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et al. 2018

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“…However, many of the pathological processes that give rise to fibrosis and LGE are also associated with increased autophagy, including scleroderma 80, 81 , heart failure 82, 83 , radiation-induced myocardial injury 84, 85 , Friedreich ataxia 86, 87 , and Fabry disease 88, 89 . It is possible that some instances of LGE are due to upregulation of autophagy rather than fibrosis or macrophage activity, but this will need to be formally tested.…”

Section: Methods To Measure Autophagy and Mitophagymentioning

confidence: 99%

Untangling Autophagy Measurements

Gottlieb

Andres

Sin

et al. 2015

Circulation Research

134

105

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Autophagy is an important physiological process in the heart, and alterations in autophagic activity can exacerbate or mitigate injury during various pathological processes. Methods to assess autophagy have changed rapidly as the field of research has expanded. As with any new field, methods and standards for data analysis and interpretation evolve as investigators acquire experience and insight. The purpose of this review is to summarize current methods to measure autophagy, selective mitochondrial autophagy (mitophagy), and autophagic flux. We will examine several published studies where confusion arose in in data interpretation, in order to illustrate the challenges. Finally we will discuss methods to assess autophagy in vivo and in patients.

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“…35 Dynamic contrast enhanced MRI has been shown to be useful in evaluating late cardiac toxicity due to radiation therapy. 56 MRI is extremely useful in guidance of brachytherapy insertions as well as post-implant evaluation. [57][58][59][60] MR as an on-board image modality carries the inherent advantages (high contrast, functional information, better tumour and normal tissue discrimination) to image guidance.…”

Section: Biomarkers and Mrimentioning

confidence: 99%

The future of image-guided radiotherapy will be MR guided

Pollard

Wen

Sadagopan

et al. 2017

BJR

168

133

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Advances in image-guided radiotherapy (RT) have allowed for dose escalation and more precise radiation treatment delivery. Each decade brings new imaging technologies to help improve RT patient setup. Currently, the most frequently used method of three-dimensional pre-treatment image verification is performed with cone beam CT. However, more recent developments have provided RT with the ability to have on-board MRI coupled to the teleradiotherapy unit. This latest tool for treating cancer is known as MR-guided RT. Several varieties of these units have been designed and installed in centres across the globe. Their prevalence, history, advantages and disadvantages are discussed in this review article. In preparation for the next generation of image-guided RT, this review also covers where MR-guided RT might be heading in the near future.

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MRI findings of radiation-induced myocardial damage in patients with oesophageal cancer

Cited by 48 publications

References 26 publications

Radiation-Induced Cardiomyopathy Incidentally Detected on Oncology <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography

Radiation-Induced Cardiomyopathy Incidentally Detected on Oncology <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography

Untangling Autophagy Measurements

The future of image-guided radiotherapy will be MR guided

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