MRI of cervical spinal cord infarction in a patient with sickle cell disease

Márquez, Juan Camilo; Granados, Ana; Castillo, Maurício

doi:10.1016/j.clinimag.2011.12.013

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…In children, the most common causes are cardiac malformations and trauma. In adults, atheromatosis is one the principal causes, but thoracoabdominal aneurysms, aortic surgery, 2 embolic disease, dissection, systemic hypotension, spinal arteriovenous malformations, diving, 3 coagulopathies, cocaine, 4 sickle cell disease, 5 and idiopathic causes are also implicated.…”

mentioning

confidence: 99%

Spinal Cord Ischemia: Practical Imaging Tips, Pearls, and Pitfalls

Vargas¹,

Gariani²,

Sztajzel

et al. 2014

AJNR Am J Neuroradiol

162

121

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SUMMARY:Ischemia of the spinal cord is a rare entity with a poor prognosis. Brain ischemia is no longer a diagnostic challenge; on the contrary, ischemia of the spinal cord remains difficult, particularly in children. In this article, we illustrate the principal causes in children and adults, clinical presentation, different techniques for the diagnosis by MR imaging (diffusion, spinal MR angiography, and 1.5 versus 3T), pathophysiology, and differential diagnosis. We will discuss current knowledge, perspectives, and pitfalls.

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mentioning

confidence: 99%

Spinal Cord Ischemia: Practical Imaging Tips, Pearls, and Pitfalls

Vargas¹,

Gariani²,

Sztajzel

et al. 2014

AJNR Am J Neuroradiol

162

121

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“…To the best of our knowledge, there are only two reported cases of other persons, both now deceased, detailing this pathology [4,5]. Of note, the radiographic findings from our patient have been previously presented in a radiology journal with emphasis on the diffusion-weighted images, but in this report we describe the clinical details and our patient’s subsequent course [6]. …”

Section: Discussionmentioning

confidence: 73%

“…These include: intra-cranial hemorrhage, isolated neuropathies, transverse myelitis, auditory and ocular manifestations, and spinal cord involvement [1]. In the spinal cord there has been a description of cord compression by extramedullary hemopoietic tissue in addition to rare case reports of spinal cord infarction [1,4-6]. …”

Section: Introductionmentioning

confidence: 99%

A 19-year-old man with sickle cell disease presenting with spinal infarction: a case report

et al. 2013

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IntroductionVasculopathy of the large vessels commonly occurs in sickle cell disease, and as a result cerebral infarction is a well characterized complication of this condition. However, spinal infarction appears to be rare. Spinal infarct is infrequent in the non-sickle cell population as well, and accounts for only about 1 percent of all central nervous system infarcts.Case presentationIn the present work, we report the case of a 19-year-old African-American man with sickle cell disease who experienced an anterior spinal infarct and subsequent quadriplegia. He was incidentally noted to be a heterozygote for factor V Leiden. We also reviewed the literature and found two previous cases of spinal cord infarction and sickle hemoglobin. Our literature search did not demonstrate that heterozygocity for factor V Leiden plays an important role in spinal cord infarction.ConclusionsThe paucity of cases associated with sickle hemoglobin does not allow us to postulate any particular risk factors with sickle cell disease that might predispose patients to spinal cord infarction. Our patient’s case raises the question as to whether spinal cord infarction is being missed in individuals with sickle cell disease and neurologic symptoms.

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“…It has also been reported in neuromyelitis optica (Devic's disease) , paraneoplastic myelopathies and Hopkins syndrome . A wide range of ischaemic mechanisms have been linked to the snake eyes sign, including sickle cell disease , decompression sickness , cocaine use , ‘steal’ syndromes secondary to arteriovenous malformations and vasculitis , and also iatrogenic effects, such as intraoperative complications or central‐line insertion . The snake eyes sign has been observed at cervical , thoracic , both cervical and thoracic levels and along the entire spinal cord .…”

Section: Introductionmentioning

confidence: 99%