2021
DOI: 10.1126/scitranslmed.abj9827
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mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent

Abstract: An Ixodes scapularis saliva mRNA vaccine induces tick resistance and prevents Borrelia burgdorferi infection in guinea pigs.

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Cited by 93 publications
(77 citation statements)
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“…Because of its immunosuppressive effect on the host, Salp15 plays a major role in sustained tick blood-feeding and in the transmission of tick-borne pathogens. Salp15 is one of the 19 I. scapularis salivary protein genes included in a recent mRNA vaccine that induces tick resistance and prevents transmission of the Lyme disease agent in guinea pigs [ 13 ]. The immunosuppressive properties of Salp15 make it also an interesting candidate for therapeutic applications in immune disorders [ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…Because of its immunosuppressive effect on the host, Salp15 plays a major role in sustained tick blood-feeding and in the transmission of tick-borne pathogens. Salp15 is one of the 19 I. scapularis salivary protein genes included in a recent mRNA vaccine that induces tick resistance and prevents transmission of the Lyme disease agent in guinea pigs [ 13 ]. The immunosuppressive properties of Salp15 make it also an interesting candidate for therapeutic applications in immune disorders [ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…Encouragingly, a multivalent mRNA vaccine encoding 19 salivary proteins (19ISP) from Ixodes scapularis black-legged ticks (which can transmit many pathogens that cause human disease, including the Lyme disease agent Borrelia burgdorferi) has been recently developed [118]. Guinea pigs immunized with lipid nanoparticle-containing nucleosidemodified mRNAs encoding 19ISP elicited a strong specific antibody response and induced protection against tick challenge through the provision of robust tick immunity, which included early erythema after tick placement on the animals and rapid tick detachment, along with severely impaired tick feeding and low engorgement weights [118]. This study provides solid evidence to show that the goal of developing a multivalent mRNA vaccine targeting multiple genes against multicellular organisms (including the schistosomes) is achievable.…”
Section: Mrna Vaccine Technology: Forging New Frontiers In Vaccine Ca...mentioning
confidence: 99%
“…While chemical acaricides such as pyrethroids and organophosphates are mainstay of tick control, the potential of botanical acaricides as an adequate repellant has also been assessed [104]. However, resistance is an increasingly pressing issue and additional integrated tick control measures such as landscape management [105], vaccines targeted for humans [106], deer and rodent targeted vaccines [105,107], and personal protection measures (PPM) need to be taken to adequately control tick populations.…”
Section: Tick Controlmentioning
confidence: 99%