MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production

Abstract

Mitochondrial fission process 1 (MTFP1) is a novel nuclear‐encoded protein that promotes mitochondrial fission. Increasing lines of evidence indicate that increased mitochondrial fission is involved in carcinogenesis and tumor progression. However, the expression and biological effects of MTFP1 in cancer development is still unclear, especially in oral squamous cell carcinoma (OSCC). In this study, we first evaluated the expression of MTFP1 in 12‐paired OSCC tumor and peritumor tissues. We then explored the effects of MTFP1 knockdown or overexpression on cell growth by cell proliferation, colony formation, cell cycle, and cell apoptosis assays. Furthermore, the mechanisms by which MTFP1 promoted OSCC cell growth were explored. Our results showed that MTFP1 is frequently overexpressed in OSCC tissues. Functional experiments revealed that MTFP1 promoted the growth of OSCC cells by inducing the progression of cell cycle and suppressing cell apoptosis. Mechanistically, MTFP1 overexpression‐mediated mitochondrial fragmentation and subsequent ROS production was found to be involved in the promotion of OSCC cell growth. Collectively, our study demonstrates that MTFP1 plays a critical oncogenic role in OSCC carcinogenesis, which may serve as a potential therapeutic target in the treatment of this malignance.

Evidence of Mitochondrial Dysfunction in Bacterial Chondronecrosis With Osteomyelitis–Affected Broilers

“…MTFR1 overexpression has been shown to promote mitochondrial fission (33). MTFP1 overexpression has been linked to increased ROS production and it has been shown to aid in mitochondrial recruitment of DNM1 along with MFF1 (34)(35)(36)(37). These results show a decreased expression of a significant inner membrane fission factor OPA1 and point to potential fission/fragmentation of mitochondrial networks in BCO.…”

LncRNA–mRNA expression profile and functional network of vascular dysfunction in septic rats

“…We found that MTFP1 was the top down-regulated DE mRNA. MTFP1 is a nuclear-encoded protein that promotes mitochondrial fission and is closely related to mitochondrial fission and fusion [ 21 ]. Mitochondrial fragmentation often occurs in dysfunctional mitochondria, resulting in decreased ATP production [ 22 ].…”

Effect of TTLL12 on tubulin tyrosine nitration as a novel target for screening anticancer drugs<em> in&nbsp;vitro</em>

“…Thus, there is an urgent need to identify and develop novel effective treatment for OSCC. The occurrence and development of OSCC is a complex biological process ( 19 ), in which the overexpression of oncogenes (for example Notch1, fibroblast growth factor receptor 4 and c-myc plays an important role ( 20 , 21 ). Recently, a novel gene called tubulin tyrosine ligase like 12 (TTLL12) has demonstrated great interest.…”