MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis

Zhong, Guping; Luo, Xin; Li, Ji; Liao, Yuanhang; Gui, Guan; Sheng, Jianwen

doi:10.1177/03000605221097486

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…The inconsistent results may be explained by racial differences, differences in study design, and the presence of bias. In addition, several studies con rmed that MTRR gene polymorphisms were also associated with a variety of cancers [33][34][35], reproductive disorders[36] and cleft lip and palate [37]. However, most of the previous studies only focused on two loci (i.e., rs1801394 and rs1532268).…”

Section: Discussionmentioning

confidence: 99%

Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population

Li,

Ou,

Chen

et al. 2023

Preprint

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Background Although many studies shown that the risk of congenital heart disease (CHD) was closely related to genetic and environmental factors, the exact mechanism was still unclear. This study was to assess the association of maternal folic acid supplementation (FAS), the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene polymorphisms in offspring and their interactions with the risk of CHD and its subtypes. Methods A case-control study was conducted on 595 children with CHD and 605 healthy child controls. The multivariate logistic regression model was used to assess the association of maternal FAS, offspring MTRR gene polymorphisms and their interactions with CHD and its subtypes. Results This study shown that maternal FAS was significantly associated with a reduced risk of CHD (OR = 0.55, 95%CI: 0.36–0.83) and its subtypes including ASD (OR = 0.25, 95%CI: 0.14–0.45), VSD (OR = 0.42, 95%CI: 0.27–0.64), and CTD (OR = 0.23, 95%CI: 0.09–0.59) in offspring. Offspring MTRR gene polymorphisms at rs162048 (GG vs AA: OR = 2.05, 95%CI: 1.35–3.13), rs1802059 (AA vs GG: OR = 5.13, 95%CI: 2.15–12.23; GA vs GG: OR = 1.81, 95%CI: 1.35–2.43), rs10380 (TT vs CC: OR = 2.27, 95%CI: 1.20–4.31) and rs1801394 (GG vs AA: OR = 1.58, 95%CI: 1.02–2.42) were significantly associated with the risk of CHD, and similar results were also found for three subtypes of CHD. Additionally, a statistically significant interaction between maternal FAS and offspring MTRR gene polymorphism at rs1802059 was observed (OR = 0.38, 95%CI: 0.15–0.94). Among children who had a variant genotype at rs1802059, the risk of CHD was significantly decreased when their mother used folate for this pregnancy compared with mothers not using folate. Conclusions In those of Chinese descent, maternal FAS and offspring MTRR gene polymorphisms are significantly associated with the risk of CHD and its three subtypes. Furthermore, maternal FAS may help to offset some of risks of CHD due to offspring MTRR genetic variants. However, more studies with prospective designs and larger samples are needed to confirm our findings. Trial registration: Registration number: ChiCTR1800016635; Registration time: 14/06/2018.

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Section: Discussionmentioning

confidence: 99%

Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population

Li,

Ou,

Chen

et al. 2023

Preprint

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“…Statistical heterogeneity among studies was evaluated using I 2 statistics (ranges from 0 to 100 %), λ 2 test, and P -values. [ 17 ] The fixed effects model method was used, except when a significant Q test ( P < .05) or I 2 > 50 % indicated the existence of heterogeneity among studies, when it was indicated the existence of heterogeneity, the random effects model was applied. [ 17 ] Heterogeneity was also explored in subgroup analysis with ethnic groups (Asian and Caucasian).…”

Section: Methodsmentioning

confidence: 99%

“…[ 17 ] The fixed effects model method was used, except when a significant Q test ( P < .05) or I 2 > 50 % indicated the existence of heterogeneity among studies, when it was indicated the existence of heterogeneity, the random effects model was applied. [ 17 ] Heterogeneity was also explored in subgroup analysis with ethnic groups (Asian and Caucasian). Funnel plots were drawn to estimate the potential publication bias, in which the standard error of log (OR) of each study was plotted against its log (OR).…”

Section: Methodsmentioning

confidence: 99%

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Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers

Zhong,

Luo,

et al. 2023

Medicine

Self Cite

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Objective: Single nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results. Methods: We performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC. Results: Pooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.27, 95% CI = 1.04–1.55, P heterogeneity = 0.18, P = .02), recessive model (OR = 1.44, 95% CI = 1.04–2.01, P heterogeneity = 0.19, P = .03) among Caucasians; but decreased GC risk under the allele comparison model (OR = 0.89, 95% CI = 0.81–0.98, P heterogeneity = 0.22, P = .02) and dominant model (OR = 0.82, 95% CI = 0.72–0.93, P heterogeneity = 0.15, P = .01) among Asian. Conclusion: Our meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.

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“…The MTRR gene codes methionine synthase reductase (MTRR) enzyme,[ 9 ] which is necessary for the regeneration of functional methionine synthase (MS) by reductive methylation in which the methyl donor is S-adenosylmethionine (SAM). The prevalent SNP in the MTRR gene is the substitution of G for A at position 66 which causes isoleucine to methionine substitution.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in Maternal Selected Folate Metabolism-Related Genes in Neural Tube Defect-Affected Pregnancy

Dewelle,

Melka,

Aklilu

et al. 2023

Advanced Biomedical Research

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Background: Neural tube defects (NTDs) are abnormalities of the brain and spinal cord, which occur as a result of failure in neural tube closure during embryogenesis. Causes of NTDs are complex and multiple, with hereditary, lifestyle, and environmental factors appearing to play a role. In spite of their impact on public health, the role genetics play on NTDs in Ethiopia is lacking. In this study, the role of polymorphisms in MTHFR 677C > T (rs1801133), MTHFR 1298A > C (rs1801131), MTRR 66A > G (rs1801394), RFC1 80A > G (rs1051266), and TCN2 776C > G (rs1801198) on the risk of having NTD-affected pregnancy was investigated. Materials and Methods: One hundred women with NTD-affected pregnancy and 100 women with normal pregnancy were included in the study. DNA was extracted from saliva and genotyping for five polymorphisms in four genes was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The departure of the genotype's distribution from Hardy–Weinberg equilibrium (HWE) was evaluated using the x 2 goodness-of-fit test. Frequencies of genotypes and alleles in case and control mothers were determined and differences between relative frequencies were evaluated by the x 2 or the Fisher's exact test. Results: The statistically significant difference was absent in the genotype and allele frequencies for all the analyzed polymorphisms between cases and controls ( P > 0.05). Conclusion: MTHFR 677C > T, MTHFR 1298A > C, MTRR 66A > G, RFC1 80A > G, and TCN2 776C > G polymorphisms lack association with the risk of having a pregnancy affected by NTD. The role of other genes or environmental factors in NTD etiology needs to be investigated.

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MTRR rs1532268 polymorphism and gastric cancer risk: evidence from a meta-analysis

Cited by 5 publications

References 21 publications

Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population

Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population

Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers

Polymorphisms in Maternal Selected Folate Metabolism-Related Genes in Neural Tube Defect-Affected Pregnancy

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