1994
DOI: 10.1523/jneurosci.14-06-03842.1994
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mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein

Abstract: It has recently been shown that the activation of mu-opioid receptors inhibits several components of calcium channel current in rat DRG sensory neurons. mu-Opioid receptors, acting through the pertussis toxin (PTX)-sensitive substrate Gi, also reduce the activity of neuronal adenylate cyclase, but the relationship of this effect to changes in calcium channel activity has yet to be determined. Using whole-cell recordings from acutely isolated rat DRG neurons, we examined the ability of the mu-opioid-selective a… Show more

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Cited by 99 publications
(60 citation statements)
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“…Distinct G-protein subtypes serve to transduce activation of various GPCRs. For instance, G i/o transduces the norepinephrine receptor 4,11) , ␥-aminobutyric acid receptor 4) , opioid receptor 33) , serotonin receptor 10) , and somatostatin receptor-modulation 11,21) of VDCCs. G q/11 transduces the muscarinic receptor 23) , neurokinin receptor 23) , and angiotensin II receptormodulation 40) of VDCCs.…”
Section: Discussionmentioning
confidence: 99%
“…Distinct G-protein subtypes serve to transduce activation of various GPCRs. For instance, G i/o transduces the norepinephrine receptor 4,11) , ␥-aminobutyric acid receptor 4) , opioid receptor 33) , serotonin receptor 10) , and somatostatin receptor-modulation 11,21) of VDCCs. G q/11 transduces the muscarinic receptor 23) , neurokinin receptor 23) , and angiotensin II receptormodulation 40) of VDCCs.…”
Section: Discussionmentioning
confidence: 99%
“…Antibodies directed against the C termini of the a subunits of Gi1/Gi2, GO3, and Gi3/Go (Gi, inhibitory guanine nucleotidebinding regulatory protein; Go, guanine nucleotide-binding regulatory protein) were obtained from Calbiochem and antibodies against the N terminal of the a-subunit of Go were obtained from DuPont/NEN. These antibodies were chosen because antibodies directed against the C termini of the a-subunits of G proteins (22) and against the N terminus of the a-subunit of Go (23) …”
Section: Methodsmentioning
confidence: 99%
“…Activation of μ-, δ-, κ-, and ORL1-opioid receptors inhibits VGCCs in dissociated DRG neurons (Moises et al, 1994a;Moises et al, 1994b;Acosta and Lopez, 1999;Beedle et al, 2004). For example, both morphine and DAMGO have been demonstrated to selectively inhibit N-type and P/Q-type Ca 2+ channels in DRG neurons (Schroeder et al, 1991;Schroeder and McCleskey, 1993;Wu et al, 2004).…”
Section: Effect Of Opioid Receptor Agonists On Ion Channelsmentioning
confidence: 99%