mu-Opioid Receptor Polymorphisms and Breast Cancer Recurrence in Adult Korean Women Undergoing Breast Cancer Surgery: A Retrospective Study

Abstract

Background: Genetic variations of mu-opioid receptors are well known to contribute to growth and progression of tumors. The most common single-nucleotide polymorphism (SNP) in the mu-opioid receptor 1 gene (OPRM1) is the A118G mutation. We examined the association between the recurrent breast cancer and genotypes of OPRM1 A118G SNP (AA vs. AG vs. GG) in Korean women population. Methods: We analysed medical records and genetic data of 200 patients aged more than 20 who underwent primary breast cancer surgery from June 2012 to June 2014 and diagnosed recurrent breast cancer from June 2012 to September 2019. Results: The incidence of recurrent breast cancer was 6.1%, 8.2%, and 4.8% in genotype AA, AG and GG, respectively ( p =0.780). The incidence of recurrent breast cancer in volatile anaesthesia group was 7.0% and 7.1% in total intravenous anaesthesia (TIVA) group (RR = 0.984, 95% CI = 0.328 - 2.951; p = 0.978). Conclusion : OPRM1 A118G SNP had no influence on breast cancer recurrence in Korean women. Anaesthesia technique did not show significant effect on the incidence of recurrent breast cancer.

Effect of Stereotactic Body Radiation Therapy Combined with Thermoplastic Fixation on Set-Up Errors in Breast Cancer Patients Undergoing Radiotherapy

“…The thermoplastic fixation makes up for the deficiencies of conventional fixation. The head mask and baseplate in the thermoplastic fixation can effectively fix the patients to make them feel comfortable and safe during treatment, and the groove and fixing lugs in the baseplate not only facilitate the fixation of headrest but also increase the comfort level [21][22][23]. Besides, Tokunaga et al [24] have pointed out that thermoplastic fixation has remarkably smaller set-up errors compared with the breast bracket and can effectively enhance radiotherapy effect and benefit the patients' prognoses.…”

Effect of Inhalation Anesthetics on Tumor Metastasis

“…Some of these studies have shown that inhalation anesthesia does not affect the prognosis of cancer patients after surgery. In certain types of surgery, such as digestive cancer, 101 breast cancer, 87,89–95 high-grade glioma, 113 colorectal cancer, 96,99 colon cancer, 25 oral cancer, 115 and gastric cancer, 102 there was no significant difference between inhalation anesthetics and propofol in tumor patients immunity, circulating tumor cells, or survival outcomes. Consistent with these results, after anesthesia with desflurane or isoflurane in glioblastoma, the survival rate after surgery is similar, and the addition of propofol is not associated with longer survival.…”

Clinical Value of Total Intravenous Anesthesia with Sufentanil and Propofol in Radical Mastectomy

“…(3) patients allergic to drugs involved in the study; (4) patients with long-term administration of analgesics or sedatives; (5) patients with severe anemia; (6) patients with a history of acute and chronic respiratory diseases; and (7) those in pregnancy or lactation.…”

“…Breast cancer (BC) is a type of cancer caused by the uncontrolled proliferation of mammary epithelial cells, and its incidence ranks first among female tumors worldwide [1], with 52.9% occurring in developing countries [2]. As the most populous developing country, China has the highest number of new BC patients in the world each year and the number of patients needing radical mastectomy increases yearly [3,4]. Since radical mastectomy is a body surface surgery with significant trauma and has a major impact on the respiratory system and circulatory system of patients, there is a clinical need for highly effective anesthesia modalities with good analgesic effects, such as total intravenous anesthesia [5].…”