Mucin-secreting cells in rats infected with Nippostrongylus brasiliensis

Wells, Phyllis D.

doi:10.1016/0014-4894(63)90004-3

Cited by 35 publications

(21 citation statements)

References 9 publications

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“…The possibility that T cells can regulate mucosal epithelial differentiation has not been seriously considered although there is evidence that they might induce villous atrophy in certain disease situations [2], However, in a recent study of goblet cell differentiation, we have found [6], in agree ment with a previous report [13], that gob let cells increase in number prior to and during worm expulsion in primary infec tions with N. brasiliensis. Moreover, goblet cell differentiation was accelerated by adop tive immunization with immune thoracic duct lymphocytes (TDL) in infected, but not in uninfected, control rats [6], and the ex tent of this differentiation process was pro portional to the number of immune TDL transferred [6].…”

supporting

confidence: 76%

Intestinal Goblet Cell Differentiation in Nippostrongylus-Infected Rats after Transfer of Fractionated Thoracic Duct Lymphocytes

Miller

Nawa

Parish³

1979

Int Arch Allergy Immunol

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Adoptive immunization of Nippostrongylus-infected rats augmented goblet cell differentiation in the intestinal epithelium. After fractionation of immune thoracic duct lymphocytes (TDL), cells lacking surface immunoglobulin (sIg––) were the most potent stimulators of goblet cell differentiation. Moreover, TDL drained from rats harbouring a primary infection were more effective than TDL from hyperimmune rats.

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supporting

confidence: 76%

Intestinal Goblet Cell Differentiation in Nippostrongylus-Infected Rats after Transfer of Fractionated Thoracic Duct Lymphocytes

Miller

Nawa

Parish³

1979

Int Arch Allergy Immunol

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“…ceylanicum larvae was similar to that seen dur ing a primary infection of rats with N. brasiliensis [18,26]. The results in these infections are defined more clearly than when mice were infected with the muco sal-dwelling 5. ratti [4] which may indicate that goblet cell hyperplasia is influenced more by lumen-dwell ing nematodes.…”

Section: Discussionsupporting

confidence: 56%

Kinetics of Cells in the Intestinal Mucosa of Mice following Oral Infection with Ancylostoma ceylanicum

Carroll¹,

Grove²,

Heenan

1986

Int Arch Allergy Immunol

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A variety of cell types in the intestinal mucosa of mice has been observed following oral infection with Ancylostoma ceylanicum and the changes in their numbers quantified. The number of lamina propria mast cells increased following infection and reached a peak at 4 days; by 21 days the numbers had returned to normal levels. Globule leucocytes displayed a similar marked response but the numbers returned to within normal limits 7 days after infection. Granular intraepithelial lymphocytes did not alter significantly during the period of observation whereas non-granular intraepithelial lymphocytes declined in numbers following infection and were significantly decreased by 3 weeks. Goblets cells showed a similar response to infection as lamina propria mast cells and reached a peak level at 4 days. Following initial fluctuations in eosinophil numbers there was a substantial increase in the numbers of these cells with peak levels being reached at 21 days; eosinophil numbers then remained elevated for the duration of observation. Partial villous atrophy was seen 4 days after the arrival of larvae in the small intestine with maximum reduction in the length of villi at 7 days. Thereafter, there was a return to normal length followed by a significant elongation in villus length 28 days after infection. The influences of these various cell types on the expulsion of intestinal parasites are discussed.

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“…Infected sheep on LP diets also failed to produce an elevated mast and mucin cell response shown by the well fed animals. Moreover, both the present studies and those of Wells (1962Wells ( , 1963 indicated that the mast cell responses of non-infected, low-protein fed animals differed from those of non-infected, adequately fed animals which may be important in view of the proposed relationship between mast cells and their effect on the release of mucus into the gut (Magee, 1962). This could exacerbate the inability of mucin cells to multiply after the gut is infected in hosts fed low-protein diets, by depleting the secretory capacity of existing cell populations.…”

Section: Discussionmentioning

confidence: 56%

Studies on the immunity of sheep toOesophagostomum columbianum: effects of low-protein diet on resistance to infection and cellular reactions in the gut

Dobson

Bawden

1974

Parasitology

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Adult Oesophagostomum columbianum populations were larger in sheep fed low-protein diets than in adequately fed animals. Diet did not influence the numbers of larva which became established in sheep. Sheep fed high-protein diets eliminated more worms and were more immunologically competent than poorly fed animals. More encapsulated larvae, showing arrested development, were found in adequately fed sheep than in those fed low-protein diets. Adult 0. columbianum produced eggs at an earlier time after infection in poorly fed sheep than worms in well fed sheep. More eggs/female worm were produced in sheep on a low-protein diet compared with the number of eggs produced in well fed hosts over the last week of the infection. The effects of immunity on the behaviour of the worm in both host diet groups is discussed.There was a greater cellular proliferation in the intestines of infected adequately fed sheep than in infected animals on low-protein diets. These changes were most pronounced in the large intestine where the adult parasites were found. The macrophage-lymphocyte series of cells underwent hyperplasia in well fed animals but these changes were reduced, particularly among the plasma cells, in sheep fed low-protein diets. Increased mucin and mast cell counts were observed in sheep on high-protein, but not in hosts on low-protein diets: the intestinal populations of eosinophil and globule leucocytes were also reduced in poorly fed sheep.The relationship of these various cellular reactions and their effect on the protective immunity of sheep to 0. columbianum is discussed. It was concluded that the increased susceptibility of protein deprived sheep to 0. columbianum infections was associated with malfunctions of the innate immunity of the gut, involving decreased peristalsis and failure of the mucin cell response, and with reduction of the adaptive immune response which was reflected by impoverished lymphocyte and plasma cell reactions, and possibly with poor cooperation between sensitized lymphocytes, antibodies and the mast cell-granulocyte effector mechanisms in protective immunity. 240 COLIN DOBSON AND RICHARD J. BAWDEN

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Mucin-secreting cells in rats infected with Nippostrongylus brasiliensis

Cited by 35 publications

References 9 publications

Intestinal Goblet Cell Differentiation in <i>Nippostrongylus</i>-Infected Rats after Transfer of Fractionated Thoracic Duct Lymphocytes

Intestinal Goblet Cell Differentiation in <i>Nippostrongylus</i>-Infected Rats after Transfer of Fractionated Thoracic Duct Lymphocytes

Kinetics of Cells in the Intestinal Mucosa of Mice following Oral Infection with <i>Ancylostoma ceylanicum</i>

Studies on the immunity of sheep toOesophagostomum columbianum: effects of low-protein diet on resistance to infection and cellular reactions in the gut

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