Mucinous adenocarcinoma in association with hidradenitis suppurativa: a new example of isoscartopic response

Vita, Valerio De; Ruocco, Eleonora

doi:10.1111/ced.13338

Cited by 5 publications

(4 citation statements)

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“…Finally, although squamous cell carcinoma is relatively rare, it has been reported as one of the most severe complications of HS, with a mortality rate of approximately 50% among HS patients. It has been hypothesized that the development of epithelial malignancies in the context of chronic HS may be due to an impaired local immunity [ 23 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

The Comorbidity Burden of Hidradenitis Suppurativa in the United States: A Claims Data Analysis

Kimball

Sundaram

Gauthier

et al. 2018

Dermatol Ther (Heidelb)

115

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IntroductionPrior studies have reported that hidradenitis suppurativa (HS) is accompanied by a myriad of physical and mental conditions. However, given the small sample sizes and the limited number of pre-selected comorbidities, these studies do not provide a complete picture of the comorbidity burden of HS in the USA. Moreover, the relationship between HS severity and comorbidity burden has yet to be characterized. Using a large US claims database, we estimated the comorbidity burden associated with HS, stratified by disease severity.MethodsA retrospective matched cohort design was used. Patients with HS were classified into two severity cohorts (milder and more severe) using an empirical algorithm based on treatments received. The comorbidity burden was compared between each HS cohort and their matched HS-free cohort, and between patients with milder vs. those with more severe forms of HS.ResultsSeveral physical and mental comorbidities were found to be more prevalent in both cohorts of patients with milder and more severe forms of HS than in their matched HS-free cohorts. The comorbidity burden also increased greatly as the disease progressed to more severe forms.ConclusionsThe results of this study highlight the complexity of the comorbidity burden of HS patients and the need for a multidisciplinary approach to optimize the management of HS and its numerous associated comorbidities.FundingAbbVie, Inc.Electronic supplementary materialThe online version of this article (10.1007/s13555-018-0264-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The Comorbidity Burden of Hidradenitis Suppurativa in the United States: A Claims Data Analysis

Kimball

Sundaram

Gauthier

et al. 2018

Dermatol Ther (Heidelb)

115

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“…According to the literature, CCC is associated with vaginal adenosis in DES-exposed women, while mucinous carcinoma and squamous cell carcinoma may arise in a context of chronic inflammation. [15,16] For the clinical treatment of vaginal adenosis, local resection is preferred. Immune response modifiers, such as imiquimod, can achieve ideal goals in the treatment of vaginal lesions, for example, complete response of vaginal intra-epithelial neoplasia in 57% to 86% of patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden

Han¹,

Jin²,

Li³

et al. 2018

Medicine

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In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20.0.Twenty women were histopathologically diagnosed as having vaginal adenosis (mean age, 37.9 ± 10.6 years). All patients denied utero exposure. The most common symptom was vaginal pain or abnormal bleeding. For all patients, the local vaginal lesions were surgically excised. Seven patients had complications with endometriosis. 15 patients lived without recurrence, and 1 patient underwent postoperative local recurrence after 81 months. Primary vaginal squamous cell carcinoma in another patient was confirmed to arise from adenosis; she survived with disease. The remaining 3 patients developed carcinoma of different types in varied periods of a disease-free state (5 months, 30 months, and 23 years, respectively); 1 patient died of progressive disease, and 2 patients survived with disease.Primary vaginal adenosis is a spontaneous lesion with a propensity for late canceration. Local lesion resection is the primary treatment.

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“…Another patient developed 3 different types of skin cancer, namey a basal cell carcinoma, a paucilesional Kaposi sarcoma and a melanoma, on his lymphedematous leg [6]. In view of this, we have hypothesized that the subclinical lymphedema associated with longstanding hidradenitis suppurativa may contribute to the development of squamous cell carcinoma or other skin cancers in the areas affected by the disease [8][9][10][11].…”

Section: Lymph Stasis Promotes Tumor Growthmentioning

confidence: 99%

Lymph stasis promotes tumor growth

Vita

Ruocco

2018

Journal of Dermatological Science

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were chosen. We found that the CXCL8 gene (IL-8) was the only gene whose induction by UVAwas completely abrogated with knockdown of GS1-600G8.5 (Fig. 2B). The secretion of the IL-8 protein was also significantly reduced (Fig. 2C). The observation that cells with knockdown of GS1-600G8.5 and IL-8 are still able to secrete some IL-8 upon UVA irradiation, albeit less than scramble-transfected cells, is probably due to activation and release of preformed IL-8 precursors from cellular storage vesicles. A role of GS1-600G8.5 in regulating IL-8 is consistent with the lack of effects on cell survival after UVA irradiation with knockdown of this lncRNA, because the survival of fibroblasts should not be affected by upregulation of IL-8.In endothelial and epithelial cells, including keratinocytes, IL-8 plays an important role in neutrophil chemotaxis [6]. To assess the impact of GS1-600G8.5 on IL-8 regulation in keratinocytes, we studied IL-8 expression with or without knockdown of GS1-600G8.5 after irradiation with UVA. Similar to fibroblasts, albeit not as prominent, knockdown of GS1-600G8.5 resulted in an abrogated IL-8 mRNA expression (Fig. 2D) and a reduced IL-8 secretion (Fig. 2E) also in keratinocytes.We conclude that GS1-600G8.5 is a crucial regulator of IL-8 in fibroblasts and keratinocytes, as knockdown of GS1-600G8.5 completely abrogates its UVA-induced upregulation at the mRNA level. There are several reports of IL-8 induction by ultraviolet radiation, including UVA in particular [7,8], but the clinical importance of the upregulation of IL-8 by UVA remains unclear. IL-8 is an important regulator of innate immunity and is a major driver of neutrophil chemotaxis. While UVA induced IL-8 may not be sufficient to cause neutrophil influx by itself, it may still be an important contributor when UVA exposure occurs in combinations with UVB, e.g. with natural sun exposure. Lee et al's report [9] that neutrophil influx is most prominent with solar simulated radiation, stronger than with UVB alone, is consistent with this concept.Several photodermatoses can be induced by UVA. Their inflammatory infiltrates often contain neutrophils (e.g. in polymorphous light eruption) [10] and the UVA-induced upregulation of IL-8 may be a critical step in the elicitation of these conditions. We therefore propose that inhibition of the lncRNA GS1-600G8.5, e.g. by RNA interference, as a strategy to prevent UVA-induced upregulation of IL-8, may be useful for the treatment of UVA-induced photodermatoses.

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Mucinous adenocarcinoma in association with hidradenitis suppurativa: a new example of isoscartopic response

Cited by 5 publications

References 4 publications

The Comorbidity Burden of Hidradenitis Suppurativa in the United States: A Claims Data Analysis

The Comorbidity Burden of Hidradenitis Suppurativa in the United States: A Claims Data Analysis

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden

Lymph stasis promotes tumor growth

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