Mucinous Prostate Cancer Shows Similar Prognosis to Typical Prostate Acinar Carcinoma: A Large Population-Based and Propensity Score-Matched Study

Abstract

Background: Mucinous prostate cancer (PCa) is an extremely rare form of prostate malignancy. To date, the limited knowledge of its biology and outcomes stems from mostly small, single institution experiences. We analyzed the Surveillance, Epidemiology, and End Results (SEER) database to explore the incidence and treatment of mucinous PCa together with its prognostic factors to gain relatively large and consolidated insights. Methods: Age-adjusted incidence (AAI) rates were evaluated over time. Propensity score matching (PSM) and Kaplan-Meier analyses were used to compare the prognosis between mucinous PCa and typical prostate acinar adenocarcinoma. We assessed cancer-specific survival (CSS) and overall survival (OS) after patient stratification according to summary stage and treatment choice. Cox hazards regression analysis was performed to determine independent predictors of CSS and OS. Results: The AAI in 2016 was 0.24 per million. Patients with mucinous PCa had similar CSS and OS to matched individuals with typical prostate acinar adenocarcinoma. In terms of treatment, 65.3% of mucinous PCa patients underwent surgery, and 23.9% received radiation therapy. Patients who underwent surgery had longer survival (CSS, p = 0.012; OS, p < 0.001), and patients who received radiation therapy had similar survival to those who did not receive radiation therapy (CSS, p = 0.794; OS, p = 0.097). A multivariate Cox analysis for CSS and OS showed that older age (CSS: HR: 4.982, p = 0.001; OS: HR: 4.258, p < 0.001) and distant stage (CSS: HR: 40.224, p < 0.001; OS: HR: 9.866, p < 0.001) were independent prognostic factors for mucinous PCa patients. Conclusions: Mucinous PCa has an extremely low AAI. Analysis of its outcomes indicates that it is not a more malignant tumor as previously suspected. Mucinous PCa shows a similar prognosis to typical prostate acinar carcinoma. Surgery was associated with prolonged survival. An older age at diagnosis and distant stage was associated with poor survival.

Repeated Recurrences of Mucinous Prostate Carcinoma With Signet Ring Cells in the Urinary Bladder After Robotic-assisted Laparoscopic Radical Prostatectomy: a Case Report and Literatures Review

“…of 73 cases mucinous PCa matched serum PSA, tumor volume, rate of extra-prostatic extension and 5-year biochemical recurrence rates, nally concluded similar prognosis between the two groups of tumors. Feng et al (12). found the same conclusion and indicated that patients did not receive radiation therapy had similar cancer-speci c mortality with radiation therapy patients, con rmed the experience that mucinous PCa showed poor response to radiotherapy reported by previous study (13).…”

“…In contrast, some studies showed that mucinous PCa didn't implicate poor prognosis than typical prostate acinar carcinoma (n = 60) (9). The latter were supported by several recent studies (2,(10)(11)(12). The study by Bronkema et al (10).…”

BZW1 promotes cell proliferation in prostate cancer by regulating TGF-β1/Smad pathway

“…Prostate cancer (PCa) is one of the most prevalent urological cancers in men worldwide [1][2][3]. The incidence of PCa is increased worldwide in recent years [4][5].…”

Clinicopathological Analysis of the ISUP Grade Group And Other Parameters in Prostate Cancer: Elucidation of Mutual Impact of the Various Parameters

“…Although the incidence rate of this tumor is lower in Japan than that in Western countries (the incidence rates in Japan, the United States, and the United Kingdom are 27.0, 98.2, and 73.2 per 100,000 population, respectively) ( 5 ), its incidence is rapidly increasing with the westernization of lifestyles ( 6 ). Most malignant prostatic neoplasms (~90%) are adenocarcinomas ( 7 – 9 ). In patients who are required to undergo radical prostatectomy, various parameters can be evaluated through preoperative clinical investigations and histopathological analyses of surgical specimens.…”