Muco-adhesive clarithromycin-loaded nanostructured lipid carriers for ocular delivery: Formulation, characterization, cytotoxicity and stability

Makoni, Pedzisai A.; Khamanga, Sandile M.; Walker, Roderick B.

doi:10.1016/j.jddst.2020.102171

Cited by 19 publications

(12 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EM-NLCs were prepared by the previously reported emulsification ultra-sonication method with slight modification [ 30 ]. The detailed composition of the formulations (EM-NLCs1—EM-NLCs20) is shown in Table 2 .…”

Section: Methodsmentioning

confidence: 99%

Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment

Zafar

Imam

Yasir

et al. 2022

Gels

View full text Add to dashboard Cite

In the present study, erythromycin (EM)-loaded nanostructured lipid carriers (NLCs) were prepared by the emulsification and ultra-sonication method. EM-NLCs were optimized by central composite design using the lipid (A), pluronic F127 (B) and sonication time (C) as independent variables. Their effects were evaluated on particle size (Y1) and entrapment efficiency (Y2). The optimized formulation (EM-NLCs-opt) showed a particle size of 169.6 ± 4.8 nm and entrapment efficiency of 81.7 ± 1.4%. EM-NLCs-opt further transformed into an in-situ gel system by using the carbopol 940 and chitosan blend as a gelling agent. The optimized EM-NLCs in situ gel (EM-NLCs-opt-IG4) showed quick gelation and were found to be stable for more than 24 h. EM-NLCs-opt-IG4 showed prolonged drug release compared to EM in situ gel. It also revealed significant high permeation (56.72%) and flux (1.51-fold) than EM in situ gel. The irritation and hydration study results depicted no damage to the goat cornea. HET-CAM results also confirmed its non-irritant potential (zero score). EM-NLCs-opt-IG4 was found to be isotonic and also showed significantly (p < 0.05) higher antimicrobial activity than EM in situ gel. The findings of the study concluded that NLCs laden in situ gel is an alternative delivery of erythromycin for the treatment of bacterial conjunctivitis.

show abstract

Section: Methodsmentioning

confidence: 99%

Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment

Zafar

Imam

Yasir

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

“…Nanostructured lipid carriers (NLC) have emerged as a promising second generation of lipid nanoparticles, the first one being SLN [54,55]. This new unstructured-matrix SLN is made up of a mixture of blended solid and liquid lipids as a core matrix, and an aqueous phase containing a surfactant or a mixture of surfactants [54,[56][57][58].…”

Section: Nanostructured Lipid Carriersmentioning

confidence: 99%

Application of Lipid-Based Nanocarriers for Antitubercular Drug Delivery: A Review

et al. 2021

Self Cite

View full text Add to dashboard Cite

The antimicrobial drugs currently used for the management of tuberculosis (TB) exhibit poor bioavailability that necessitates prolonged treatment regimens and high dosing frequency to achieve optimal therapeutic outcomes. In addition, these agents cause severe adverse effects, as well as having detrimental interactions with other drugs used in the treatment of comorbid conditions such as HIV/AIDS. The challenges associated with the current TB regimens contribute to low levels of patient adherence and, consequently, the development of multidrug-resistant TB strains. This has led to the urgent need to develop newer drug delivery systems to improve the treatment of TB. Targeted drug delivery systems provide higher drug concentrations at the infection site, thus leading to reduced incidences of adverse effects. Lipid-based nanocarriers have proven to be effective in improving the solubility and bioavailability of antimicrobials whilst decreasing the incidence of adverse effects through targeted delivery. The potential application of lipid-based carriers such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, nano and microemulsions, and self-emulsifying drug delivery systems for the treatment of TB is reviewed herein. The composition of the investigated lipid-based carriers, their characteristics, and their influence on bioavailability, toxicity, and sustained drug delivery are also discussed. Overall, lipid-based systems have shown great promise in anti-TB drug delivery applications. The summary of the reviewed data encourages future efforts to boost the translational development of lipid-based nanocarriers to improve TB therapy.

show abstract

“…In general the inclusion of polymers, lipids, and surfactants for the production of suitable carriers for medicinal and non-medicinal applications has been demonstrated and opportunities to produce technologies that exhibit advantages over conventional formulations including improved stability, enhanced and beneficial biodistribution profiles, altered drug release rates, lower immunotoxicity and with potential targeting of specific cells, exists [ 108 ]. Micro- and/or nano-encapsulation has been used to develop sustained/prolonged drug delivery technologies [ 30 , 109 , 110 ], minimise degradation in biological fluids [ 111 ], facilitate handling [ 112 ] reduce toxicity [ 109 , 113 , 114 , 115 ] and to improve the organoleptic properties [ 19 , 116 , 117 ] of products.…”

Section: Encapsulation and Evaluation Of Therapeutic Benefits Of Curmentioning

confidence: 99%

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

et al. 2021

Self Cite

View full text Add to dashboard Cite

There is a dearth of natural remedies available for the treatment of an increasing number of diseases facing mankind. Natural products may provide an opportunity to produce formulations and therapeutic solutions to address this shortage. Curcumin (CUR), diferuloylmethane; I,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione is the major pigment in turmeric powder which has been reported to exhibit a number of health benefits including, antibacterial, antiviral, anti-cancer, anti-inflammatory and anti-oxidant properties. In this review, the authors attempt to highlight the biological and pharmacological properties of CUR in addition to emphasizing aspects relating to the biosynthesis, encapsulation and therapeutic effects of the compound. The information contained in this review was generated by considering published information in which evidence of enhanced biological and pharmacological properties of nano-encapsulated CUR was reported. CUR has contributed to a significant improvement in melanoma, breast, lung, gastro-intestinal, and genito-urinary cancer therapy. We highlight the impact of nano-encapsulated CUR for efficient inhibition of cell proliferation, even at low concentrations compared to the free CUR when considering anti-proliferation. Furthermore nano-encapsulated CUR exhibited bioactive properties, exerted cytotoxic and anti-oxidant effects by acting on endogenous and cholinergic anti-oxidant systems. CUR was reported to block Hepatitis C virus (HCV) entry into hepatic cells, inhibit MRSA proliferation, enhance wound healing and reduce bacterial load. Nano-encapsulated CUR has also shown bioactive properties when acting on antioxidant systems (endogenous and cholinergic). Future research is necessary and must focus on investigation of encapsulated CUR nano-particles in different models of human pathology.

show abstract

Muco-adhesive clarithromycin-loaded nanostructured lipid carriers for ocular delivery: Formulation, characterization, cytotoxicity and stability

Cited by 19 publications

References 77 publications

Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment

Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment

Application of Lipid-Based Nanocarriers for Antitubercular Drug Delivery: A Review

Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin

Contact Info

Product

Resources

About