Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery

Shtenberg, Yarden; Goldfeder, Mor; Prinz, Hodaya; Shainsky, Janna; Ghantous, Yasmine; El-Naaj, Imad Abu; Schroeder, Avi; Bianco‐Peled, Havazelet

doi:10.1016/j.ijbiomac.2017.12.137

Cited by 105 publications

(53 citation statements)

References 47 publications

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“…This suggests that samples containing alginate as biopolymer or beads did not slip easily and provided some sort of oral coating properties due to the alginate itself or created a 'weeping' layer of water as a lubricant during tribological shearing (Gong & Osada, 2002), as discussed in the previous section. The oral coating property of alginates is in agreement with literature suggesting that alginate can create hydrogen bonds with human salivary mucins through carboxyl-hydroxyl interactions (Cook, Bull, Methven, Parker, & Khutoryanskiy, 2017;Shtenberg, et al, 2018).…”

Section: Thesupporting

confidence: 88%

On relating rheology and oral tribology to sensory properties in hydrogels

et al. 2019

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Section: Thesupporting

confidence: 88%

On relating rheology and oral tribology to sensory properties in hydrogels

et al. 2019

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“…11). In adherence studies, the retention of polymer on tongue tissue during a long time was 50% for the past and 80% for the cross-linked past verifying stronger adhesion of cross-linked past [100]. Anti-tuberculosis drugs were tested in mice treated with cation-induced calcium chloride alginate nanoparticles.…”

Section: Alginate Applicationsmentioning

confidence: 99%

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

et al. 2020

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Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb a large amount of water or biological fluids, which leads to their swelling while maintaining their 3D structure without dissolving (Zhu and Marchant, Expert Rev Med Devices 8:607-626, 2011). Among the numerous polymers which have been utilized for the preparation of the hydrogels, polysaccharides have gained more attention in the area of pharmaceutics; Sodium alginate is a non-toxic, biocompatible, and biodegradable polysaccharide with several unique physicochemical properties for which has used as delivery vehicles for drugs (Kumar Giri et al., Curr Drug Deliv 9:539-555, 2012). Owing to their high-water content and resembling the natural soft tissue, hydrogels were studied a lot as a scaffold. The formation of hydrogels can occur by interactions of the anionic alginates with multivalent inorganic cations through a typical ionotropic gelation method. However, those applications require the control of some properties such as mechanical stiffness, swelling, degradation, cell attachment, and binding or release of bioactive molecules by using the chemical or physical modifications of the alginate hydrogel. In the current review, an overview of alginate hydrogels and their properties will be presented as well as the methods of producing alginate hydrogels. In the next section of the present review paper, the application of the alginate hydrogels will be defined as drug delivery vehicles for chemotherapeutic agents. The recent advances in the application of the alginate-based hydrogels will be describe later as a wound dressing and bioink in 3D bioprinting.

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“…However, in this study improvement of the mucoadhesieve properties of CaCl 2 cross-linked ALG microparticles was observed. This fact can be explained by the presence of Ca 2+ ions, which interact with the negatively charged mucin [ 57 , 58 ]. An increase in the positive charge of the polymer leads to better interactions with sialic acid and other anionic groups present in mucin and the formation of additional bonds with the negatively charged membrane [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs

et al. 2018

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Alginate (ALG) cross-linking by CaCl2 is a promising strategy to obtain modified-release drug delivery systems with mucoadhesive properties. However, current technologies to produce CaCl2 cross-linked alginate microparticles possess major disadvantages, such as a poor encapsulation efficiency of water-soluble drugs and a difficulty in controlling the process. Hence, this study presents a novel method that streamlines microparticle production by spray drying; a rapid, continuous, reproducible, and scalable technique enabling obtainment of a product with low moisture content, high drug loading, and a high production yield. To model a freely water-soluble drug, metformin hydrochloride (MF) was selected. It was observed that MF was successfully encapsulated in alginate microparticles cross-linked by CaCl2 using a one-step drying process. Modification of ALG provided drug release prolongation—particles obtained from 2% ALG cross-linked by 0.1% CaCl2 with a prolonged MF rate of dissolution of up to 12 h. Cross-linking of the ALG microparticles structure by CaCl2 decreased the swelling ratio and improved the mucoadhesive properties which were evaluated using porcine stomach mucosa.

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Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery

Cited by 105 publications

References 47 publications

On relating rheology and oral tribology to sensory properties in hydrogels

On relating rheology and oral tribology to sensory properties in hydrogels

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs

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