Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold

Alopaeus, Julia Fredrika; Hellfritzsch, Marie; Gutowski, Tobias; Scherließ, Regina; Almeida, Andreia; Sarmento, Bruno; Škalko‐Basnet, Nataša; Tho, Ingunn

doi:10.1016/j.ejps.2019.105142

Cited by 61 publications

(35 citation statements)

References 43 publications

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“…Alopaeous et al also designed mucoadhesive buccal films as a mucin-retentive hydrogel scaffold. Their films were prepared with Soluplus, including other polymers with more hydrophilic and known mucoadhesive properties: hydroxypropyl methylcellulose Lycoat [ 13 ]. Their film, as in our case, was expected to have a longer residence time on the oral mucosa, but their objective was to achieve a fast release of the micelles to facilitate buccal absorption According to their release aims, authors performed disintegration tests but not a release assay as intended in our work.…”

Section: Resultsmentioning

confidence: 99%

“…At pre-determined time intervals (0.5, 1, 1.5, 2, and 5 min), the films were extracted from the solvent and weighted after solvent removal. The swelling index (SI t ) was calculated according to the following equation [ 13 ], based on the degree of fluid uptake, as reported by Nanda el at. [ 22 ]:…”

Section: Methodsmentioning

confidence: 99%

“…This novel formulation is inspired in the work of Alopaeous et al, who designed Soluplus-based films for buccal delivery of furosemide. The authors postulated that Soluplus present in the film will disperse and form micelles after application on a wet surface [ 13 ]. In the low volume of the tears, the Soluplus concentration is expected to be above the critical micellar concentration.…”

Section: Introductionmentioning

confidence: 99%

“…Here, the micelles containing the drug in a soluble form can produce a concentration gradient over the cornea ensuring passive diffusion over the barrier. The film suffers a transformation from a dry, solid, and stable formulation into an advanced ocular delivery system after contact with the tears [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Guillot

Petalas

Skondra

et al. 2021

Drug Deliv. and Transl. Res.

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Infections of the eye are among the leading causes of vision impairment and vision loss worldwide. The ability of a drug to access the anterior parts of the eye is negligible after systemic administration. Effective drug delivery to the eye is a major challenge due to the presence of protective mechanisms and physiological barriers that result in low ocular availability after topical application. The main purpose of this work was the improvement of the corneal and conjunctival permeation of the antibiotic Ciprofloxacin, a wide spectrum antibiotic used for the most common eye infection, using a self-dissolving polymeric film. Films were prepared by the solvent casting technique, using polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer (Soluplus), polyvynyl alcohol, and propylene glycol. Films were homogeneous in drug content and thickness, as demonstrated by adapting the Swiss Roll technique followed by microscopy observation. These films proved in vitro to control the release of the Ciprofloxacin. Ex vivo permeability studies using Franz diffusion cells and porcine cornea and sclera showed an effective permeability of the drug without inducing irritation of the tissues. Films swelled in contact with artificial tears forming an in situ gel over 20 min, which will improve drug contact and reduce the need of multiple dosing. The antibiotic activity was also tested in vitro in five types of bacterial cultures, assuring the pharmacological efficacy of the films. The developed films are a promising drug delivery system to topically treat or prevent ocular infections. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Guillot

Petalas

Skondra

et al. 2021

Drug Deliv. and Transl. Res.

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“…It was claimed that films with intermediate strength and certain level of flexibility were needed to improve and facilitate interaction with the mucosa. [ 25 ] As summarized in Table 2 , it was found that the tensile strength of the films was affected by the type of polymer. The tensile strengths were in the respective order of HPMC >> SCMC > NGRS > 15m‐MGRS ≈ chitosan ≈ 45m‐MGRS.…”

Section: Resultsmentioning

confidence: 99%

Films Fabricated with Native and Ball‐Milled Modified Glutinous Rice Starch: Physicochemical and Mucoadhesive Properties

2020

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This study aims to investigate the physicochemical and mucoadhesive properties of films made of glutinous rice starch (GRS), native (NGRS), and ball‐milled modified GRS (MGRS), in comparison with the reference mucoadhesive polymers. By using the solvent casting technique with glycerol (30% w/w of starch mass) as a plasticizer, all GRS films exhibit satisfactory and comparable thickness and weight uniformity, surface pH, and moisture content. ATR‐FTIR indicates that the hydrogen bonds are formed between GRS and glycerol. The absence of crystalline structure of GRS in glycerol plasticized films is confirmed using ATR‐FTIR and XRD. The films made of NGRS and MGRS have similar swelling behavior (751 ± 75 to 1002 ± 104%), whereas those made of longer milling time MGRS demonstrate higher erosion (27.1 ± 4.2%) (p < 0.05). MGRS films exhibit greater flexibility with lower tensile strength (9.6 ± 1.7 to 9.8 ± 1.0 MPa) but higher elongation (162.5 ± 6.5 to 165.7 ± 2.5%) compared to native systems (13.7 ± 0.5 MPa and 128.1 ± 5.0%, respectively) (p < 0.05). The MGRS films show comparable mucoadhesiveness expressed as detachment force and work of adhesion to those of sodium carboxymethylcellulose, but higher than those of NGRS, hydroxypropyl methylcellulose, and chitosan (p < 0.05). This study reveals the potential exploitation of GRS as a mucoadhesive film former for pharmaceutical application.

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Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

Bayer

2022

Adv Materials Inter

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Mucoadhesion is an extremely important field of adhesion science and the comprehensive understanding and modulation of mucoadhesion can lead to lifesaving materials and technologies. For instance, deadly cases of COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral adhesion and overproduction of mucus, which obstructs the airways. Mucin is the key polymeric compound that is known as a family of high molecular weight, heavily glycosylated proteins in epithelial tissues. Mucoadhesion can occur in many different ways such as receptor specific and charge interactions, covalent or noncovalent bonds. New mucin‐mimic polymers that replicate its beneficial traits can prevent biofilm formation and biofouling not only in biotechnology but also in membrane technologies. This review addresses the latest understandings related to mucin's role in wet adhesion considering different physiological conditions and shows how this translates into interfacial polymer adhesion. Advances in mucoadhesion measurement techniques including the rheological aspects of polymer–mucin adhesive interactions are presented. Specific mucoadhesive systems are discussed such as hydrogel mucoadhesion, catechol/dopamine functionalization, and polymeric nanoparticles. This overview may expand the current understanding of mucoadhesion between soft materials but also contributes to elastocapillary phenomena in soft materials design and applications such as new membranes, drugs, pharmaceutical devices, and lubricated surfaces.

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Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold

Cited by 61 publications

References 43 publications

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Films Fabricated with Native and Ball‐Milled Modified Glutinous Rice Starch: Physicochemical and Mucoadhesive Properties

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

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