Mucoadhesive buccal films containing phospholipid-bile salts-mixed micelles as an effective carrier for Cucurbitacin B delivery

Lv, Qingyuan; Shen, Chengying; Li, Xianyi; Shen, Biao; Cao, Yu; Xu, Peng; Xu, He; Han, Jihong; Yuan, Hailong

doi:10.3109/10717544.2013.876459

Cited by 37 publications

(21 citation statements)

References 30 publications

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“…A variety of polymeric local drug delivery systems (Figure ) have been developed and evaluated for their potential against OSCC . The delivery of chemopreventive agents directly into the affected site of the mouth provides multiple therapeutic advantages .…”

Section: Introductionmentioning

confidence: 99%

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Desai

2017

J Biomed Mater Res

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Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery. A variety of polymeric systems-such as gels, tablets, films, patches, injectable systems (e.g., millicylindrical implants, microparticles, and in situ-forming depots), and nanosized carriers (e.g., polymeric nanoparticles, nanofibers, polymer-drug conjugates, polymeric micelles, nanoliposomes, nanoemulsions, and polymersomes)-have been developed and evaluated for the local delivery of natural and synthetic chemopreventive agents. The findings of in vitro, ex vivo, and in vivo studies and the positive outcome of clinical trials demonstrate that intraoral site-specific drug delivery is an attractive, highly effective and patient-friendly strategy for the management of oral cancer. Intraoral site-specific drug delivery provides unique therapeutic advantages when compared to systemic chemotherapy. Moreover, intraoral drug delivery systems are self-administrable and can be removed when needed, increasing patient compliance. This article covers important aspects and advances related to the design, development, and efficacy of polymeric systems for intraoral site-specific drug delivery. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1383-1413, 2018.

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Section: Introductionmentioning

confidence: 99%

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Desai

2017

J Biomed Mater Res

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“…This alternative site offers rapid and direct delivery into the systemic circulation, easy accessibility, higher patient compliance, besides being capable of enhancing bioavailability (Palem et al, 2011). Among the various buccal dosage forms, buccal film is the most advanced and highly preferred drug delivery system on account of easy adherence to buccal mucosa, better adaptation to the mucosal surface and prolonged retention (Castán et al, 2014;Lv et al, 2014). It was also reported that the buccal delivery of selegiline is likely to enhance the absorption as well as reduce the formation of metabolites when compared to conventional therapy (Nyholm, 2006).…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of buccal films impregnated with selegiline-loaded nanospheres

Al‐Dhubiab

Nair

Kumria³

et al. 2014

Drug Delivery

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Poor peroral therapeutic efficiency of selegiline is primarily due to the extensive hepatic metabolism and hence the need for an alternative route of administration. The present study is based on evaluation of a buccal film which is impregnated with selegiline nanospheres to enhance the systemic bioavailability. Selegiline-loaded nanospheres prepared using poly(lactide-co-glycolide) was embedded into buccal films (F 1 -F 4 ) with varying polymer composition [hydroxypropyl methylcellulose and eudragit]. The developed films were evaluated for their physicomechanical properties, hydration, mucoadhesive strength, in vitro drug release and ex vivo permeation in order to identify the ideal system suitable for further development. In vivo studies were carried out on rabbits to assess the comparative pharmacokinetics profile of the selected buccal film with oral solution. Preliminary studies indicated that the prepared films exhibited excellent physical properties, adequate mucoadhesive strength and moderate hydration. In vitro drug release data of the buccal films (F 1 , F 2 and F 3 ) showed distinct profiles. Permeation studies indicated higher steady-state flux from film F 3 (p50.0001) when compared to film F 2 . In-vivo results of film (F 3 ) demonstrated significant increase in absorption (p50.0001), C max ($1.6-fold), T max , AUC 0-a ($3-fold, p50.0001) and improved bioavailability, when compared to control. This study concludes that the buccal delivery of selegiline using the developed buccal film (F 3 ) would be a promising alternative approach for the treatment of Parkinson's disease.

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“…10,11 In the optimized formulation, the total concentration of PL/SDC was 54 mg/mL and the mass concentration ratio was 1:0.8. Briefly, PL and SDC were dissolved by anhydrous ethanol in a round-bottom flask.…”

Section: Preparation and Characterization Of Pl-sdc-mms Preparationmentioning

confidence: 99%

“…10,11 Cu B, the major compound in cucurbitacin, has a broad range of biological activity, including anti-inflammatory, hepatocurative, and hepatoprotective effects. [12][13][14] GL is one of the main components extracted from Glycyrrhiza glabra L. and it possesses a variety of pharmacological effects, including anti-inflammatory, antiviral, and antioxidative activity.…”

Section: Et Almentioning

confidence: 99%

“…Different formulations were administered orally to fasted male Beagle dogs (n=5, body weight 10-11 kg) in a crossover study at a dose of 1 mg/kg for Cu B and 100 mg/kg for GL. 10,11 The washout period between dosing with each formulation was 7 days. A blood sample of approximately 2 mL was collected from each animal at 0 (pre-dose), and 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, 12 and 24 hours post-dose.…”

Section: Bioavailability Studymentioning

confidence: 99%

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Application of spray granulation for conversion of mixed phospholipid-bile salt micelles to dry powder form: influence of drug hydrophobicity on nanoparticle reagglomeration

Lv¹,

Shen³

et al. 2014

IJN

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The aim of this study was to investigate the feasibility of using spray granulation as a drying method to convert phospholipid (PL)-sodium deoxycholate (SDC)-mixed micelles (MMs) containing a water-insoluble drug to a solid dosage form and to evaluate how drugs with significantly different physicochemical properties affect the spray granulation process and subsequent in vitro and in vivo processes. Cucurbitacin B (Cu B) and glycyrrhizin (GL) were used as the model drugs. After spray granulation, the dried Cu B-PL/SDC-MM powder was completely redispersible within 15 minutes in vitro. Meanwhile, the area under the curve during 24 hours (AUC 0–24 ) and peak serum concentration from the dried powder were significantly ( P <0.05) lower than the values from Cu B-PL/SDC-MMs in vivo. However, a better result was obtained for GL, ie, the drug was redispersed completely within 5 minutes in vitro. Further, absorption from the dried GL-PL/SDC-MM powder was increased to the same level as that for GL-PL/SDC-MMs in vivo compared with the control group. The difference in these results can be found in Cu B and GL. Cu B nanoparticles reagglomerated when released, resulting in slower redispersibility and less absorption compared with the original PL-SDC-MMs. However, no agglomeration or delay was observed for GL. A possible explanation is the difference in surface hydrophobicity between Cu B and GL. The results of this study not only show that spray granulation is an effective drying technique that can complement spray-drying and freeze-drying, but also confirm that the physicochemical properties of a drug have a significant influence on the in vitro and in vivo performance of the dried powder obtained after spray granulation.

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Mucoadhesive buccal films containing phospholipid-bile salts-mixed micelles as an effective carrier for Cucurbitacin B delivery

Cited by 37 publications

References 30 publications

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Development and evaluation of buccal films impregnated with selegiline-loaded nanospheres

Application of spray granulation for conversion of mixed phospholipid-bile salt micelles to dry powder form: influence of drug hydrophobicity on nanoparticle reagglomeration

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