Mucoadhesive buccal patches based on interpolymer complexes of chitosan–pectin for delivery of carvedilol

Abstract

The study was designed to develop bioadhesive patches of carvedilol hydrochloride using chitosan (CH) and pectin (PE) interpolymer complexes and to systematically evaluate their in vitro and in vivo performances. Mucoadhesive buccal patches of carvedilol were prepared using solvent casting method. The physicochemical interaction between CH and PE was investigated by FTIR and DSC studies. The patches were evaluated for their physical characteristics like mass variation, content uniformity, folding endurance, ex vivo mucoadhesion strength, ex vivo mucoadhesion time, surface pH, in vitro drug release, in situ release study, and in vivo bioavailability study. The swelling index of the patches was found to be proportional to the PE concentration. The surface pH of all the formulated bioadhesive patches was found to lie between 6.2 and 7.2. The optimized bioadhesive patch (C1, CH:PE 20:80) showed bioadhesive strength of 22.10 ± 0.20 g, in vitro release of 98.73% and ex vivo mucoadhesion time of 451 min with in a period of 8 h. The optimized patch demonstrated good in vitro and in vivo results. The buccal delivery of carvedilol in rabbits showed a significant improvement in bioavailability of carvedilol from patches when compared to oral route.

Controlled release effervescent buccal discs of buspirone hydrochloride:in vitroandin vivoevaluation studies

“…Variety of dosage forms like tablets (Boyapally et al, 2010, Kanjanabat & Pongjanyakul, 2011, discs (Yehia et al, 2008;Jaipal et al, 2013), patches (Abu-Huwaij et al, 2011;Kaur & Kaur, 2012;Govindasamy et al, 2013) and gels (Das et al, 2012;Bueno et al, 2013) have been reported in the literature for buccal delivery of drugs. Buccal discs are flat, thin solid unit non-flexible compacts; and are similar to buccal tablets.…”

Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits

“…3a). This figure also shows that the maximum swelling percentage (182.7%±8.1) of PC tablets was achieved after 7 h due to gel formation, uncoiling of the structure of PC molecules, and the formation of hydrogen bonds with water molecules (59). The swelling of PC tablets was significantly (p < 0.05) lower than SCMC or CP.…”

Formulation and Evaluation of Buccoadhesive Patch Containing Antihypertensive Drug

“…Swelling study [14,15] Buccal patches were weighed individually (W 1 ) and placed separately in 2% agar gel plates with the core facing the gel surface and incubated at 37 ± 1°C. At regular intervals (30, 60…300 min) the patches were removed from Petri dishes and excess water removed The patches were tested for the content uniformity.…”

“…Just before the experiment, it was thawed at room temperature and checked for any damage. [15,22,23] The in vitro drug release studies were conducted by using Franz diffusion cells and were performed in phosphate buffer (pH 7.4). The volume of buffer in the receiver compartment was 18 ml.…”