Mucoadhesive <i>in situ</i> gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and <i>in vitro/in vivo</i> evaluation

Rençber, Seda; Karavana, Sinem Yaprak; Şenyiğit, Zeynep Ay; Eraç, Bayrı; Limoncu, Mine Hoşgör; Baloğlu, Esra

doi:10.3109/10837450.2016.1163385

Cited by 78 publications

(60 citation statements)

References 53 publications

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“…Storage modulus (G') and loss modulus (G'') of the formulations were determined as previously described. [12][13][14][15] In each case, the rheological properties of the formulations were replicated three times.…”

Section: Rheological Studies Of the Gel Formulationsmentioning

confidence: 99%

“…Compressibility is the work required to deform the product during the first compression of the probe and the first area under the curve (AUC) defines compressibility. [12][13][14][15][16][17][18] Adhesiveness is the work necessary to overcome the attractive forces between the surface of the sample and the surface of the probe. The second AUC defines adhesiveness.…”

Section: Mechanical Properties Of Gel Formulationsmentioning

confidence: 99%

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Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Rençber¹,

Cheaburu-Yılmaz²,

Köse³

et al. 2019

Cellulose Chem. Technol.

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Interpolymeric complexes (IPCs) have the advantage of combined properties of their constituent polymers. They are easy to prepare under mild conditions and do not require high processing costs. The interpolymeric complexes of alginate, chitosan and Nystatin, as antifungal drug systems, represent an alternative for mucosal illness treatment. The composition of the two polymers is a key parameter in obtaining the desired properties for pharmaceutical formulations. IPCs of sodium alginate (SA) and chitosan (CS) were prepared via solution mixing method with various compositions, followed by coacervation in 2-propanol. The outcome obtained from rheological measurements was that the complex SA/CS 60/40 (v/v %) fulfilled the requirements of a semi-solid formulation, e.g. pseudoplasticity. Nystatin showed very good compatibility with the polymeric system. The drug loaded gels showed better rheological, textural and mechanical properties (e.g. pseudoelasticity, spreadability, surface adhesion etc.). The final gel formulations showed no cytotoxic effects in the cell culture assay.

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Section: Rheological Studies Of the Gel Formulationsmentioning

confidence: 99%

Section: Mechanical Properties Of Gel Formulationsmentioning

confidence: 99%

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Rençber¹,

Cheaburu-Yılmaz²,

Köse³

et al. 2019

Cellulose Chem. Technol.

Self Cite

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“…Commercial foam and gel are the commonly used dosage forms for the treatment of vaginal infection, but suffers from drug leakage and incomplete antimicrobial effects (Johal et al, 2016;Rencber et al, 2017). For foam, the drug retention was limited due to the removal of drug carrier by vaginal secretion and self-cleaning.…”

Section: Discussionmentioning

confidence: 99%

Expansible thermal gelling foam aerosol for vaginal drug delivery

Mei

Chen

et al. 2017

Drug Delivery

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Vaginal delivery of antimicrobial drugs is the most effective method for the local treatment of the vaginal infections. However, current vaginal drug delivery systems (VDDS), including gel, lotion, aerosol and cream, are suffering from low penetration in the deep vaginal rugae and easy elimination by self-cleaning of vaginal canal. To address these issues, a foam aerosol based on the thermal transformation was designed to improve penetration efficiency and achieve the extended retention. The expansible thermal gelling foam aerosol (ETGFA) consisting of thermal sensitive matrix, silver nanoparticle, adhesive agent and propellant, was optimized by evaluations of precursor viscosity, foam expansion, thermal gelation, gel adhesiveness, antimicrobial effects and tissue irritation. The ETGFA would penetrate to the deep vaginal rugae to cover the infectious sites by foam expansion. Drug leakage was intended to be avoided by the thermal gelation at physiological temperature before foam collapse. The gel could be retained in the vaginal canal for extended time due to its superior adhesiveness when compared to the commercial gel Asimi V R . The ETGFA provided extended drug release for over 4 h and maintained effective drug concentrations at the infectious sites. The ETGFA containing silver nanoparticles showed dose-dependent antimicrobial effects on the vaginal floras and irritation reduction to the vaginal tissues. The results demonstrated that the ETGFA could overcome the limitations of conventional dosage forms, including poor drug penetration, carrier retention and patient compliance and satisfied the requirements for vaginal drug delivery. ARTICLE HISTORY

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“…Treatment of vaginal candidiasis using clotrimazole in situ gel formed with mixture of poloxamer 407 and 188, also HPMC K100M or E50 is known to produce gel with good retention properties, which is the remaining of gel formulations remains in the vaginal mucose even after 24 h of application [11].…”

Section: Vaginalmentioning

confidence: 99%

Application and Characterization of in Situ Gel

et al. 2018

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Applications of in situ gel have been used for a variety of drug delivery routes, such as oral, ocular, rectal, vaginal and injection. Characterization of in situ gel was determined to ensure that the prepared preparation met the standard and it safe. This review describes every aspects of this novel application and characterization of in situ gel preparations, which present the readers an exhaustive detail and might contribute to research and development. In the chemical evaluation in situ gel determined the diffusion of the active substance of a compound by measuring its concentration. In physical evaluation of isotonic calculated by osmotic pressure, drug release was determined by melting point of the substance polymer, gel strength as measured by rheometer, homogenecity test determined by under the light, and stability test with environmental conditions setting. In microbiology evaluation determine if the preparations was contaminated or not, also be effective and safe. Ocular irritation studies-Draize Test us an animal mice or rabbit and determination of visual appearance, clarity, and pH is required. In situ gels offer the primary requirement of a successful controlled release product that is increasing patient compliance.

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Mucoadhesive in situ gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and in vitro/in vivo evaluation

Cited by 78 publications

References 53 publications

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Expansible thermal gelling foam aerosol for vaginal drug delivery

Application and Characterization of in Situ Gel

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