Mucoadhesivein situnasal gelling drug delivery systems for modulated drug delivery

Abstract

The challenges of drug delivery through nose has led to development of in situ nasal gelling systems using a myriad of polymers to deliver the drugs, proteins, amino acids, hormones, vaccines and plasmid DNA for the local, systemic and central nervous system effects. Though a range of preclinical reports are available, clinical intricacies need to be critically worked out.

Introduction

“…led to an extremely diversified literature on nasal delivery, and the number of publications is so wide that it is almost impossible to summarize the research that has been carried out on this topic. Therefore, it seemed appropriate to preliminarily report some recent review articles on this complex subject [130,133,136,139,147]. Anyhow, some significant results obtained in the last decade will be reported here.…”

Optimization of combinational intranasal drug delivery system for the management of migraine by using statistical design

“…To overcome these constrains, thermoreversible in-situ 77 mucoadhesive intranasal (TMIS) was formulated which gels at nasal 78 mucosal temperature and contains a bioadhesive polymer that 79 lengthens the residence time and thus the bioavailability of the 80 combinational drugs. Several attempts have been made to deliver 81 triptans (Majithiya et al, 2006;Godbole et al, 2014;Kempwade 82 and Taranalli, xxxx; Singh et al, 2013) by formulating a TMIS gel 83 using pluronic (Majithiya et al, 2006) and poloxamers (Zaki et al, 84 2007;Pisal et al, 2004 (Bromberg and Ron, 1998) Pluronic gel was prepared using cold technique described by 129 Schmolka IR (Schmolka, 1972 Pure xyloglucan was extracted from tamarind kernel powder 142 (TKP) using method described by Rao et al (1973). A known 143 amount of TKP was dissolved in 200 mL of cold distilled water to 144 prepare slurry and added slowly to 800 mL boiling water with con-145 tinuous stirring and kept overnight.…”

Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets

“…Recent researches focused on ionic cross-linkage (13), change in pH (13,14), or change in temperature (15,16).…”