Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride

Fefelova, N. A.; Nurkeeva, Zauresh S.; Mun, Grigoriy A.; Khutoryanskiy, Vitaliy V.

doi:10.1016/j.ijpharm.2007.02.019

Cited by 78 publications

(65 citation statements)

References 20 publications

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“…A number of reports were published demonstrating that native mucins, freshly isolated from animals, exhibit some biophysical properties which are partially lost upon their purification and storage. [60] However, the majority of studies evaluating mucoadhesive interactions have reported the use of commercially-available lyophilized porcine gastric mucin [51,57,58,[61][62][63][64] and bovine submaxillary gland mucin. [17,[65][66][67] Although, these products may differ from the native mucins they often show less batch-to-batch variability and give more reproducible results.…”

Section: Methods To Study Mucoadhesive Interactionsmentioning

confidence: 99%

“…The negative charge of mucin particles decreases upon acidification and approaches electroneutrality at around pH ¼ 2.0. [63] Rossi et al [57] , Fefelova et al [51] , Sogias et al [63] and Thongborisute and Takeuchi [68] have used a turbidimetric technique as a simple and reliable method to study the interactions between aqueous mucin dispersions and polycations such as chitosan and cationic methacrylate polymers. They found that formation of mucin/polymer complexes is accompanied by an increase in solution turbidity due to the aggregation of mucin particles caused by polymer adsorption at their surfaces and bridging effects ( Figure 8).…”

Section: Methods To Study Mucoadhesive Interactionsmentioning

confidence: 99%

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Advances in Mucoadhesion and Mucoadhesive Polymers

Khutoryanskiy

2010

Macromolecular Bioscience

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Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non-ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate mucoadhesive properties of various dosage forms and discusses the main classes of mucoadhesives.

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Section: Methods To Study Mucoadhesive Interactionsmentioning

confidence: 99%

Section: Methods To Study Mucoadhesive Interactionsmentioning

confidence: 99%

Advances in Mucoadhesion and Mucoadhesive Polymers

Khutoryanskiy

2010

Macromolecular Bioscience

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529

421

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“…PAA and Na CMC possess excellent mucoadhesive characteristics due to the formation of strong hydrogen bonding interactions with mucin [34]. Among the cationic polymer systems, chitosan is the most extensively investigated within the current scientific literature [35]. Chitosan is a cationic polysaccharide, produced by the deacetylation of chitin, the most abundant polysaccharide other than cellulose.…”

Section: Selected Polymers For Oro-soft Palate Mucoadhesive Systemsmentioning

confidence: 99%

A Smart Oro-Soft Palate Mucosal Drug Delivery: Credentials and Future Trends

Shankar

Madhav

2015

Marmara Pharm J

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Over the last few decades pharmaceutical scientists throughout the world are trying to explore transdermal and transmucosal routes as an alternative to injections. The main impediment for the oral delivery of the drugs as potential therapeutic agents is their extensive pre-systemic metabolism, instability in acidic environment associated with inadequate and erratic oral absorption. The parenteral route is the only established route that overcomes all the drawbacks related with the orally inefficient drugs. However the parenteral formulations are expensive, need frequent administration, with less patient compliance and other harmful effects. Since ancient times oral transmucosal drug delivery has received intensive interest for the systemic delivery of drugs proved to have better systemic bioavailability achieved by oromucosal route. Oral mucosal drug delivery provides an alternative method of systemic drug delivery which offers many advantages for both parenterals and oral methods. The oral mucosa is highly vascularised, hence drugs which are absorbed through the oral mucosa directly enter into the systemic circulation, bypassing the enzymes present in the gastrointestinal tract and first-pass metabolism in the liver. The various transmucosal sites available are sublingual and buccal, but also the soft-palatal mucosa was found to be the most convenient and easily accessible novel site for the delivery of therapeutic agents for systemic delivery as retentive dosage forms. It has adequate blood supply, rapid cellular recovery time after exposure to stress, flexible, smooth surface, devoid of mechanical irritation, local discomfort and non-invasive route. Recently soft palate route explore more attention towards the scientist as an alternative to buccal route for administering drugs using mucoadhesive drug delivery dosage forms. This review focuses the more recent advances in novel soft palate route and formulation strategies to design dosage forms to administer drug through this novel soft palate route.

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“…These include alginates, carrageenan, poly(-acrylic acid) (PAA) and its weakly cross-linked derivatives and sodium carboxymethylcellulose (NaCMC). PAA and NaCMC possess excellent mucoadhesive characteristics due to the formation of strong hydrogen bonding interactions with mucin 23 .…”

Section: Anionic Polymersmentioning

confidence: 99%