Mucoadhesive Microspheres: A Review

Kumari, N. Lalitha; Aggarwal, Geeta; Harikumar, S L

doi:10.22270/jddt.v4i5.953

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…A drug under consideration is added into a dilute polymeric solution of methylene chloride. This mixture is added into a bath or petroleum ether, and a strong nonsolvent resuls in the 1:100 ratio without any stirring …”

Section: Methods Of Preparationmentioning

confidence: 99%

“…Microspheres have many applications, and some of which are as follows: ▪Microspheres are used to prepare controlled and sustained release dosage forms. ▪Enteric‐coated dosage forms can be prepared using microspheres. As a result, the medication selectively absorbs in intestine instead of stomach. ▪Drugs can be protected from environmental hazards including humidity, light, oxygen, or heat.…”

Section: Applicationsmentioning

confidence: 99%

“…Mucoadhesive microspheres have various advantages, some of them are ▪reliable and specific method for drug delivery maintaining desired drug concentration at a target site, ▪ability for controlled drug release throughout the particle mix by use of solid biodegradable microspheres, ▪targeting of drugs for prolonged disease and anticancer drugs on tumor sites, ▪potential action on the pathogens residing intracellularly though macrophage uptake of microspheres, and ▪regional blood flow studies in tissues and organs, especially chronic studies, can be done by fluorescence using 10–15 μm diameter microspheres containing fluorescent dyes. On the other hand, these systems also present some shortcomings. Some of the disadvantages are as follows: ▪There is a possibility of modification of the released drug. ▪The release rate may be a function of food, gut transit rate, mucin turnover rate, etc. ▪The release rate may depend on an individual person's characteristics. ▪Potential toxicity caused by integrity loss or variations in drug release pattern. ▪Dosage forms are unable to be chewed or crushed. …”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review

Zaman

Sajid

Rehman

2015

Adv. Polym. Technol.

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ABSTRACT:Mucoadhesive microspheres are one of the most promising novel techniques for drug delivery. Mucoadhesive systems offer a sustained drug release method, thus enhancing drug absorption in a site-specific manner. Microspheres have very small sizes and provide efficient carrier capacities. Mucoadhesive systems therefore play a vital role in drug delivery systems. Mucoadhesion is a two-step procedure, and its mechanism can be explained by combining theories of wetting, mechanical interlocking, electronic transfer, adsorption, fracture, and diffusion interpenetration, as deemed suitable. Mucoadhesive microspheres offer added advantages of reliability, safety, specificity, prolonged action, delayed release, and enhanced activity along with a very few disadvantages. These systems can be prepared by emulsion cross-linking, single emulsion, ionotropic gelation, phase inversion, spray drying, solvent removal, and hot melt methods. The resulting microspheres are characterized using a number of parameters such as size, surface, efficiencies, and release studies. Mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal, and vaginal applications with systemic as well as local effects. They give a chance to deliver the drugs which were not possible to administer by oral route. This review article gives an overview of mucoadhesive microspheres, their pros and cons, preparation methods, characterization, application, and recent developments. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 2015, 0, 21550; View this article online at wileyonlinelibrary.com.

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Section: Methods Of Preparationmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal Mucosa: The Target Site of Mucoadhesive Microspheres, A Review

Zaman

Sajid

Rehman

2015

Adv. Polym. Technol.

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“…These microspheres can be loaded with a variety of drugs, including small molecules, peptides, proteins, and nucleic acids, and can be formulated to release the drug in a controlled manner over an extended period of time. The mucoadhesive properties of the microspheres ensure prolonged contact with the mucosal surfaces, facilitating enhanced drug absorption and bioavailability 1,2,3 .…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Ketoprofen Loaded Mucoadhesive Microspheres

Pattanayak,

Kanthal,

Afnan

et al. 2024

J. Drug Delivery Ther.

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The aim of the present study was to prepare and evaluate Ketoprofen loaded microspheres fabricated with sodium alginate and Carbopol 934 by ion gelation method which enhances the drug residence time into the stomach by adhering to the mucus layer of and control the rate of drug release for longer period of time. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used for its analgesic, anti-inflammatory, and antipyretic (fever-reducing) properties. It belongs to the propionic acid class of NSAIDs and is available in various formulations, including oral tablets, capsules, topical gels, creams, and as an injectable solution. In present study ketoprofen incorporates in mucoadhesive drug delivery system for utilizing its controlled drug delivery up to 12 hrs. In present study prepared microspheres were evaluated for- particle size, entrapment efficiency, percentage yield, morphology, mucoadhesive property, in-vitro drug release property. Keywords: Mucoadhesive microspheres, NSAID, ion gelation method, ketoprofen

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