Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: preparation and in vitro characterization

Hasçicek, Canan; Gönül, Nurşin; Erk, Nevin

doi:10.1016/s0014-827x(02)00004-6

Cited by 71 publications

(47 citation statements)

References 22 publications

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“…The mucoadhesive formulations, administered by rectal (Choi, Oh, and Kim 1998;Ryu et al 1999;Yahagi, Onishi, and Machida 1999), vaginal (Lee and Chien 1996;Valenta et al 2001;Ceschel et al 2001a;Cevher, Sahin, and Araman 2002;Chang et al 2002;Chien and Lee 2002;El-Kamel et al 2002;Maggi et al 2000), oral (Takeuchi et al 2003), buccal (Shojaei, Zhou, and Li 1998;Alur et al 1999;Han et al 1999;Choi and Kim 2000;Shin, Bum, and Choi 2000;Ceschel, Maffei, and Lombardi 2001b;Perioli et al 2004), nasal (Ugwoke et al 1999;Yahagi et al 2000;Pavelic, SkalkoBasnet, and Schubert, 2001;Hasçiçek, Gönül, and Erk 2003;58 E. CEVHER ET AL. Sales et al 2003), and ocular (Yun et al 1999;Ceulemans et al 2001) routes, have been prepared by using polymers showing appropriate adhesiveness.…”

Section: Human Papilloma Virus (Hpv) Causes Infection In the Genital mentioning

confidence: 99%

Evaluation of Mechanical and Mucoadhesive Properties of Clomiphene Citrate Gel Formulations Containing Carbomers and Their Thiolated Derivatives

Cevher

Taha²,

Orlu

et al. 2008

Drug Delivery

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Section: Human Papilloma Virus (Hpv) Causes Infection In the Genital mentioning

confidence: 99%

Evaluation of Mechanical and Mucoadhesive Properties of Clomiphene Citrate Gel Formulations Containing Carbomers and Their Thiolated Derivatives

Cevher

Taha²,

Orlu

et al. 2008

Drug Delivery

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“…18. The melting point is 275.9°F (135.5ºC), the water content (Karl Fischer method) is 1.33% (w/w) and the solubility in water is 100mg/ml.…”

Section: Introductionmentioning

confidence: 99%

Novel, Sustained-Release, Dry-Powder Inhalable Formulation for Montelukast Sodium

Sathishkumar¹,

Kumaresan²

2017

Int. Res. J. Pharm.

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The objective of this research is to improve therapy for asthma patients by developing a drug delivery platform for inhalation of a sustained-release, dry-powder formulation for Montelukast Sodium (MS). Montelukast Sodium microparticles were prepared with solvent evaporation process. The microspheres were then blended with an inhalable lactose additive (Lactohale), which acts as a carrier molecule in the formulation. Total four formulations A, B, C and D were prepared with 1:1, 1:2, 1:3, 1:4 ratio of MS:Eudragit RS100. The developed formulations were studied for physicochemical properties, in vitro drug relase and Anderson cascade impaction studies. Based on dissolution presentation, the 1:1 ratio of MS:Eudragit RS100 produces in vitro release 93.71% at 12 h and having particle size of microparticles (D0.5 µm) 4.92±0.7 and the pulmonary deposition of dry powder 38.4 ± 3.53 (respiratory fraction in percentage).

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“…2,3 To avoid the use of organic solvent, alternative techniques have been reported such as ionic gelation, coacervation precipitation, and spray-drying. [4][5][6] Spray-drying technique, a one-step process, offers the advantages of good production yield and reproducibility. Although there were numerous reports on spray-dried mucoadhesive microspheres, they were mostly less than 5 μm in diameter.…”

Section: Introductionmentioning

confidence: 99%

Spray-dried mucoadhesive microspheres: Preparation and transport through nasal cell monolayer

et al. 2006

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The purpose of this research was to prepare spray-dried mucoadhesive microspheres for nasal delivery. Microspheres composed of hydroxypropyl methylcellulose (H), chitosan (CS), carbopol 934P (CP) and various combinations of these mucoadhesive polymers, and maltodextrin (M), colloidal silicon dioxide (A), and propylene glycol (P) as filler and shaper, were prepared by spray-drying technique. Using propranolol HCl as a model drug, microspheres were prepared at loadings exceeding 80% and yields between 24% and 74%. Bulky, free flowing microspheres that had median particle size between 15 and 23 μm were obtained. Their zeta potential was according to the charge of polymer. Adhesion time of mucoadhesive microspheres on isolated pig intestine was ranked, CS 9 CP: H 9 CP 9 H, while the rank order of swelling was CP 9 CS 9 H. Increasing the amount of CP in CP:H formulations increased the percentage of swelling. Infrared (IR) spectra showed no interaction between excipients used except CS with acetic acid. The release of drug from CP and CP:H microspheres was slower than the release from H and CS microspheres, correlated to their viscosity and swelling. Long lag time from the CP microspheres could be shortened when combined with H. The permeation of drug through nasal cell monolayer corresponded to their release profiles. These microspheres affected the integrity of tight junctions, relative to their swelling and charge of polymer. Cell viability was not affected except from CS microspheres, but recovery could be obtained. In conclusion, spray-dried microspheres of H, CS, CP, and CP:H could be prepared to deliver drug through nasal cell monolayer via the opening of tight junction without cell damaging.

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Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: preparation and in vitro characterization

Cited by 71 publications

References 22 publications

Evaluation of Mechanical and Mucoadhesive Properties of Clomiphene Citrate Gel Formulations Containing Carbomers and Their Thiolated Derivatives

Evaluation of Mechanical and Mucoadhesive Properties of Clomiphene Citrate Gel Formulations Containing Carbomers and Their Thiolated Derivatives

Novel, Sustained-Release, Dry-Powder Inhalable Formulation for Montelukast Sodium

Spray-dried mucoadhesive microspheres: Preparation and transport through nasal cell monolayer

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