Mucoadhesive Microspheres for Controlled Drug Delivery

Chowdary, K. P. R.; Rao, Yarraguntla Srinivasa

doi:10.1248/bpb.27.1717

Cited by 155 publications

(93 citation statements)

References 68 publications

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“…They are an alternative to non-specific bioadhesives (Smart, 2005) because they bind or adhere to specific chemical structures on the cell or mucus surface. Good examples of these molecules are lectins, invasins, fimbrial proteins (Woodley, 2001), antibodies (Chowdary, Rao, 2004), and those obtained by the addition of thiol groups to known molecules (Bravo-Osuna et al, 2007).…”

Section: Second Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…Through the transmission of a cellular signal, this specific bond can result not only in bioadhesion but also in cellular internalization by different lysosomal and non-lysosomal mechanisms (Lehr, 2000). The most commonly found lectins are those isolated from Abrus precatroius, Agaricus bisporus, Anguilla anguilla, Arachis hypogaea, Pandeiraea simplicifolia, and Bauhinia purpurea (Chowdary, Rao, 2004). Bacterial invasins are proteins from the membrane of Yersinia pseudotuberculosis that stimulate fagocytosis at cellular membrane through linkage with integrin receptors (Chowdary, Rao, 2004;Lehr, 2000;Woodley, 2001).…”

Section: Second Generation Mucoadhesive Materialsmentioning

confidence: 99%

“…This adhesion is related to the pathogenicity of the bacteria. Bacterial adhesive factors can be an efficient mechanism of improving adhesion of mucoadhesive agents used in release systems (Chowdary, Rao, 2004).…”

Section: Second Generation Mucoadhesive Materialsmentioning

confidence: 99%

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Mucoadhesive drug delivery systems

Carvalho

Bruschi

Evangelista

et al. 2010

Braz. J. Pharm. Sci.

255

181

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Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.Uniterms: Mucoadhesion. Bioadhesion. Mucoadhesive systems. Drugs/delivery. O efeito de fármacos pode ser potencializado através do desenvolvimento de novos sistemas de liberação como os sistemas mucoadesivos. Estes sistemas permanecem em contato íntimo com o tecido de absorção, as mucosas, liberando o fármaco no local de ação, com o consequente aumento da biodisponibilidade, podendo promover efeitos locais e sistêmicos. A mucoadesão, atualmente, é explicada por seis teorias, a eletrônica, da adsorção, da molhabilidade, da difusão, da fratura e a mecânica. Para estudar seus mecanismos e quantificá-la, são propostas várias metodologias in vitro e in vivo. Porém, a mucoadesão ainda não é totalmente compreendida. Esse trabalho tem por objetivo revisar os mecanismos e as teorias envolvidas na mucoadesão, além de descrever as metodologias e os polímeros mais utilizados em sistemas mucoadesivos para liberação de fármacos.Unitermos: Mucoadesão. Bioadesão. Sistemas mucoadesivos. Fármacos/liberação.

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Section: Second Generation Mucoadhesive Materialsmentioning

confidence: 99%

Section: Second Generation Mucoadhesive Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Mucoadhesive drug delivery systems

Carvalho

Bruschi

Evangelista

et al. 2010

Braz. J. Pharm. Sci.

255

181

View full text Add to dashboard Cite

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“…In this work, we examine the hypothesis that mucoadhesive microparticles may offer a means for slow drug release from microparticles that remain adherent to the ocular surface for an extended time [3]. We therefore designed microparticles made of a blend of poly(lactic-co-glycolic acid) and poly(ethylene glycol), which are employed as the core material [4] and mucoadhesiveness promoter [5], respectively.…”

Section: Introductionmentioning

confidence: 99%

Mucoadhesive microparticles engineered for ophthalmic drug delivery

Choy

Park²,

Prausnitz

2008

Journal of Physics and Chemistry of Solids

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Although topical drug delivery is a convenient route of administration to treat various eye diseases, it has serious limitations due to rapid clearance of the formulation from the surface of the eye. In this study, we engineered microparticles for both sustained drug delivery and prolonged residence time on the extraocular surface. Microparticles were fabricated by emulsification using poly(lactic-co-glycolic acid) (PLG) and poly(ethylene glycol) (PEG) as the core material and mucoadhesion promoter, respectively. The particle size was controlled to be less than 10 µm to avoid eye irritation and for eventual clearance through the lacrimal canals. In vitro mucoadhesion tests showed that PLG microparticles with PEG adhered better to the mucous membrane under the conditions employed in this study compared to the microparticles without PEG. When an aqueous suspension of microparticles with PEG was administered topically to the rabbit eye in vivo, microparticles were seen for up to 30 min on the ocular surface in the cul-de-sac, which was a dramatic increase in residence time as compared to conventional eye drop formulations. We conclude that mucoadhesive microparticles are promising vehicles for ophthalmic drug delivery.

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“…Besides prolonging the residence time, mucoadhesive microspheres have additional advantages such as efficient absorption and enhanced bioavailability of the drugs, owing to a high surface-to-volume ratio and a much more intimate contact with the mucus layer. 40 In addition, the stability of antibiotic in the low pH should be taken into account for gastric mucoadhesive formulation since some antibiotics such as benzylpenicillin, macrolides and tetracyclines are unstable in acid. Chitosan microspheres for gastric mucoadhesive administration have been prepared and demonstrated to increase bioavailability of clarithromycin and tetracycline.…”

Section: Biodegradable Materialsmentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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Mucoadhesive Microspheres for Controlled Drug Delivery

Cited by 155 publications

References 68 publications

Mucoadhesive drug delivery systems

Mucoadhesive drug delivery systems

Mucoadhesive microparticles engineered for ophthalmic drug delivery

Recent advances in materials for extended-release antibiotic delivery system

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