2021
DOI: 10.22159/ijap.2021v13i1.39657
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Mucoadhesive Polymeric Films of Acyclovir Proniosomes for Buccal Administration

Abstract: Objective: The aim of the present work was to formulate and evaluate proniosomes of the poorly soluble drug, acyclovir incorporated in mucoadhesive polymeric films for improved buccal mucosal permeability of the drug while achieving prolonged release. Methods: Acyclovir was formulated as proniosomes using Span 60 and cholesterol. The prepared proniosomes were loaded into mucoadhesive polymeric films prepared with varying quantities of carbopol 934P and HPMC K15M. The proniosome incorporated films were ev… Show more

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