Mucoadhesive Solid Lipid Microparticles for Controlled Release of a Corticosteroid in the Chronic Obstructive Pulmonary Disease Treatment

Abstract

Aim: Therapeutic efficacy of pulmonary diseases is often limited and drug delivery systems offer new solutions to clinical problems. Solid lipid microparticles (SLMs) are suggested as systems for the delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi. Materials & methods: Here, we describe two novel different SLMs using chitosan and alginate such as mucoadhesive polymers and we also studied their biocompatibility and their effectiveness compared with the free drug in controlling senescence and inflammatory processes in cigarette smoke extracts. Results: Data reported show that fluticasone propionate (FP)-loaded SLMs are more effective than FP alone in controlling oxidative stress. Conclusion: The therapeutic approach using FP-loaded microparticles could be a promising strategy for the treatment of the chronic inflammatory pulmonary diseases.

Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock

“…Increased numbers of circulating plasma EVs have been reported in various diseases, including systemic sclerosis [40], cardiovascular disease [21], thrombocythemia [22], type 2 diabetes mellitus [23], congenital heart disease [24], preeclampsia [25], COPD [41], and sepsis‐induced microvascular dysfunction, immunosuppression, and acute kidney injury [35]. We next asked if we could detect differences in plasma EV concentrations between the critically ill, non‐septic control, sepsis, and septic shock patients.…”

“…Ageing and age‐related diseases, i.e. cancer [57], idiopathic pulmonary fibrosis (IPF) [41], sepsis [36,58], Alzheimer's disease [59,60], are characterized by alterations in 5‐methycytosine content resulting in genome‐wide hypomethylation and promoter‐specific hypermethylation. In sepsis, many studies show that pathogen infection can increase DNMT activity, DNMT mRNA expression, and DNA methylation in epithelial [61,62], endothelial [54,63], and dendritic cells [63,64].…”

Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

“…SLNs are among the lipid nanocarriers developed for transporting the hydrophobic bioactive compounds with higher loading capacity along with the enhanced stability of the loaded bioactive compounds. [54][55][56][57][58][59][60] SLNs showed higher loading efficacy and bioavailability of various plant bioactive compounds like curcumin, resveratrol, quercetin, and catechin. These plant-derived bioactive compound-loaded SLNs showed higher potential in the prevention and cure of various chronic diseases.…”

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

“…On the other side particles with >10 µm diameter is suitable for deposition in the oropharynx. The microparticle in 1-5 µm size range is considered asanideal to achieve efficacious pulmonary deposition [39,40]. to deliver the microemulsion.…”

“…et al described alginate and chitosan-basedmucoadhesive solid lipid microparticles (SLMs) for the effective delivery of fluticasone propionate to treat chronic obstructive pulmonary diseases (COPDs). The developed SLMs were more effective in controlling oxidative stress-induced lung inflammation including ERK1/2 pathway activation and cigarette smoke extract-inducedsurvivin expression[39]. Lymphocyte-derivedmicroparticles (LMPs) stimulate oxidative stress in endothelial cells[41].Qiuet al(2014) identified that LMPs cause apoptosis of alveolar epithelial and bronchial cells by the activation of p38 mitogen-activated protein kinase signaling with an increase in cellular oxidative stress and arachidonic acid production[42].The first report on the expression of lung vascular endothelial growth factor in benzo(a)pyrenefed mouse model ofa lungtumour was published by Bandi and co-workers.…”