Mucocoele and mucinous tumours of the appendix: A review of the literature

Rymer, Ben; Forsythe, Rachael; Husada, Glen

doi:10.1016/j.ijsu.2015.04.052

Cited by 59 publications

(96 citation statements)

References 25 publications

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“…Abdominal pain is the most common symptom of symptomatic patients. Other symptoms include abdominal mass, weight loss, nausea, vomiting, changes in bowel habits, unexplained anemia, obstipation, and lower gastrointestinal system bleeding (12). A large number of patients often admit to emergency service with one or more of these symptoms.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of appendiceal mucinous tumors: A single-center experience

2017

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Clinicopathological analysis of appendiceal mucinous tumors: A single-center experience INTRODUCTIONAppendiceal mucocele is a pathological process occurring due to mucosal inflammatory or neoplastic diseases that result in the formation of an enlarged appendix and thinned appendicular wall caused by abnormal accumulation of mucus in the appendicular lumen, depending on any obstructive etiologic agent. It is at least two times more common in women than in men, and is only observed in 0.2%-0.7% of all appendectomy specimens (1-3). Although it is one of the most common primary epithelial tumors in the appendix, it is a rare clinical condition compared with other pathologies. This disease has unpredictable biological behavior in consideration of its outcomes. There is a large body of literature showing that mucocele is an important pathological condition as spontaneous or iatrogenic ruptures lead to pseudomyxoma peritoneum (PP) syndrome, of which a complete treatment algorithm has not been established so far. Four different types of formations widely accepted in the literature are retention cysts, mucosal hyperplasia, cystadenoma, and cystadenocarcinoma. Although clinical presentation of mucocele is nonspecific, it is incidentally detected during appendectomies, which are mostly performed for acute appendicitis. Cystadenoma and cystadenocarcinoma have more clinical significance because spontaneous or iatrogenic rupture of these can lead to PP syndrome. Opting for open laparotomy in the presence of a mucocele detected during laparoscopic procedures is extremely important to ensure that all spaces in the peritoneal cavity are explored and that the appendix wall remains intact and does not lead to PP syndrome, which is considered to be malignant and develops as a result of rupture (4). Understanding the clinical and pathological profile of patients with appendiceal mucocele can help the clinicians in better diagnosis and management of this rare condition. Therefore, in this retrospective study, besides the clinical, radiological, and pathological profile of the patients with mucocele, we also aimed to focus on the surgical management of appendiceal mucinous tumors according to different types. Objective: Appendiceal mucinous tumors can be encountered in four different types. The clinical approach varies according to these types and the severity of the present disease. We aimed to share clinical, radiological, and pathological features and surgical options of the patients diagnosed with mucinous tumors at our center. MATERIAL AND METHODS Material and Methods:Between August 2009 and March 2016, 757 patients underwent appendectomy for presumed diagnosis of acute appendicitis at the Department of Surgery, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey. Among them, demographic, clinical, and histopathological characteristics of patients who diagnosed with appendiceal mucinous tumors were retrospectively analyzed. This study was approved by our faculty's human ethics committee.Results: Incidenc...

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Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of appendiceal mucinous tumors: A single-center experience

2017

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“…Os diagnósticos diferenciais da mucocele incluem hidrossalpingite, cisto mesentérico, apendicite aguda, cistos de ovário e renal, dentre outros 1,2,5,12,14,16,19,20 . É relatada na literatura a associação da mucocele com adenocarcinoma de cólon em um a cada cinco casos, enquanto que com cistoadenoma e cistoadenocarcinoma de ovário chega a 13% 3,5,8,9,[11][12][13][14][15][16][17][18] .…”

Section: Discussionunclassified

“…É relatada na literatura a associação da mucocele com adenocarcinoma de cólon em um a cada cinco casos, enquanto que com cistoadenoma e cistoadenocarcinoma de ovário chega a 13% 3,5,8,9,[11][12][13][14][15][16][17][18] . Neste contexto, a utilização de marcadores de doenças tumorais pode auxiliar na identificação de neoplasias de cólon ou ovário associadas à mucocele do apêndice, destacando-se a dosagem dos antígenos CEA e CA 50 3,8,12,13,17,19 . Também podemos encontrar associação com neoplasias de vesícula biliar, endométrio, mama, próstata, bexiga, rim 3,9,12,14 e estômago 15 .…”

Section: Discussionunclassified

“…Foi descrita inicialmente em 1842 por Rokitansky e formalmente denominada por Feren em 1876 1,4,13,[15][16][17] e consiste em uma doença rara, sendo observada em 0,07% a 0,7% das apendicectomias . Corresponde à 8% de todos os tumores do apêndice 5,7,15,17,[21][22][23] , predomina no sexo feminino, mais comumente na faixa etária acima de 50 anos [1][2][3][4][5][6]8,[12][13][14][15][16][17][18][19] . Pode causar dores abdominais agudas ou crônicas, de padrão variável, localizadas em quadrante inferior direito, por vezes associada à massa palpável em fossa ilíaca direita e perda de peso.…”

Section: Introductionunclassified

“…Pode causar dores abdominais agudas ou crônicas, de padrão variável, localizadas em quadrante inferior direito, por vezes associada à massa palpável em fossa ilíaca direita e perda de peso. Entretanto, é uma doença assintomática em cerca de 25% dos casos [1][2][3][4][5]8,9,11,[13][14][15][16][17][18][19][20] , sendo, na maioria das vezes, um achado incidental no momento da laparotomia. Exames de imagem e a dosagem de marcadores como os antígenos carcinoembrionário (CEA) e carboidrato (CA) 50 podem auxiliar o diagnóstico [1][2][3][4][5][6][7][8][9][10][11]13,14,17,18,21 .…”

Section: Introductionunclassified

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Mucocele de apêndice: Relato de dois casos e revisão literária

Batista¹,

Vieira²,

Vieira³

et al. 2018

R. Saúde

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ResumoA mucocele de apêndice ocorre após sua obstrução quando há acúmulo de material mucinoso em seu interior, dilatando assim sua luz. É uma doença rara e geralmente assintomática, sendo na maioria das vezes um achado incidental no momento da laparotomia. Todavia, pode cursar com dor abdominal, alterações de hábito intestinal, massa abdominal, sangramento intestinal, anemia e emagrecimento. O tratamento da mucocele é fundamentalmente cirúrgico e a complicação mais importante é o pseudomixoma peritoneal. Neste trabalho realizamos uma revisão literária e a descrição de dois casos sintomáticos de mucocele benigna do apêndice, diagnosticados e tratados no Hospital Escola Luiz Gioseffi Jannuzzi da Mucocele de apêndice: Relato de dois casos e revisão literária AbstractThe appendix mucocele occurs after its obstruction when there is accumulation of mucinous material in its interior, thus dilating its light. It is a rare and usually asymptomatic disease, most often an incidental finding at the time of laparotomy. However, they may have abdominal pain, changes in bowel habits, abdominal mass, intestinal bleeding, anemia, and weight loss. The treatment of mucocele is primarily surgical and the most important complication is peritoneal pseudomyxoma. In this work we performed a literary review and the description of two symptomatic cases of benign mucocele of the appendix diagnosed and treated at the Hospital Escola Luiz Gioseffi Jannuzzi of the Faculdade de Medicina de Valença (HELGJ-FMV), where the patients evolved well only after the surgical removal of the appendix.

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