Mucoepidermoid Carcinoma: A Demographic and Histopathological Profile

Niazi, Zainab

doi:10.35787/jimdc.v9i4.460

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Though there are studies where there is no significant difference is observed, but the results remained inconsistent (8). Mucoepidermoid type was predominant in our series, this was consistent with other studies (9). Other studies have also reported the same with second most common histological types being adenoid cystic carcinoma (6).…”

Section: Figure 1 Age Distribution Of Patients Presenting With Saliva...supporting

confidence: 79%

Analysis of pattern of salivary gland cancers: Descriptive analysis from a single center

Zulnoorain Qambar Shah,

Moiz Muhammad Shaikh,

Fasiha Shah

et al. 2024

LMRJ

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Salivary gland carcinomas are the malignant tumours arising from major or minor salivary glands, accounting for 5% of all head and neck cancers. There is scarce data available regarding pattern of presentation and clinical outcome of salivary glands in Pakistan. Thus this retrospective analysis of the patients presenting with salivary gland tumours was designed. A total of 305 patients were diagnosed with salivary gland cancers from 2008 till 2023, including 127 (41.6%) of females and 178 (58.4%) of male patients. There were 191 (62.6%) patients with parotid gland cancer and 114(37.4%) with submandibular and other minor glands. Mucoepidermoid carcinoma was the most prominent histological type followed by Adenoid Cystic carcinoma. Grade 2 (44.1%) was most frequently reported followed by Grade 1 (33.9%) and 3 (22.0%). These cancers did not show any significant association with age or gender. Salivary gland cancers are relatively rare cancer. Further studies to explore biological characteristics and long term clinical outcome are recommended.

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Section: Figure 1 Age Distribution Of Patients Presenting With Saliva...supporting

confidence: 79%

Analysis of pattern of salivary gland cancers: Descriptive analysis from a single center

Zulnoorain Qambar Shah,

Moiz Muhammad Shaikh,

Fasiha Shah

et al. 2024

LMRJ

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“…Recently a study was conducted in Armed Forces Institute of Pathology on 30 cases of MEC and it was reported that low grade MEC was most common tumor similar to result of this study. 28 There was certain limitation of the current study, which might be the cause of differences in results while comparing with other studies. Malignant salivary gland tumors are rare, therefore the sample size in the current study was small (n=55) so, it was difficult to evaluate the definitive role of Bcl-2.…”

Section: Discussionmentioning

confidence: 75%

Immunohistochemical Expression of BCL-2 in Malignant Salivary Gland Tumors

Rasul¹,

Wahid

Imran

et al. 2021

J Islamabad Med Dental Coll

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Background: Malignant salivary gland tumors (MSGTs) consist of a heterogeneous group of neoplasms with complex clinicopathological features and biological behaviors. The purpose of this study was to determine the expression of Bcl-2 antiapoptotic protein in mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ADCC), acinic cell carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) of salivary glands and to find out its association with different grades of these tumors. Material and Methods: This descriptive study included 55 cases of MSGTs. Tissue sections were stained with routine hematoxylin and eosin stain as well as Bcl-2 immunostain. MSGTs were graded as low grade (Low grade MEC, ACC, PLGA, and tubular pattern of ADCC), intermediate grade (cribriform pattern of ADCC, and intermediate grade of MEC) and high grade (high grade of MEC and solid pattern of ADCC) tumors on H&E sections. Bcl-2 expression was scored as ‘negative’ (<5% of neoplastic cells), ‘1’ (5-19% of neoplastic cells), ‘2’ (20-49% of neoplastic cells), and ‘3’ (>50% of neoplastic cells), respectively. Results: MSGTs most commonly involved the parotid gland (52.7%), while ADCC (40%) and MEC (38.2%) were the most common tumors. Expression of Bcl-2 was strongly positive in 56.4% cases of MSGTs which included ADCC (71%), MEC (19.4%) and ACC (9.7%), respectively. A significant association was found between Bcl-2 staining and types of MSGTs i.e., MEC, ADCC, ACC (P = .001) as well as between Bcl-2 staining and grades of MSGTs (P = .013). Conclusions: Bcl-2 protein is expressed in malignant salivary gland tumors. Its expression maybe helpful in grading small biopsies, predicting behavior, and planning targeted therapy of MSGTs.

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Mucoepidermoid Carcinoma: A Demographic and Histopathological Profile

Cited by 2 publications

References 3 publications

Analysis of pattern of salivary gland cancers: Descriptive analysis from a single center

Analysis of pattern of salivary gland cancers: Descriptive analysis from a single center

Immunohistochemical Expression of BCL-2 in Malignant Salivary Gland Tumors

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