Mucoepidermoid Carcinoma Arising in a Background of Sialadenoma Papilliferum: A Case Report

Liu, Wei; Gnepp, Douglas R.; Vries, E. de; Bibawy, Haidy; Solomón, Michael R.; Gloster, Elizabeth S.

doi:10.1007/s12105-009-0106-5

Cited by 28 publications

(18 citation statements)

References 12 publications

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“…The clinical findings for UKCD cases are summarized in Table 1 and are combined with the literature review cases in Table 2. Case reports alleging malignant transformation [8,[32][33][34][35] were excluded from our review because, in our opinion, there was insufficient evidence in the publications to support origin from a preexisting SP.…”

Section: Resultsmentioning

confidence: 99%

“…Based on the 27 cases in the literature with follow-up information, the recurrence rate is 7.4%. Cases of malignant transformation of SP have appeared in the literature; [8,[32][33][34][35] however, in our opinion, there is insufficient evidence in the publications to unequivocally determine whether any of the malignancies truly originated within a pre-existing SP. Although the case reported by Ide et al [8] may represent an SP with potentially malignant features, we could not entirely exclude a papillary cystadenocarcinoma with a surface papillomatosis based on the available photomicrographs.…”

Section: Discussionmentioning

confidence: 96%

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Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Fowler

Damm

2017

Head and Neck Pathol

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Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm that comprises from 0.4 to 1.2% of all salivary gland tumors. The tumor is so named because of its microscopic resemblance to the syringocystadenoma papilliferum, an uncommon benign tumor of sweat gland origin. The purpose of this paper is to report the clinical and microscopic features of seven new cases of SP and combine them with cases previously reported in the English language literature to further define this unusual lesion. Combining our cases with acceptable cases from the literature, the palate (especially the hard palate) was the most common site, with 80% of the cases occurring in this location. Other locations in decreasing order were buccal mucosa, upper lip, retromolar pad, and parotid gland. Age at diagnosis ranged from 18 to 87 years with a peak in the 6th decade and an average age of 56.4 years. Microscopically, the lesions demonstrated a papillary surface morphology, and the papillary projections varied from long and pointed to short and blunted. The supporting connective tissue contained a variable number of convoluted ductal structures, which often fused with the overlying surface epithelium. The ductal structures exhibited papillary infoldings and were lined by a double layer of epithelium consisting of basal cell layer and a luminal layer of cuboidal-to-columnar ductal cells. Immunohistochemical reactivity with p63 and p40 indicated that the basal cell layer was comprised predominantly of neoplastic myoepithelial cells. The luminal cells were immunoreactive with epithelial membrane antigen characteristic of ductal cell differentiation. Conservative surgical treatment was accomplished in most cases and appears to be adequate treatment as only two recurrences were documented. Several case reports of purported malignant transformation in SP have been reported in the literature, but in our opinion, there is insufficient evidence in the publications to unequivocally determine whether any of the malignancies truly originated within a pre-existing SP.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Fowler

Damm

2017

Head and Neck Pathol

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“…SP generally runs a benign course, but lack of encapsulation around the proliferating ductal components may give an erroneous impression of malignancy [ 3 , 7 ]. Rare recurrent cases have been reported [ 9 ] and malignant transformation of SP has only recently been recognized [ 2 , 6 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sialadenoma Papilliferum with Inverted Pattern in a Young Patient: A Case Report

Costa

Vázquez

2015

Am J Case Rep

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Patient: Male, 20Final Diagnosis: Sialadenoma papilliferum with inverted patternSymptoms: Intraoral nodular massMedication: —Clinical Procedure: Surgery – excisionSpecialty: SurgeryObjective:Challenging differential diagnosisBackground:Sialadenoma papilliferum (SP) is a rare, benign neoplasm of salivary gland origin which manifests as an exophytic papillary excrescence of the mucosa. Indeed, SP is both an exophytic proliferation of papillary stratified squamous epithelium above the mucosal surface and an endophytic salivary ductal proliferation beneath the mucosa. It arises predominantly in minor salivary glands and usually affects patients in the age range of 32–87 years, with reports in young patients being exceedingly rare.Case Report:We report the case of a previously healthy 20-year-old man diagnosed with a nodular mass in the upper lip buccal mucosa. The tumor was excised and submitted for microscopic examination.Histologic examination revealed a biphasic proliferation of papillary stratified squamous and salivary ductal epithelia, both underneath the mucosal surface.Conclusions:In this unique case, as the classical SP, the tumor had a biphasic proliferation of squamous and ductal epithelia. However, unlike the classical SP, both epithelia grew under the mucosal surface. As a result, it did not manifest as an exophytic proliferation, but as a nodule. We excluded squamous papilloma, inverted ductal papilloma, intraductal papilloma and mucoepidermoid carcinoma, the principal entities in the differential diagnosis of SP, and concluded it was an SP with inverted pattern.

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“…Considering the absence of proliferative small ducts in the submucosa, the diagnosis of papillary squamous cell carcinoma extending into the salivary duct fits best. A coexistent mucoepidermoid carcinoma was found in a tongue SP by Liu et al 6. On the basis of its location along the salivary duct, their lesion may represent an intraductal mucoepidermoid carcinoma protruding from the mucosal orifice where squamous metaplasia and papillary hyperplasia of the ductal epithelium occur as a blockade phenomenon.…”

Section: Discussionmentioning

confidence: 95%

Sialadenoma papilliferum with potentially malignant features

et al. 2010

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Sialadenoma papilliferum (SP) is a benign non-invasive lesion with slow and limited growth. This report describes an unusual SP that enlarged rapidly and presented as an extensive intraoral tumour highly suspicious for verrucous carcinoma. Radiographic resorption of the underlying bone was evident in the mandible. This type of destructive growth does not conform to any previously reported SP. Histological features were also atypical: surface verrucous hyperplasia and deeper florid cystic-duct adenoma. Overall, the SP is likely to be considered a borderline lesion with malignant potential. Four published cases of malignancy associated with SP showed completely different clinical and pathological settings, further obfuscating the concept of malignant SP.

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Mucoepidermoid Carcinoma Arising in a Background of Sialadenoma Papilliferum: A Case Report

Cited by 28 publications

References 12 publications

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Sialadenoma Papilliferum with Inverted Pattern in a Young Patient: A Case Report

Sialadenoma papilliferum with potentially malignant features

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