Sialadenoma papilliferum with potentially malignant features

Ide, Fumio; Kikuchi, Kanako; Kusama, Kaoru; Kanazawa, Hisanori

doi:10.1136/jcp.2009.072660

Cited by 18 publications

(19 citation statements)

References 11 publications

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“…Although there have been a few reports of recurrence and malignant transformation, in which SP has reported that it can transformed into epithelial-muscle epithelial carcinoma, squamous cell carcinoma, and mucoepidermoid carcinoma, but malignant transformation is rare and not entirely convincing [6,16,32,47]. As the results of the statistics show that the prognosis of this lesion is very good, we believe that SP does not have malignant potential [14,44,48].…”

Section: Discussionmentioning

confidence: 90%

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

et al. 2021

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Background Sialadenoma papilliferum (SP) is an extremely rare benign neoplasm of salivary glands. To explore and define the clinicopathological features of SP, we retrospectively analyzed 89 cases previously reported and five new cases. Methods The clinical features, histopathology, immunohistochemistry and molecular analysis of our cases were further performed and the related literatures were reviewed and analyzed. Results Combining 89 cases from the literature with our cases, the hard palate was the most common locations for SP. However, two of our cases were rarely located in the esophageal mucosa. Among all cases, the male gender was more affected, with the average age and median age of 61.8 and 62 years, respectively. Conventional histomorphologically, SP was characterized by complex papillary structures with a biphasic growth pattern of exophytic squamous component and endophytic glandular component. The glandular structures were lined by a double layer of epithelium composed of flattened or cuboidal basal cells and a cuboidal or columnar luminal cells formed papillary infoldings into the ductal lumina. Immunohistochemically, the luminal epithelial configurations showed strong expression of CK7 along the luminal cell membrane, while the basal myoepithelia displayed strong nuclear p63 expression. In both the glandular and squamous tumour components showed BRAF V600E-positive immunostaining and BRAF V600E mutation. Conclusion For the first time, we have comprehensively aggregated and analyzed 90 cases sialadenoma papilliferum from almost all previous publications, and further explored the clinicopathological features of SP; concordantly, this study demonstrated that SP shows a papillomatous growth pattern with exophytic and endophytic proliferation of ductal epithelium composed of double-layered cells harboring BRAF V600E mutation. Additionly, adequate treatment for SP is surgical excision, with a favorable prognosis in patients.

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Section: Discussionmentioning

confidence: 90%

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

et al. 2021

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“…The clinical findings for UKCD cases are summarized in Table 1 and are combined with the literature review cases in Table 2. Case reports alleging malignant transformation [8,[32][33][34][35] were excluded from our review because, in our opinion, there was insufficient evidence in the publications to support origin from a preexisting SP.…”

Section: Resultsmentioning

confidence: 99%

“…Cases of malignant transformation of SP have appeared in the literature; [8,[32][33][34][35] however, in our opinion, there is insufficient evidence in the publications to unequivocally determine whether any of the malignancies truly originated within a pre-existing SP. Although the case reported by Ide et al [8] may represent an SP with potentially malignant features, we could not entirely exclude a papillary cystadenocarcinoma with a surface papillomatosis based on the available photomicrographs. Surface papillomatosis (papillary epithelial hyperplasia) previously has been described overlying other malignant salivary gland neoplasms, most often polymorphous adenocarcinoma [41].…”

Section: Discussionmentioning

confidence: 96%

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Fowler

Damm

2017

Head and Neck Pathol

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Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm that comprises from 0.4 to 1.2% of all salivary gland tumors. The tumor is so named because of its microscopic resemblance to the syringocystadenoma papilliferum, an uncommon benign tumor of sweat gland origin. The purpose of this paper is to report the clinical and microscopic features of seven new cases of SP and combine them with cases previously reported in the English language literature to further define this unusual lesion. Combining our cases with acceptable cases from the literature, the palate (especially the hard palate) was the most common site, with 80% of the cases occurring in this location. Other locations in decreasing order were buccal mucosa, upper lip, retromolar pad, and parotid gland. Age at diagnosis ranged from 18 to 87 years with a peak in the 6th decade and an average age of 56.4 years. Microscopically, the lesions demonstrated a papillary surface morphology, and the papillary projections varied from long and pointed to short and blunted. The supporting connective tissue contained a variable number of convoluted ductal structures, which often fused with the overlying surface epithelium. The ductal structures exhibited papillary infoldings and were lined by a double layer of epithelium consisting of basal cell layer and a luminal layer of cuboidal-to-columnar ductal cells. Immunohistochemical reactivity with p63 and p40 indicated that the basal cell layer was comprised predominantly of neoplastic myoepithelial cells. The luminal cells were immunoreactive with epithelial membrane antigen characteristic of ductal cell differentiation. Conservative surgical treatment was accomplished in most cases and appears to be adequate treatment as only two recurrences were documented. Several case reports of purported malignant transformation in SP have been reported in the literature, but in our opinion, there is insufficient evidence in the publications to unequivocally determine whether any of the malignancies truly originated within a pre-existing SP.

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“…The present SP size matches the one reported in the literature, as it does not exceed 2 cm (16). The majority of the cases reviewed (41 out of 50, 82%) match this criteria; however, five cases included SP lesions bigger than 2 cm (1,13,14,31,37).…”

Section: Discussionmentioning

confidence: 99%

Sialadenoma papilliferum: Bibliometric analysis

Vasconcelos¹,

Gerber²,

Saraiva³

et al. 2019

J Clin Exp Dent

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BackgroundSialadenoma papilliferum is a benign rare condition of salivary glands showing a characteristic papillary growth of the ductal epithelium that ends up being confused with more frequent lesions of the oral cavity. Objectives: To perform a bibliometric analysis of all articles about Sialadenoma papilliferum in the oral cavity and to add a singular case report of Sialadenoma in the lower lip.Material and MethodsA total of 36 publications referring to Sialadenoma papilliferum in the oral cavity from the PubMed platform was reviewed. The specific data were collected, and a bibliometric analysis was performed using Microsoft Excel. The results obtained were then compared with this new case report.ResultsThe people most affected with sialadenoma were white males at the average age of 56. The lesion was asymptomatic, usually white or red, with an average size of 1.4 cm, and the palate was by far the most affected site. The majority of the lesions were excised, and only two cases indicated recurrence.ConclusionsWith surgical removal, Sialadenoma papilliferum has a favorable prognosis and no further treatment is required. Due to few recorded cases of recurrence, a long follow-up period is recommended to ensure that the lesion does not redevelop. Key words:Sialadenoma papilliferum, salivary gland, oral cavity, bibliometric analysis.

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Sialadenoma papilliferum with potentially malignant features

Cited by 18 publications

References 11 publications

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Sialadenoma papilliferum: Bibliometric analysis

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