Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature

Camelo-Piragua, Sandra; Habib, Claudine; Kanumuri, Prathima; Lago, Claudia; Mason, Holly; Otis, Christopher N.

doi:10.1016/j.humpath.2008.11.004

Cited by 53 publications

(54 citation statements)

References 18 publications

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“…The Crtc1-Maml2 fusion transcript was subsequently identified in primary thyroid, breast, cervix, lung and cutaneous sweat gland tumors with clear-cell, mucoepidermoid tumor-like histological features (Enlund et al, 2004;Behboudi et al, 2005;Kazakov et al, 2007;Tirado et al, 2007;Achcar et al, 2009;Camelo-Piragua et al, 2009;Kaye, 2009;Lennerz et al, 2009) unifying a group of tumors that arise from mucous/serous glands scattered throughout the body. As Crtc gene members are potent cAMP/CREB co-activators (Conkright et al, 2003;Iourgenko et al, 2003) and the ectopic expression of Crtc1-Maml2 activated a similar group of target genes (Coxon et al, 2005;Wu et al, 2005), a current model proposes that the fusion oncogene transforms cells by aberrantly co-activating specific Crtc1-inducible targets (Kaye, 2006).…”

Section: Introductionmentioning

confidence: 99%

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

et al. 2009

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Activation of Crtc1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of malignant salivary gland tumors. As LKB1 is a target for mutational inactivation in lung cancer and was recently shown to regulate hepatic Crtc2/CREB transcriptional activity in mice, we now present evidence suggesting disruption of an LKB1/Crtc pathway in cancer. Although Crtc1 is preferentially expressed in adult brain tissues, we observed elevated levels of steadystate Crtc1 in thoracic tumors. In addition, we show that somatic loss of LKB1 is associated with underphosphorylation of endogenous Crtc1, enhanced Crtc1 nuclear localization and enhanced expression of the Crtc prototypic target gene, NR4A2/Nurr1. Inhibition of NR4A2 was associated with growth suppression of LKB1 null tumors, but showed little effect on LKB1-wildtype cells. These data strengthen the role of dysregulated Crtc as a bona fide cancer gene, present a new element to the complex LKB1 tumorigenic axis, and suggest that Crtc genes may be aberrantly activated in a wider range of common adult malignancies.

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Section: Introductionmentioning

confidence: 99%

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

et al. 2009

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“…Because salivary and mammary glands are both tubuloacinar exocrine glands, some of their tumors, including mucoepidermoid carcinomas, share morphological, immunohistochemical and molecular features [2,7]. However, they have different incidences and clinical behaviors when they develop as primary salivary gland or primary breast tumors.…”

Section: Discussionmentioning

confidence: 99%

“…High-grade mucoepidermoid tumors have epidermoid and mucinous cells present as isolated elements with focal necrosis [6]. Reports about in situ components found in these tumors are contradictory [2,7,8]. In mucoepidermoid carcinomas of the breast, the Elston and Ellis [9] histologic classification, which is widely used to classify invasive breast carcinomas, correlates with the Ellis and Auclair [10] classification used for salivary gland mucoepidermoid carcinomas [12].…”

Section: Introductionmentioning

confidence: 99%

Primary mucoepidermoid carcinoma of the breast: a with immunohistochemical analysis and comparison with salivary gland mucoepidermoid carcinomas

Palermo¹,

Pinto²,

Zanetti³

et al. 2013

pjp

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Mucoepidermoid carcinomas in mammary glands represent 0.3% of all breast tumors. Features of salivary gland mucoepidermoid carcinoma have been used in studies concerning mucoepidermoid carcinomas of the breast because both share similar morphologic and molecular features. We report a case of primary mucoepidermoid carcinoma of the breast with an immunohistochemistry staining panel. We verified that MUC5AC occurs in more than 50% of high-grade tumors, and MUC1 correlates with shorter disease-free survival. The comparative analysis of mucin profiles may provide further insights into the clinical behavior of these tumors.

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“…Salivary gland-like tumors of the breast have been divided into tumors with myoepithelial differentiation (e.g., pleomorphic adenoma) and tumors devoid of myoepithelial differentiation (e.g., MEC) [3,7,9]. MEC of the breast, a variant of breast carcinoma, is a rare primary tumor, accounting for an incidence of approximately 0.2-0.3% [7,10,11].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment choices include excision, radiotherapy, and chemotherapy. Patchefsky et al [6,7] first reported MEC of the breast in 1979. Since then, 30 cases of breast MEC have been reported in the literature, all of them case reports.…”

Section: Introductionmentioning

confidence: 99%

Mucoepidermoid Carcinoma in a Breast Affected by Burn Scars: Comprehensive Literature Review and Case Report

Başbuğ¹,

Akbulut²,

Arıkanoğlu³

et al. 2011

Breast Care

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Background: Mucoepidermoid carcinoma (MEC), which is primarily found in the salivary glands, is rarely seen in the breast. These tumors usually develop from squamous and mucus-secreting cells. Histological grading is an important prognostic factor. Case Report: We present herein a case of a 69-year-old female patient with a painful mass in the left breast. Of importance is that, in addition to MEC, the patient had a wide area of scar tissue secondary to a burn that completely occupied the left bottom quadrant of the abdomen and retracted the left nipple up to the left upper quadrant. Fine needle aspiration biopsy was negative, and a lumpectomy was performed. Because the pathology results were consistent with MEC, modified radical mastectomy with subsequent adjuvant chemotherapy and radiotherapy was performed. The patient remained disease-free for 12 months after the treatment. In addition to a discussion of this case, we performed a review of the clinicopathological characteristics of 30 cases with breast MEC reported in the English language literature between 1979 and 2010. Conclusions: MEC of the breast is a rarely seen tumor, and this is the first report of MEC in a breast affected by burn scars.

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Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature

Cited by 53 publications

References 18 publications

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

Primary mucoepidermoid carcinoma of the breast: a with immunohistochemical analysis and comparison with salivary gland mucoepidermoid carcinomas

Mucoepidermoid Carcinoma in a Breast Affected by Burn Scars: Comprehensive Literature Review and Case Report

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