Mucoepidermoid carcinoma of the salivary glands.

Rapidis, Alexander D.; Givalos, N.; Gakiopoulou, Hariklia; Stavrianos, S.; Faratzis, G.; Lagogiannis, George; Katsilieris, I.; Patsouris, Efstratios

doi:10.1016/j.oraloncology.2006.03.001

Cited by 98 publications

(36 citation statements)

References 31 publications

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“…A) During the healing process, minimal complications such as infection, hematoma, or partial necrosis were noted11. However, these complications have rarely been reported, and as in our previous study, most cases of BFP flap successfully covered the saucerization defect without any complications14. In the present case, the grafted BFP was completely epithelialized and covered the defect.…”

Section: Discussionsupporting

confidence: 67%

“…Low-grade MEC is surgically excised in a single piece along with the involved underlying mucosa and bone for an adequate tumor-free margin5. High-grade MEC has local infiltration and regional lymph node metastasis1415, requiring wider surgical resection with postoperative radiotherapy or chemotherapy116. Lymph node metastasis can occur in low-grade MEC1.…”

Section: Discussionmentioning

confidence: 99%

“…The hard palate is a frequently involved site of low-grade MEC14. We surgically resected low-grade MEC on the left maxillary alveolus and hard palate and successfully covered the large defect with a BFP flap.…”

Section: Discussionmentioning

confidence: 99%

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Reconstruction of partial maxillectomy defect with a buccal fat pad flap and application of 4-hexylresorcinol: a case report

Seok

Kim

2016

J Korean Assoc Oral Maxillofac Surg

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Mucoepidermoid carcinoma (MEC) is the most common type of malignant neoplasm in the minor salivary gland. The hard palate is a frequently involved site of MEC. The treatment of low-grade MEC on the hard palate is wide local resection with a tumor-free margin. In the present case, the maxillary defect was reconstructed using a buccal fat pad (BFP) flap, followed by application of 4-hexylresorcinol (4HR) ointment for 2 weeks. The grafted BFP successfully covered the tumor resection defect without tension and demonstrated complete re-epithelialization without any complications.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reconstruction of partial maxillectomy defect with a buccal fat pad flap and application of 4-hexylresorcinol: a case report

Seok

Kim

2016

J Korean Assoc Oral Maxillofac Surg

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“…35 In addition, post-operative irradiation for MEC patients with positive surgical margin has been reported to be effective 36. Since high grade MECs have a high incidence of local recurrence (up to 50 percent), postoperative radiotherapy is recommended in these cases.…”

Section: Managementmentioning

confidence: 99%

Clinical Features and Differential Diagnoses in Laryngeal Mucoepidermoid Carcinoma

Mokhtari

2011

Clin Med�Insights�Pathol

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Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. However, it is a rare entity in larynx. Laryngeal cases are frequently misdiagnosed with other malignancies and they are under-reported. So, recognizing the clinical and histological features of this tumor is essential. Laryngeal mucoepidermoid carcinoma can arise in supraglottis, glottis and subglottis. Generally, it presents as a submucosal mass; therefore, progressive symptoms without any identifiable lesion in laryngoscopy must be well considered. The prognosis is somehow dependent on the histological features. In high-grade tumors, recurrence is more common and radical surgery with radiotherapy is recommended. In this paper, we provide a thorough literature review on mucoepidermoid carcinoma in the larynx. The most important distinguishing features of mucoepidermoid carcinoma and its two major differential diagnoses (squamous cell carcinoma and adenosquamous carcinoma) are clearly stated and pitfalls in true diagnosis of this tumor are discussed.

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“…Its clinical behavior is highly variable and ranges from slow-growing and indolent to locally aggressive and highly metastatic (11,12). Histologically, mucoepidermoid carcinoma is comprised of 3 different cell types: mucinous cells, intermediate cells and epidermoid cells.…”

Section: Introductionmentioning

confidence: 99%

Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

et al. 2013

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Parathyroid hormone-related protein (PTHrP) is known to induce bone resorption by activating RANKL as well as PTH. PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma. PTHrP expression in oral squamous carcinoma cell lines was investigated, and PTHrP was expressed in oral squamous cell carcinoma cell lines similar to that in a prostate carcinoma cell line. Mucoepidermoid carcinoma is the most common malignant salivary gland tumor composed of different types of cells including a squamous component. Its clinical behavior is highly variable and ranges from slow-growing and indolent to locally aggressive and highly metastatic. We examined the PTHrP expression in mucoepidermoid carcinoma and assessed the significance of its correlation with clinicopathological features. Immunohistochemical detection of PTHrP was carried out in 21 cases of mucoepidermoid carcinoma in the head and neck region. PTHrP was highly detectable in intermediate and epidermoid cells, and abundant expression of PTHrP in intermediate cells had a significant association with cancer malignancy, including lymph node metastasis and/or tumor recurrence. These results suggest that PTHrP expression can be used as a prognostic factor for mucoepidermoid carcinoma.

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Mucoepidermoid carcinoma of the salivary glands.

Cited by 98 publications

References 31 publications

Reconstruction of partial maxillectomy defect with a buccal fat pad flap and application of 4-hexylresorcinol: a case report

Reconstruction of partial maxillectomy defect with a buccal fat pad flap and application of 4-hexylresorcinol: a case report

Clinical Features and Differential Diagnoses in Laryngeal Mucoepidermoid Carcinoma

Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

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