Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

Nagamine, Kyosuke; Kitamura, Tatsuya; Yanagawa‐Matsuda, Aya; Ohiro, Yoichi; Tei, Kanchu; Hida, Kyoko; Higashino, Fumihiro; Totsuka, Yasunori; Shindoh, Masanobu

doi:10.3892/or.2013.2393

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…The relationship of IL‐11 to tumor progression and metastasis has been described in other cancers, such as bladder cancer and renal carcinoma . Likewise, PTHrP expressed in OSCCs and other malignant tumors seems to stimulate the activity of osteoclasts, acting both in osteoclastic and osteoblastic cells; moreover, it is related to increased tumor cell proliferation, survival, adhesion, migration and invasion, and is considered an indicator of the prognosis . Related to this, the present study showed that SCC9 cells expressed the IL‐11 and PTHrP genes, which is in agreement with previous reports .…”

Section: Discussionsupporting

confidence: 91%

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells

Schalch

Fernandes

Costa‐Rodrigues

et al. 2016

Journal of Biophotonics

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The treatment for oral cancer usually involves surgical excision followed by chemotherapy and/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (PBM) therapy has been used successfully to reduce the oral mucositis, however there is still some controversy regarding the effects of this therapy on unintentionally irradiated tumor cells that may remain after cancer treatment. The aim of this study was to analyze the effect of PBM therapy (using parameters for mucositis) on the modulation of osteoclastogenic potential of a cell line derived from human lingual squamous cell carcinoma (SCC9). Previously irradiated SCC9 cells were co-cultured with human osteoclast precursors. Co-cultures performed with non-irradiated SCC9 cells served as control. After 7, 14 and 21 days the co-cultures were evaluated for the tartrate-resistant acid phosphatase (TRAP) activity, an osteoclastogenic marker. Additionally, the monocultures of SCC9 cells (non-irradiated and irradiated) were analyzed for cell viability/proliferation and for the expression of IL-11 and PTHrP. The irradiation of SCC9 cells with PBM with an energy density of 4 J/cm decreased the pro-osteoclastogenic potential of those cells. This may represent a potential useful side effect of PBM therapy. PBM (using recommended parameters for mucositis treatment) decreases the osteoclastogenic potential of oral squamous carcinoma cells.

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Section: Discussionsupporting

confidence: 91%

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells

Schalch

Fernandes

Costa‐Rodrigues

et al. 2016

Journal of Biophotonics

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“…Nagao et al reported that GLI2 acts as an oncogene in regards to the proliferation and metastasis in osteosarcoma (5,9). PTHRP1 is known as a downstream factor of GLI2 and is involved in numerous types of tumors including osteosarcoma (23)(24)(25)(26)(27)(28). Ho et al found that knockdown of PTHR1 decreased the invasion and growth and increased tumor differentiation in osteosarcoma cells (29).…”

Section: Discussionmentioning

confidence: 99%

miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells

Wang

Liu

et al. 2017

Oncol Rep

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MicroRNAs (miRNAs) have been reported as key regulators in numerous diseases including osteosarcoma. The function of microRNA-141-3p (miR-141-3p) and whether this function is achieved by regulation of GLI family zinc finger 2 (GLI2) in osteosarcoma remain unclear. In the present study, we found decreased expression of miR-141-3p, but increased expression of GLI2 in osteosarcoma tissues and cell lines. In addition, we demonstrated a negative correlation between miR-141-3p and GLI2. Furthermore, we revealed that elevation of miR-141-3p resulted in a marked inhibition of proliferation and promotion of apoptosis as well as an obviously decrease in GLI2 in osteosarcoma cell lines. Furthermore, we determined that GLI2 is a target of miR-141-3p by a constructed luciferase assay. In addition, we showed that miR-141-3p could negatively regulate GLI2 and its downstream parathyroid hormone-related protein 1 (PTHRP1). Finally, through a series of antisense experiments we confirmed that the effect of miR-141-3p on proliferation and apoptosis was achieved through the GLI2 pathway in osteosarcoma cells. The findings of the present study may provide a new target for treating osteosarcoma.

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“…Salivary gland tumors are mostly benign and pleomorphic adenoma is their most common benign type, which is best treated by surgery and has an excellent prognosis. [1,2] Salivary gland tumors are usually developed in major salivary glands. Malignant salivary gland neoplasms comprise 5% of all head and neck cancers and are developed in women in the 5 th and 6 th decades of life.…”

Section: Introductionmentioning

confidence: 99%

Eosinophil Density in Common Benign and Malignant Salivary Gland Tumors with Congo Red Staining

Seifi

Azizi

Ghanghermeh

et al. 2019

Indian Journal of Medical and Paediatric Oncology

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Purpose: Eosinophils are multifunctional leukocytes with unknown mechanisms in salivary gland tumors. Some researchers associate eosinophils with tumor progression and others have proposed them as antitumoral. The present study was conducted to compare the density of eosinophils in common salivary gland tumors and its relationship with the degree of differentiation in malignant salivary gland tumors. Materials and Methods: In this present descriptive-analytical, cross-sectional study, 15 cases of pleomorphic adenoma, 15 cases of adenoid cystic carcinoma (ACC), 30 cases of mucoepidermoid carcinoma (MEC), and 5 cases of normal salivary glands were extracted. Sections were prepared of these cases for Congo red staining. The malignant salivary gland tumors were classified as high-grade and low-grade malignancies. The slides were observed under ×10, and the highest-density areas were selected and counted in ten microscopic fields under ×40. Results: The density of the eosinophils was 4.5 ± 5.6 in the pleomorphic adenoma, 16.2 ± 6.01 in the low-grade MEC, 1.05 ± 1.1 in the high-grade MEC (Grade III), and the ACC, and 0.4 ± 0.89 in the normal salivary gland. Eosinophil density was significantly higher in low-grade malignancies compared to in benign or high-grade malignant neoplasms and normal salivary gland ( P < 0.001). Conclusion: This is suggested which the density of eosinophils is associated with the process of tumorigenesis and the degree of malignancy in malignant salivary gland tumors.

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Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

Cited by 4 publications

References 22 publications

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells

miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells

Eosinophil Density in Common Benign and Malignant Salivary Gland Tumors with Congo Red Staining

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