INTRODUÇÃO: As disfunções temporomandibulares apresentam manifestações clínicas variadas, porém com alta prevalência de alterações posturais e impacto na qualidade de vida destes indivíduos. OBJETIVO: Caracterizar o grau de disfunção temporomandibular (DTM) e relacionar com a postura cervical e com a qualidade de vida em universitários. Método: Foram selecionados 98 indivíduos, de ambos os gêneros, com faixa etária entre 18 a 33 anos, através dos questionários, Índice Anamnético de Fonseca, que gradua a severidade da DTM e a versão brasileira do questionário de qualidade de Vida SF-36. A análise da postura de cabeça e pescoço foi realizada pelo software AlcimagemÒ, que oferece uma análise quantitativa dos ângulos. RESULTADOS: 68,36% apresentaram DTM Leve, 23,47% Moderada e 8,16% Severa;os mesmos apresentaram prejuízo principalmente nos domínios Vitalidade e Dor (X²= 0,03), sendo que Aspectos Emocionais e Sociais foram os domínios mais preservados. A média do ângulo cervical em indivíduos com DTM foi 90,76°(±7,72), sendo que há um aumento do ângulo cervical relacionado ao aumento do grau de severidade da DTM, porém não significante estatisticamente (r= 0,09). CONCLUSÃO: Houve uma prevalência maior de Disfunção Temporomandibular (DTM) leve, sendo que em relação ao ângulo cervical, houve um aumento com a severidade do grau de DTM, com piora da qualidade de vida nesta população.

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Bioactive glasses (BGs) are known for their ability to bond to living bone and cartilage. In general, they are readily available in powder and monolithic forms, which are not ideal for the optimal filling of bone defects with irregular shapes. In this context, the development of BG-based scaffolds containing flexible fibres is a relevant approach to improve the performance of BGs. This study is aimed at characterizing a new, highly porous, fibrous glassy scaffold and evaluating its in vitro and in vivo biocompatibility. The developed scaffolds were characterized in terms of porosity, mineralization and morphological features. Additionally, fibroblast and osteoblast cells were seeded in contact with extracts of the scaffolds to assess cell proliferation and genotoxicity after 24, 72 and 144 h. Finally, scaffolds were placed subcutaneously in rats for 15, 30 and 60 days. The scaffolds presented interconnected porous structures, and the precursor bioglass could mineralize a hydroxyapatite (HCA) layer in simulated body fluid (SBF) after only 12 h. The biomaterial elicited increased fibroblast and osteoblast cell proliferation, and no DNA damage was observed. The in vivo experiment showed degradation of the biomaterial over time, with soft tissue ingrowth into the degraded area and the presence of multinucleated giant cells around the implant. At day 60, the scaffolds were almost completely degraded and an organized granulation tissue filled the area. The results highlight the potential of this fibrous, glassy material for bone regeneration, due to its bioactive properties, non-cytotoxicity and biocompatibility. Future investigations should focus on translating these findings to orthotopic applications. Copyright © 2015 John Wiley & Sons, Ltd.

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The treatment of squamous cell carcinoma (SCC) involves surgery, chemotherapy, and/or radiotherapy, which can cause mucositis (inflammation of the oral mucosa that causes considerable pain and can compromise the continuity of oncological treatment). Photobiomodulation (PBM) has been successfully used in the treatment of mucositis, but doubts arise regarding the use of laser for areas in which tumor cells may remain. In this study, the effect of PBM on the viability, mitochondrial activity, proliferation, apoptosis, and migration of cells derived from oral SCC was evaluated. SCC9 cells were irradiated with laser (660 and 780 nm, using 11 dosimetric parameters) and submitted to mitochondrial and caspase 3 activity tests after 1 and 3 days. Based on the results, cell viability (neutral red assay), proliferation (BrdU assay), and migration (scratch-wound assay) were evaluated using only the dosimetric parameters recommended for mucositis. Non-irradiated cells served as the control. The experiments were performed in triplicate. The 11 parameters diminished mitochondrial activity and induced tumor cell apoptosis. Using the parameters recommended for mucositis, irradiation with 780 nm (70 mW, 4 J/cm) proved to be the safest and led to a reduction in cell viability, the induction of apoptosis, and a reduction in the migration capacity of the tumor cells.