Mucosa-Associated Lymphoid Tissue Lymphoma of the Esophagus Coexistent with Bronchus-Associated Lymphoid Tissue Lymphoma of the Lung

Chung, Jae Joon; Kim, Do Young; Kie, Jeong Hae; Kim, Ki Whang

doi:10.3349/ymj.2005.46.4.562

Cited by 17 publications

(13 citation statements)

References 13 publications

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“…Within the gastrointestinal tract, the stomach is the most common site of MALT lymphoma, and the esophagus is the least common site, accounting for only approximately 1% of gastrointestinal occurrences . Many esophageal MALT lymphoma cases were diagnosed by using surgical biopsy, endoscopic mucosal resection (EMR), and endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) . Pathological diagnosis by using endoscopic forceps biopsy is difficult because esophageal MALT lymphoma is obscured by the overlying mucosa, and therefore, it appears similar to an esophageal submucosal tumor.…”

Section: Introductionmentioning

confidence: 99%

Primary esophageal mucosa-associated lymphoid tissue lymphoma diagnosed by using stacked forceps biopsy

et al. 2015

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Non-Hodgkin lymphoma involving the esophagus is very rare. Only a few cases have been reported in the English literature to date, and it accounts for less than 1% of all cases of gastrointestinal lymphoma. As this malignancy manifests as a submucosal tumor, pathological diagnosis by using a simple endoscopic biopsy alone is difficult. Therefore, surgical biopsy, endoscopic mucosal resection, and endoscopic ultrasound-guided fine-needle aspiration have been used in most cases. Herein, we report a case of esophageal mucosa-associated lymphoid tissue lymphoma in a 49-year-old man, which involved the use of a stacked forceps biopsy to obtain adequate samples for pathological analysis; the use of the stacked forceps biopsy method is unlike those used in previous cases. The patient received cyclophosphamide, vincristine, and prednisolone chemotherapy; he achieved a complete response. In addition, we review the literature relevant to this case.

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Section: Introductionmentioning

confidence: 99%

Primary esophageal mucosa-associated lymphoid tissue lymphoma diagnosed by using stacked forceps biopsy

et al. 2015

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“…We found only six case reports of primary esophageal MALT lymphoma published in English. [5][6][7][8][9][10] The average age of these patients was 65.5 years (range, 49-83 years); there were fi ve men and one woman. Only one of these patients had symptoms, namely, dysphagia.…”

Section: Discussionmentioning

confidence: 99%

Mucosa-associated lymphoid tissue (MALT) lymphoma arising in the esophagus, stomach, and lung

Hayashi

Ueda

Tanaka

et al. 2011

Gen Thorac Cardiovasc Surg

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A 62-year-old woman was referred to our hospital for further investigation of slow-growing gastrointestinal submucosal tumors (SMTs) and multiple lung nodules. Esophageal SMTs had been identified 6 years earlier, following which lung tumors and gastric SMTs had subsequently developed. Despite repeated endoscopic biopsies, these SMTs could not be diagnosed definitively. Moreover, we were unable to detect any serological abnormalities or radiologic findings such as lymph node swelling. Thoracoscopic excision of a lung nodule led to the definitive diagnosis of mucosaassociated lymphoid tissue (MALT) lymphoma. Cytological findings of aspiration biopsy specimens from the esophagus and stomach were compatible with that of the lung nodule. To our knowledge, this is the first case report of esophageal MALT lymphoma with lung and gastric involvement. We discuss this extremely rare disease with reference to the relevant literature.

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“…[5] MALT lymphomas can arise in various anatomic locations where lymphocytes are usually absent due to acquisition of MALT, including the gut, lung, thyroid, salivary glands and liver [6] . Primary esophageal lymphoma is extremely rare [7] .…”

Section: Discussionmentioning

confidence: 99%

“…Esophageal involvement by lymphoma is usually secondary to local spread from the stomach or the mediastinum [8] . Very few cases of primary esophageal lymphomas were reported in literature [6][7][8][9][10][11] . There are many morphological variants with most of the common being large B cell type and Non-Hodgkin's lymphoma [9] .…”

Section: Discussionmentioning

confidence: 99%

Extremely rare case of primary esophageal mucous associated lymphoid tissue lymphoma

Malik

Baig²,

Ahmed³

et al. 2013

WJGE

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SJ is a 37-year-old male who presented with one year history of dysphagia, odynophagia and 15 pounds weight loss. He underwent endoscopic evaluation which showed mid esophageal ulcers. It was thought that the cause of the ulcer was the multivitamins and the patient was asked to stop them. Furthermore Esomeprazole therapy was also initiated. Patient's symptoms persisted but he did not seek any medical attention until about one year later. Meanwhile the patient reported additional 15 pounds of weight loss. We repeated upper endoscopy again which showed evidence of two chronic non bleeding irregular friable ulcerations seen in the mid esophagus, 31 cm from the incisors. Biopsies and frozen section were taken and sent for assessment to the Pathology lab. Immunoperoxidase studies on frozen sections showed the presence of IgM and for most plasma cells IgG. The microscopic and histologic findings were consistent with mucous associated lymphoid tissue lymphoma with plasmocytic differentiation. Computed tomographic scan done showed no evidence of spread to adjacent structures. The patient was referred to oncology and several cycles of radiation and Rituximab therapy were initiated which cured the disease. Subsequent endoscopies with blind biopsies were done which were negative for any neoplastic process. Key words: Lymphoma; Mucous associated lymphoid tissue; EsophagusCore tip: This is a case of a 37-year-old gentleman presenting with chronic esophageal ulcers. Endoscopic biopsy samples were taken. Immunohistochemistry and hematoxylin and eosin staining of the biopsy samples were consistent with mucous associated lymphoid tissue (MALT) lymphoma. There was no sign of disease process in the stomach, and radiological studies revealed no evidence of metastasis. In consideration of these findings a diagnosis of primary esophageal MALT lymphoma was made, which is an extremely rare occurrence. On the basis of our experiences we recommend keeping primary esophageal MALT lymphoma in the differential diagnosis of chronic esophageal ulcers that are resistant to conservative management.

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Mucosa-Associated Lymphoid Tissue Lymphoma of the Esophagus Coexistent with Bronchus-Associated Lymphoid Tissue Lymphoma of the Lung

Cited by 17 publications

References 13 publications

Primary esophageal mucosa-associated lymphoid tissue lymphoma diagnosed by using stacked forceps biopsy

Primary esophageal mucosa-associated lymphoid tissue lymphoma diagnosed by using stacked forceps biopsy

Mucosa-associated lymphoid tissue (MALT) lymphoma arising in the esophagus, stomach, and lung

Extremely rare case of primary esophageal mucous associated lymphoid tissue lymphoma

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